Building healthy bones throughout life: an evidence‐informed strategy to prevent osteoporosis in Australia

Ebeling, Peter R.; Daly, Robin M.; Kerr, Deborah A.; Kimlin, Michael G.

doi:10.5694/mjao12.11363

Cited by 35 publications

(49 citation statements)

References 610 publications

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“…reducing falls) should always be offered. Weight‐bearing exercises and physiotherapy are an important part of primary and secondary prevention, and enhancing muscle strength and function may reduce falls . Correcting cholecalciferol deficiency may also be important to maintain and improve bone and muscle health.…”

Section: Bone Health In Patients With Chronic Kidney Disease–mineral mentioning

confidence: 99%

Bone health in chronic kidney disease‐mineral and bone disorder: a clinical case seminar and update

Aleksova

Jung

et al. 2018

Internal Medicine Journal

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The metabolic abnormalities affecting bone in the setting of chronic kidney disease (CKD) are complex with overlapping and interacting aetiologies and have challenging diagnostic and management strategies. Disturbances in calcium, phosphate, fibroblast growth factor 23, parathyroid hormone concentrations and vitamin D deficiency are commonly encountered and contribute to the clinical syndromes of bone disorders in CKD, including hyperparathyroidism, osteomalacia, osteoporosis and adynamic bone disease. Mineral and bone abnormalities may also persist or arise de novo post‐renal transplantation. The Kidney Disease Improving Global Outcomes organisation describes these mineral metabolism derangements and skeletal abnormalities as ‘CKD Mineral and Bone Disorder’. Patients with this disorder have an increased risk of fracture, cardiovascular events and overall increased mortality. In light of the recently updated 2017 guidelines from the Kidney Disease Improving Global Outcomes, we present a clinical case‐based discussion to highlight the complexities of investigating and managing the bone health of patients with CKD with a focus on these updates.

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Section: Bone Health In Patients With Chronic Kidney Disease–mineral mentioning

confidence: 99%

Bone health in chronic kidney disease‐mineral and bone disorder: a clinical case seminar and update

Aleksova

Jung

et al. 2018

Internal Medicine Journal

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“…Thereafter, bone mass is continually on the decline as we age and may lead to osteopenia and osteoporosis - one of the most important musculoskeletal disorders and among the leading causes of chronic pain, frailty and loss of quality of life worldwide45. While there are genetic predispositions and disease related conditions that promote the development of osteoporosis, an elevated peak bone mass at the height of skeletal maturity seems to be predictive of a low risk for osteoporotic fractures at old age16789.…”

mentioning

confidence: 99%

Sprint Interval Training Induces A Sexual Dimorphism but does not Improve Peak Bone Mass in Young and Healthy Mice

Koenen

Knepper

Klodt

et al. 2017

Sci Rep

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Elevated peak bone mass in early adulthood reduces the risk for osteoporotic fractures at old age. As sports participation has been correlated with elevated peak bone masses, we aimed to establish a training program that would efficiently stimulate bone accrual in healthy young mice. We combined voluntary treadmill running with sprint interval training modalities that were tailored to the individual performance limits and were of either high or intermediate intensity. Adolescent male and female STR/ort mice underwent 8 weeks of training before the hind legs were analyzed for cortical and trabecular bone parameters and biomechanical strength. Sprint interval training led to increased running speeds, confirming an efficient training. However, males and females responded differently. The males improved their running speeds in response to intermediate intensities only and accrued cortical bone at the expense of mechanical strength. High training intensities induced a significant loss of trabecular bone. The female bones showed neither adverse nor beneficial effects in response to either training intensities. Speculations about the failure to improve geometric alongside mechanical bone properties include the possibility that our training lacked sufficient axial loading, that high cardio-vascular strains adversely affect bone growth and that there are physiological limits to bone accrual.

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“…This paper focuses on the adverse bone and muscle effects of longer‐term oral corticosteroid use. Long‐term oral corticosteroid use is the most common cause of secondary osteoporosis, which is a major cause of pain, disability, impaired quality of life and premature death in older men and women . A meta‐analysis estimated the risk of hip fracture was doubled, and vertebral fracture was almost tripled in patients taking an average daily dose of 7.8 mg prednisolone and a cumulative dose of 13.9 g prednisolone .…”

Section: Introductionmentioning

confidence: 99%

“…Encourage patients to eat a balanced healthy diet, rich in calcium and vitamin D. To achieve the recommended dietary calcium intake of 1000 to 1300 mg per day for adult men and women, three to four servings of calcium‐containing foods are required each day. A calcium‐fortified food may also be required for some people . Initiate a calcium supplement if dietary intake is inadequate and initiate a vitamin D supplement, especially in residents of aged care facilities .…”

Section: Introductionmentioning

confidence: 99%

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Minimising fracture risk in older people taking long‐term oral corticosteroids

Westaway

Frank

Husband³

et al. 2017

Pharmacy Practice and Res

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Corticosteroids have potent anti‐inflammatory and immunosuppressant properties but are associated with a number of serious adverse events. When taken orally for longer than 3 months, particularly at prednisolone‐equivalent doses greater than 5 mg per day, corticosteroids are associated with a high incidence of bone loss, muscle atrophy and weakness. Fracture risk is increased as a result of corticosteroid‐induced bone loss and muscle weakness. Corticosteroid‐related fractures are a serious complication of long‐term oral corticosteroid therapy. The aim of this article is to provide practical information to help clinicians to minimise fracture risk in older people taking long‐term oral corticosteroids. When therapy is instigated for longer than 1 month, identify at‐risk patients promptly and consider a calcium and vitamin D supplement and fracture prevention therapy. Patients at risk include those receiving prednisolone‐equivalent doses of more than 5 mg per day for longer than 3 months and patients receiving frequent short courses of high‐dose corticosteroids.

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Building healthy bones throughout life: an evidence‐informed strategy to prevent osteoporosis in Australia

Cited by 35 publications

References 610 publications

Bone health in chronic kidney disease‐mineral and bone disorder: a clinical case seminar and update

Bone health in chronic kidney disease‐mineral and bone disorder: a clinical case seminar and update

Sprint Interval Training Induces A Sexual Dimorphism but does not Improve Peak Bone Mass in Young and Healthy Mice

Minimising fracture risk in older people taking long‐term oral corticosteroids

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