Vitamin D insufficiency and hyperparathyroidism in Perth blood donors

Vasikaran, Samuel; Sturdy, Gary; Musk, Alexander A.; Flicker, Leon

doi:10.5694/j.1326-5377.2000.tb124028.x

Cited by 13 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is a high prevalence of vit D insufficiency in many Western countries 30 , 31 , 32 and a substantial body of epidemiological evidence indicates a negative correlation between levels of vit D and the incidence of a number of inflammatory diseases world‐wide. The amount of vit D3 in the vit D + diet was sufficient to produce levels of 25OHD in serum (160±5 nmol l –1 ), which is at the high end of the reference range for normal humans 25 .…”

Section: Discussionmentioning

confidence: 99%

Efficacy and mechanisms of action of vitamin D in experimental polyarthritis

et al. 2011

View full text Add to dashboard Cite

Vitamin D (vit D) status has been linked to the occurrence and severity of auto-immune and inflammatory diseases. This study evaluates the effects of vit D status on adoptive transfer of adjuvant-induced arthritis (ATA). Rats maintained on diets replete or deficient in vit D3 received arthritogenic thoracic duct cells and were monitored for severity of arthritis. CD45 + cells obtained by collagenase digestion of hind-paw synovium-rich tissues (SRTs) were analysed to observe the effects of dietary vit D3 on the inflammatory process. Arthritis was more severe in vitamin D-deficient (vit-D À ) rats compared with vitamin D-replete (vit-D + ) rats. Resolution was delayed in vit-D À rats compared with vit-D + rats, or rats fed standard chow. During the acute phase of ATA, numbers of CD45 + cells were significantly increased in the SRTs of vit-D À rats compared with vit-D + rats. This increase involved T-cells, polymorphonuclear leukocytes, macrophages, dendritic cells (DCs) and MHC II hi cells that resemble activated monocytes. A major difference between the dietary groups was that most DCs at the peak of inflammation in vit-D À rats were CD4 -, whereas in convalescent vit-D + rats most expressed CD4. Multiple categories of genes expressed by DCs differed between deficient and replete rats, with deficiency being associated with relative upregulation of certain pro-inflammatory genes and replete status being associated with upregulation of genes associated with resolution of inflammation. The findings indicate that ATA is more severe and prolonged in vit-D deficiency, that vit-D deficiency promotes accumulation of CD4 À DCs in synovium during ATA and that a gene-expression profile is likely to contribute to the observed increased severity and duration of arthritis. The role of vitamin D (vit D) in calcium homeostasis and maintenance of skeletal health has long been recognised. 1 The vit D receptor has been found on more than 35 cell types 2 and more recently the immuno-regulatory effects of vit D have been appreciated. The latter properties have been observed in experimentally induced animal models of autoimmune diseases, including experimental autoimmune encephalomyelitis, 3 collagen-induced arthritis, 4 autoimmune type 1 diabetes, 5 T-cell-mediated colitis 6 and murine lupus. 7 Epidemiological studies have linked vit D insufficiency with frequency of a number of autoimmune diseases, including multiple sclerosis, 8 rheumatoid arthritis (RA), 9 type 1 diabetes, 10 Bechet's syndrome 11 and inflammatory bowel disease. 12 Epidemiological evidence has also associated higher dietary intake of vit D with protection from autoimmune diseases. 13,14 The present study was undertaken to explore the effects of vit D status in a well-characterised model of immune-mediated arthritis. Adjuvant-induced arthritis (AIA) is a T-cell-mediated disease 15 that has similarities to rheumatoid arthritis in distribution (predominantly peripheral and symmetrical) and in histopathology. 16 We have shown that ATA, induced using thoracic duct (TD)...

show abstract

Section: Discussionmentioning

confidence: 99%

Efficacy and mechanisms of action of vitamin D in experimental polyarthritis

et al. 2011

View full text Add to dashboard Cite

show abstract

“…12 Studies of healthy rural and urban Australians across a wide age range have found a low prevalence of conven-tionally defined vitamin D deficiency. [13][14][15] Australia has a generally sunny climate, and fortification of the food supply with vitamin D has not been considered necessary. A high prevalence of vitamin D deficiency (defined as a serum 25hydroxyvitamin D (25D) o25 nM) 2,6 has previously been demonstrated in Australian hostel and nursing home residents, and associations between the level of serum 25D and falling in these residents has been demonstrated retrospectively 6 and prospectively.…”

mentioning

confidence: 99%

“…Studies of healthy rural and urban Australians across a wide age range have found a low prevalence of conventionally defined vitamin D deficiency 13–15 . Australia has a generally sunny climate, and fortification of the food supply with vitamin D has not been considered necessary.…”

mentioning

confidence: 99%

Should Older People in Residential Care Receive Vitamin D to Prevent Falls? Results of a Randomized Trial

Flicker

MacInnis

Stein

et al. 2005

J American Geriatrics Society

Self Cite

263

245

View full text Add to dashboard Cite

show abstract

“…Similar findings were reported from a study in south‐east Queensland of men and women in the age range 18–87 years; 32 at the end of winter, the prevalence of vitamin D deficiency was 42%. A study of nearly 200 blood donors of both sexes in winter and spring in Perth reported that 34% had 25(OH)D levels < 50 nmol/L 227 . The largest study of nearly 11 300 Australians from Darwin to Hobart showed that 31% had 25(OH)D levels < 50 nmol/L 23 .…”

Section: The Role Of Vitamin Dmentioning

confidence: 99%