Vitamin D Insufficiency in Arabs and South Asians Positively Associates with Polymorphisms in GC and CYP2R1 Genes

Elkum, Naser; Alkayal, Fadi; Noronha, Fiona; Ali, Maisa M.; Melhem, Motasem; Alarouj, Monira; Bennakhi, Abdullah; Behbehani, Kazem; Alsmadi, Osama; Abubaker, Jehad

doi:10.1371/journal.pone.0113102

Cited by 72 publications

(62 citation statements)

References 31 publications

(46 reference statements)

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“…In addition, data collection, particularly for cytokine concentrations, began after approximately eight weeks of fall conditioning (August-September) which may have altered the true picture of how vitamin D status influences such concentrations during training and competition, however, they are a reality for the in-season college athletes. Finally, vitamin D binding protein (VDBP) and gene polymorphisms were not addressed in this study which may have influenced 25(OH)D concentrations [58,59]. …”

Section: Discussionmentioning

confidence: 99%

Vitamin D and Weight Cycling: Impact on Injury, Illness, and Inflammation in Collegiate Wrestlers

et al. 2016

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This study explored the link between vitamin D status and frequency of skin infections, inflammation, and injury in college wrestlers during an academic year. Methods: Serum 25-hydroxyvitamin D (25(OH)D) (n = 19), plasma cytokine (TNF-α, IL-6, IL-10) (n = 18) concentrations, and body weight/composition were measured and injury/illness/skin infection data were collected in fall, winter, and spring. Results: In the fall, 74% of wrestlers had vitamin D concentrations <32 ng/mL which increased to 94% in winter and spring. Wrestlers lost an average of 3.4 ± 3.9 kg (p < 0.001) during the season with corresponding decreases in fat mass and increases in lean mass (p < 0.01). An inverse association between 25(OH)D concentrations and total body mass and body fat percentage was observed at all-time points (p < 0.01). Concentrations of cytokines were highly variable among individuals and did not change across time (p > 0.05). Correlations between vitamin D status, cytokines, or frequency of illness, injury, or skin infections were not observed. Conclusions: A high prevalence of vitamin D insufficiency (<32 ng/mL) and deficiency (<20 ng/mL) was observed in wrestlers and was associated with higher adiposity. It remains unclear if higher vitamin D status would reduce injury, illness, and skin infection risk.

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Section: Discussionmentioning

confidence: 99%

Vitamin D and Weight Cycling: Impact on Injury, Illness, and Inflammation in Collegiate Wrestlers

et al. 2016

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“…With its incidence as high as 47%–68.97%, it is the main cause of tooth loss in adults [1–3]. It not only affects oral health, function, and aesthetics, but also has strong association with endocrine disturbance (e.g., diabetes mellitus, obesity, and osteoporosis) and cardiovascular disease [4–8]. Aggressive periodontitis, as an important branch of periodontitis, is characterized by early onset, severe periodontal destruction and familial aggregation.…”

Section: Introductionmentioning

confidence: 99%

“…Powe et al found racial variation and GC SNPs (rs4588 and rs7041) explained nearly 80% of DBP concentration difference in black and white Americans [19]. These three sites were reported to be associated with bone mineral density, obesity, and 25-hydroxyvitamin D concentration, which were important factors for periodontitis [4–8]. Xiong et al genotyped 1873 subjects from 405 white nuclear families across 20 genes and found GC rs17467825 was associated with spine bone mineral density [20].…”

Section: Introductionmentioning

confidence: 99%

“…Xiong et al genotyped 1873 subjects from 405 white nuclear families across 20 genes and found GC rs17467825 was associated with spine bone mineral density [20]. Individuals with rs17467825 GG were confirmed to have the lowest 25-hydroxyvitamin D concentration in Arab Asians [4]. Suaini et al found that rs17467825 minor allele was associated with increased odds of vitamin D insufficiency [21].…”

Section: Introductionmentioning

confidence: 99%

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GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis

