Vitamin D Insufficiency and Asthma Severity in Adults From Costa Rica

Montero-Arias, Felicia; Mejía, Giovanni Sedó; Ramos-Esquivel, Allan

doi:10.4168/aair.2013.5.5.283

Cited by 49 publications

(46 citation statements)

References 29 publications

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“…A similar finding had been stated by many studies with the same result on elderly asthmatic patients, where (79%) had lower than normal serum vitamin D at baseline [23]. These results confirm that vitamin D deficiency and insufficiency are extremely common in patients with asthma [26], and mostly pronounced in patients with severe and/or uncontrolled asthma [18]. Kamran et al found a high prevalence of vitamin D deficiency and insufficiency (88.10%) in adult patients with moderate to severe persistent asthma [27].…”

Section: Discussionsupporting

confidence: 79%

Study the Potential Antioxidant Effect of Vitamin D3 Supplementation on the Level of Extracellular Superoxide Dismutase in Asthmatic Patients

Abbas

Abdulridha

Shafek

2017

Asian J Pharm Clin Res

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Objective: This study was designed to evaluate the potential antioxidant effect of vitamin D 3 supplementation in chronic asthma patients.Methods: A total of 44 candidate patients were diagnosed with asthma allocated as Group 1 includes 20 patients assigned to receive conventional therapy for asthma and Group 2 includes 24 patients assigned to receive conventional therapy for asthma plus 2000 IU vitamin D 3 tablet for 3-month period. Furthermore, 30 apparently healthy subjects were included in the study as a control group. Pulmonary function test, serum 25-hydroxy vitamin D levels, serum extracellular superoxide dismutase (SOD3) levels were measured before and after 3 months therapy. Results:The mean forced expiratory volume in 1 second (FEV1) both the measured and the percentage of predicted value showed a highly significant increase after 3 months treatment compared to pre-treatment value in both study groups (p<0.01). When compared to pre-treatment value, there was no significant increase in forced expiratory volume in one second to forced vital capacity ratio (FEV1/FVC) in Group 1 (p>0.05), nevertheless, Group 2 showed highly significant increase after 3 months (p<0.01). Approximately, 90-96% of adult asthmatic patients revealed vitamin D deficiency (<20 ng/ml). Post-treatment with adjuvant vitamin D 3 therapy, 25% of patients obtained acceptable level of vitamin D sufficiency (≥30 ng/ml). After 3 months of the treatment, Group 1 patients showed a significant decrease in mean SOD3 level compared to pre-treatment level (p<0.05), while Group 2 patients showed a significant increase in mean SOD3 level compared to pre-treatment level (p<0.05). Conclusion:Most of the asthmatic patients revealed vitamin D deficiency and supplementation with vitamin D3 reduce oxidative stress burden in those patients.

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Section: Discussionsupporting

confidence: 79%

Study the Potential Antioxidant Effect of Vitamin D3 Supplementation on the Level of Extracellular Superoxide Dismutase in Asthmatic Patients

Abbas

Abdulridha

Shafek

2017

Asian J Pharm Clin Res

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“…Conforme al sexo, la mediana de la concentración de VD no fue diferente (p = 0.713): en los hombres 16 ng/mL (RIC, 14-22) y en las mujeres 18 ng/mL (RIC, [13][14][15][16][17][18][19][20][21][22][23]. Respecto a la actividad física, la mediana fue mayor en quienes realizaban ejercicio en comparación con quienes no lo hacían (p = 0.004): 18 ng/mL La concentración de VD mostró correlación negativa con la edad (p =0.047) y positiva con la actividad física (p = 0.004), como se describe en el Cuadro 3.…”

Section: Resultsunclassified

“…En Costa Rica, 14 la deficiencia e insuficiencia de VD en su conjunto fue de 90 %, similar a la observada en nuestra investigación. En niños, un análisis realizado en varias ciudades de Colombia mostró una frecuencia de alteraciones en la concentración de VD, insuficiencia o deficiencia, en 8.9 a 29.8 % de los casos.…”

Section: Discussionunclassified

“…Ahora bien, diversos estudios alrededor del mundo han documentado una relación entre los niveles bajos de VD con una peor función pulmonar en sujetos con asma. 4,7,14,16,19,26,27,28 Si bien exploramos esta asociación de manera superficial mediante una prueba de correlación, sin encontrar asociación estadísti-camente significativa, reconocemos que se requieren mayores estudios y otro tipo de análisis.…”

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Prevalencia de insuficiencia y deficiencia de vitamina D en adultos mexicanos con asma alérgica

Bedolla-Barajas

López-Hernández

García-Padilla

et al. 2017

RAM

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Background: Hypovitaminosis D has been associated with various chronic diseases such as infections, autoimmune diseases, chronic obstructive pulmonary disease, cancer and asthma Objective: The objective at hand is to determine the prevalence of vitamin D (VD) insufficiency and deficiency in adults with allergic asthma. Methods: Through a cross-sectional study, we analyzed corresponding data amongst 135 patients. VD concentration was categorized as sufficient (≥ 30 ng/mL), insufficient (21-29 ng/mL), and deficient (≤ 20 ng/mL). The level of VD deficiency was measured through chemo-luminescence. We estimated the prevalence of VD alterations and their respective confidence intervals at 95 % (CI 95 %). Results: Within the analyzed population, there were 99/135 women (73.3 %); the mean age was 34.5 ± 10.3 years. The mean concentration of VD was 17.9 ± 6.9 ng/mL and the median was 17 ng/mL. The prevalence of VD insufficiency and deficiency was 25.2 % (CI 95 %, 18.6-33.2 %) and 71.1 % (CI 95 %, 62.9-78.1 %), respectively; VD concentrations ≤ 10 ng/mL had 13.3 % (CI 95 %, 8.5-20.2 %) and ≥ 30 ng/mL at 3.7 % (CI 95 %: 1.4-8.6 %). When we contrasted the men to the women, the median concentration of VD did not differ significantly (16 ng/mL vs. 18 ng/mL, p = 0.71). Conclusions: In this study, patients with allergic asthma had distinctively reduced VD concentration levels; future research will determine if and how VD affects the severity of asthma.

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“…Furthermore, among pregnant women, vitamin D intake was found to be independently positively associated with the prevalence of asthma throughout pregnancy [24]. Among studies assessing vitamin D by serum 25(OH)D levels, some have found inverse associations between vitamin D status and allergy [1], infections [4], asthma [6,25], while others have not [22,26]. Among intervention trials investigating the effects of vitamin D supplementation on respiratory conditions, inconsistent results have been found [27][28][29][30].…”

Section: Variable Sun Exposure-vitamin D Index Score <mentioning

confidence: 98%

Relation of Vitamin D Intake and Sun Exposure to Respiratory Conditions in Hispanics

Ma¹,

Irizarry-Ramírez²,

Segarra³

et al. 2016

J Food Nutri Diete

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Vitamin D Insufficiency and Asthma Severity in Adults From Costa Rica

Cited by 49 publications

References 29 publications

Study the Potential Antioxidant Effect of Vitamin D3 Supplementation on the Level of Extracellular Superoxide Dismutase in Asthmatic Patients

Study the Potential Antioxidant Effect of Vitamin D3 Supplementation on the Level of Extracellular Superoxide Dismutase in Asthmatic Patients

Prevalencia de insuficiencia y deficiencia de vitamina D en adultos mexicanos con asma alérgica

Relation of Vitamin D Intake and Sun Exposure to Respiratory Conditions in Hispanics

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