Vitamin D insufficiency is associated with higher carotid intima-media thickness in psoriatic patients

Abstract

Vitamin D insufficiency is associated with higher carotid intima-media thickness in psoriatic patientsBackground: Psoriasis has been associated with vitamin D insufficiency and cardiovascular risk factors. Reports show that serum 25-hydroxyvitamin D (25-OHD) levels are inversely associated with chronic inflammatory systemic diseases, cardiovascular risk factors and cardiovascular outcomes. Objective: To analyze the association between 25-hydroxyvitamin D serum levels and subclinical carotid atherosclerosis (maximal intima-media thickness (MIMT)) in psoriasis patients and controls. MIMT was compared and associated factors were analyzed. Patients and Method: This was a case-control study with 44 psoriatic patients without arthritis from a Dermatology outpatient clinic in Granada (Spain) and 44 controls. Confounding factors related to 25-OHD serum levels and cardiovascular risk factors were also analyzed. Results: 25-OHD levels were significantly lower in the psoriatic than in the control group (29.20 vs. 38.00 ng/mL p<0.0001) and a significant negative correlation was found between serum 25-OHD levels and the MIMT (r s = -0.678, p<0.0001) in psoriatic patients. No correlation was found in healthy controls. This association remained after adjusting for confounders. Serum 25-OHD levels were significantly lower (p = 0.003) in psoriatic patients with carotid atheromatous plaque (22.38 ± 10.23 ng/mL) than in those without (31.74 ± 8.62 ng/mL). Patients with a longer history of psoriasis presented significantly higher MIMT than controls (638.70 ± 76.21 vs 594.67 ± 80.20 m; p = 0.026 for ≥6 yrs with psoriasis). Conclusions: In psoriasis patients, lower serum 25-OHD levels were associated with higher MIMT after adjusting for selected confounding factors. The MIMT risk increases with a longer history of psoriasis, regardless of the patient's age.

Association Between Psoriasis and Subclinical Atherosclerosis

“…After full manuscripts assessed for eligibility, 26 articles appeared to satisfy the inclusion criteria. Six articles were excluded for the following reasons: one study 35 did not provide SD of the outcome; 2 studies 36 , 37 did not provide average intima-media thickness values; and participants’ selection did not match with age or sex in 2 studies. 38 , 39 One study 40 was further excluded because the reported FMD value was particularly high in both psoriatic patients and controls than other studies.…”

Vitamin D and progression of carotid intima‐media thickness in HIV‐positive Canadians

“…Null CIMT extent findings have been found in Old Order Amish Americans , individuals living at extremes of the socioeconomic spectrum in Scotland , people with diabetes , individuals with SLE , and a Danish cohort of people with HIV infection . Positive vitamin D−CIMT associations have been reported in the contexts of diabetes , psoriasis , postmenopausal woman , secondary CVD prevention , and HIV infection .…”

Increased expression of microRNA-155 in peripheral blood mononuclear cells from psoriasis patients is related to disease activity

“…Vitamin D‐VDR signalling in macrophages was proposed to limit the inflammatory response by targeting the miRNA‐155‐SOCS1 pathway, and by enhancing a negative feedback mechanism that atenuates TLR‐signalling. Vitamin D deficiency was reported in Ps patients …”