Song

Wang

Tian

et al. 2016

International Journal of Endocrinology

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Objective. To explore whether GC (group-specific component) rs17467825, rs4588, and rs7041 polymorphisms are associated with generalized aggressive periodontitis. Methods. This case-control study recruited 372 patients with generalized aggressive periodontitis (group AgP) and 133 periodontal healthy subjects (group HP). GC rs17467825, rs4588, and rs7041 genotypes and plasmatic vitamin D-binding protein (DBP) were measured. Analysis of single SNP and multiple SNPs was performed and relevance between plasmatic DBP and haplotypes was analyzed. Results. GC rs17467825 GG genotype was statistically associated with lower risk for generalized aggressive periodontitis under the recessive model (OR = 0.52, 95% CI: 0.30–0.92, p = 0.028). GC rs17467825 and rs4588 had strong linkage disequilibrium with r 2 ≥ 0.8 and D′ ≥ 0.8. Haplotype (GC rs17467825, rs4588) GC was associated with the less risk for generalized aggressive periodontitis (OR = 0.29, 95% CI: 0.09–0.96, p = 0.043). In group AgP, individuals with combined genotype (GC rs17467825, rs4588) AG+CA had significantly lower plasmatic DBP level than those with the other two combined genotypes (AG+CA versus AA+CC p = 0.007; AG+CA versus GG+AA p = 0.026). Conclusions. GC rs17467825 genotype GG and haplotype (GC rs17467825, rs4588) GC are associated with generalized aggressive periodontitis. The association may be acquired through regulating DBP levels. The functions of GC gene and DBP in inflammatory disease need to be further studied.

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“…The possible role of alleles associated with vitamin D level in Arabs has also been reported (Elkum et al, 2014). Obesity presents another risk factor since the body fat sequesters vitamin D. Qatar has a very high prevalence of overweight and obesity, estimated to be between two-thirds and three-quarters of all adults (Ng et al, 2010).…”

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confidence: 99%

Validity of self‐reported vitamin D deficiency among midlife Arab women living in Qatar

Gerber

Giambrone

Al-Ali

et al. 2015

American J Hum Biol

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Objectives This study evaluates the level of agreement between self-reported vitamin D deficiency and serum vitamin D measured within the previous calendar year. Methods In a study in which serum 25(OH)D levels were retrieved from electronic health records, 523 women were asked whether they considered themselves to have vitamin D deficiency. Serum vitamin D levels were categorized as vitamin D deficiency if serum 25(OH)D was less than 20 ng/ml and as insufficiency if less than 30 ng/ml. The kappa statistic was computed to assess the level of agreement between serum 25(OH)D level and self-report responses. Results Agreement between self-reported and measured 25(OH)D levels was poor. The kappa statistic was −0.041 when using a cutpoint of <20 ng/ml and −0.008 using the cutpoint of < 30 ng/ml. Among women with levels ≥ 20 ng/ml, 82.4% believed that they were vitamin D deficient, while 13.3% who were below <20 ng/ml did not self-report deficiency. Among women who did not report vitamin D deficiency, 46.3% (37/80) had levels <20 ng/ml while 82.5% (66/80) had levels < 30 ng/ml. Conclusions These findings suggest that, although the prevalence of 25(OH)D < 20 ng/ml and < 30 ng/ml was quite high (53.2% and 84.7%, respectively), there was little agreement between measured levels and self-report of vitamin D deficiency. This may be due to belief in this region that low levels of serum vitamin D is widespread. Better communication is needed between healthcare providers and patients regarding transmission of laboratory results.

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Vitamin D Insufficiency in Arabs and South Asians Positively Associates with Polymorphisms in GC and CYP2R1 Genes

Cited by 72 publications

References 31 publications

Vitamin D and Weight Cycling: Impact on Injury, Illness, and Inflammation in Collegiate Wrestlers

Vitamin D and Weight Cycling: Impact on Injury, Illness, and Inflammation in Collegiate Wrestlers

GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis

Validity of self‐reported vitamin D deficiency among midlife Arab women living in Qatar

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