2013
DOI: 10.3945/ajcn.112.055905
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Vitamin D intake and lung cancer risk in the Women’s Health Initiative

Abstract: Background: Prior research suggests that vitamin D protects against lung cancer only among certain subgroups. Objectives: We investigated whether vitamin D intake was associated with lung cancer and explored whether vitamin A intake modified the association. Baseline total intake included both dietary intake (from food-frequency questionnaires) and supplement intake (from bottle labels). HRs were estimated by Cox proportional hazard models. Results: No significant association was observed overall. Among never … Show more

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Cited by 45 publications
(49 citation statements)
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References 48 publications
(46 reference statements)
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“…Our findings on high versus deficient levels of serum 25(OH)D are in the same direction as a prospective cohort study in the WHI reporting an inverse association of estimated dietary vitamin D exposure with lung cancer risk in never smokers [40]. The majority of lung cancer cases in these two studies were the same group of women.…”
Section: Discussionsupporting
confidence: 84%
See 1 more Smart Citation
“…Our findings on high versus deficient levels of serum 25(OH)D are in the same direction as a prospective cohort study in the WHI reporting an inverse association of estimated dietary vitamin D exposure with lung cancer risk in never smokers [40]. The majority of lung cancer cases in these two studies were the same group of women.…”
Section: Discussionsupporting
confidence: 84%
“…The majority of lung cancer cases in these two studies were the same group of women. The dietary vitamin D study showed that a higher total vitamin D intake (food+supplements) starting from 600 IU/day was significantly associated with a lower risk of lung cancer among never smokers (HR=0.55 [95% CI=0.31-0.96] for 600 to <800 [41 cases] vs. <100 IU/day; HR=0.37 [95% CI=0.18-0.77] for ≥800 [14 cases] vs. <100 IU/day) [40]. Significant inverse associations were also observed for both NSCLC and adenocarcinoma.…”
Section: Discussionmentioning
confidence: 99%
“…After an initial screening of retrieved abstracts, 14 papers were preliminarily considered for inclusion in the meta-analysis [11][12][13][14][15][16][17][18][19][26][27][28][29][30]. After applying inclusion criteria, two papers were further excluded [29,30], and 12 studies were finally included into the meta-analysis [11][12][13][14][15][16][17][18][19][26][27][28]. Among those 12 studies, 9 studies were prospective cohort studies [11, 13-15, 17-19, 26, 28], and 3 were nested case-control studies [12,16,27].…”
Section: Study Selection and Featuresmentioning
confidence: 99%
“…There is accumulating evidence suggesting that the low level of vitamin D is one of important risk factors for cancer and cancer-related mortality [231]. High 25(OH)D levels are related to reduction in mortality in patients suffering from colon, lung, and breast cancer [232,233]. The underlying pathophysiology is not completely understood, but it is suggested that antiproliferative and apoptotic effects of vitamin D on cancer cells, inhibition of metastatic distribution and tumor invasion, and promotion of sensitivity to radiation and chemotherapy influence on decreased mortality in cancers [233].…”
Section: Vitamin D Cancer and Menopausementioning
confidence: 99%