Vitamin D–induced up–regulation of tumour necrosis factor alpha (TNF–α) in prostate cancer cells

Golovko, Olga; Nazarova, Nadya; Tuohimaa, Pentti

doi:10.1016/j.lfs.2004.10.072

Cited by 17 publications

(14 citation statements)

References 53 publications

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“…This suggest that TNF-α acts independently of 1α,25(OH) 2 D 3 in activation of the JNK/SAPK signaling pathway. These results are consistent with the findings of Golovko et al (2005), who reported that under physiological conditions, 1α,25(OH) 2 D 3 does not affect the production of TNF-α, but that TNF-α mRNA expression was up-regulated by 1α,25(OH) 2 D 3 as well as its analogue CB1093 in LNCaP and PC3 prostate cancer cells. Chopra et al (2004) studied the role of TNF-α in regulation of growth and apoptosis in three different prostate cell lines: normal prostate epithelial cells, LNCaP cells and PC3 cells and could demonstrate that normal prostate epithelial cells and PC3 cells were resistant to growth arrest and apoptosis induced by TNF-α and LNCaP cells were highly sensitive to the growth factor.…”

Section: Effects Of 1α25(oh) 2 D 3 On Tnf-α Production In Lncap Cellsupporting

confidence: 92%

“…Chopra et al (2004) studied the role of TNF-α in regulation of growth and apoptosis in three different prostate cell lines: normal prostate epithelial cells, LNCaP cells and PC3 cells and could demonstrate that normal prostate epithelial cells and PC3 cells were resistant to growth arrest and apoptosis induced by TNF-α and LNCaP cells were highly sensitive to the growth factor. Thus, from the results in the present study as well as previous studies (Golovko et al, 2005;Chopra et al, 2004,) we conclude that 1α,25(OH) 2 D 3 and TNF-α acts through independent pathways ending up in an up-regulation of AP1-dependent gene expression. PKA/CREB-dependent gene expression was determined in LNCaP prostate cancer cells by a CREB reporter assay (SA Biosciences) by measuring Firefly luciferase activity relative to the Renilla luciferase activity after treatment with 1 ,25(OH) 2 D 3 (10 -7 M) with or without GDP-β-S (100 µM), using ethanol as control.…”

Section: Effects Of 1α25(oh) 2 D 3 On Tnf-α Production In Lncap Cellsupporting

confidence: 87%

“…Other studies indicate that activation of JNK also seems to regulate and can be regulated by NF-κB (Nachmias et al, 2004). A similar result to the sulforaphane inhibition of the TNFinduced NF-κB has been reported for breast cancer cells treated with vitamin D. Thus, Michigan cancer foundation 7 (MCF-7) breast cancer cells, were found to become sensitized to apoptosis induced by TNF-when treated with 1 ,25(OH) 2 D 3 (Golovko et al, 2005).…”

Section: Introductionsupporting

confidence: 70%

See 2 more Smart Citations

Membrane Initiated Effects of 1α,25-Dihydroxyvitamin D3 in Prostate Cancer Cells: Effects on AP1 and CREB Mediated Transcription

Larsson¹,

Jonas²,

Bergsten³

et al. 2012

Current Frontiers and Perspectives in Cell Biology

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Section: Effects Of 1α25(oh) 2 D 3 On Tnf-α Production In Lncap Cellsupporting

confidence: 92%

Section: Effects Of 1α25(oh) 2 D 3 On Tnf-α Production In Lncap Cellsupporting

confidence: 87%

Section: Introductionsupporting

confidence: 70%

See 1 more Smart Citation

Membrane Initiated Effects of 1α,25-Dihydroxyvitamin D3 in Prostate Cancer Cells: Effects on AP1 and CREB Mediated Transcription

Larsson¹,

Jonas²,

Bergsten³

et al. 2012

Current Frontiers and Perspectives in Cell Biology

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“…Pro-inflammatory cytokines such as IL-6 and TNFa, produced by monocytes/macrophages, were found to affect the expression of hepatic transporters and enzymes [46], and these inflammatory factors are known to be regulated by 1,25(OH) 2 D 3 in vitro [47,48]. However, similar results were not known in vivo.…”

Section: Discussionmentioning

confidence: 99%

1α,25‐dihydroxyvitamin D₃ triggered vitamin D receptor and farnesoid X receptor‐like effects in rat intestine and liver in vivo

Chow

Maeng

Liu

et al. 2009

Biopharm & Drug Disp

114

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1alpha,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), a natural ligand of the vitamin D receptor (VDR), was found to increase the rat ileal Asbt and bile acid absorption. The effects of VDR, whose expression is low in liver, on hepatic transporters and enzymes are unknown. Protein and mRNA levels of target genes in the small intestine, colon and liver after intraperitoneal dosing of 1,25(OH)(2)D(3) (0-2.56 nmol/kg/day for 4 days) to the rat were determined by Western blotting and qPCR, respectively. The 1,25(OH)(2)D(3) treatment increased total Cyp3a protein and Cyp3a1 mRNA expressions in the proximal small intestine, and the short heterodimer partner (SHP), the fibroblast growth factor 15 (FGF15), organic solute transporter (Ostalpha and Ostbeta) mRNA and Asbt protein expressions in the ileum. About 50% higher portal bile acid concentration (65.1+/-14.9 vs 41.9+/-7.8 microm, p<0.05) and elevated expressions of the hepatic farnesoid X receptor (FXR) and SHP mRNA resulted with 1,25(OH)(2)D(3) treatment. Increased Bsep and Ostalpha mRNA expressions in liver and a>50% reduction in the Cyp7a1 protein level (p<0.05) and cholesterol metabolism in rat liver microsomes (p=0.002), likely consequences of the bile acid-FXR-SHP cascade and activation of the signaling pathway for Cyp7a1 inhibition by FGF15, were found. Increased hepatic multidrug resistance-associated protein (Mrp3) and multidrug resistance protein 1a (Mdr1a) mRNA and P-gp protein were also observed. It was concluded that the changes in hepatic transporters and enzymes in the rat were indirect, secondary effects of the liver FXR-SHP cascade due to increased intestinal absorption of bile acids and elevated levels of FGF15, events that led to the activation of FXR.

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“…Other cell types that were analyzed are prostate cancer lines, where 1α,25(OH) 2 D 3 reduced basal TNFα mRNA expression (Golovko et al, 2005), or 1α,25(OH) 2 D 3 /IL-1β-stimulated synoviocytes, where TNFα mRNA was decreased (Feng et al, 2013). …”

Section: α25(oh)2d3 As Regulator Of Cytokine Gene Expression Protementioning

confidence: 99%

Vitamin D in inflammatory diseases

2014

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Changes in vitamin D serum levels have been associated with inflammatory diseases, such as inflammatory bowel disease (IBD), rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis (MS), atherosclerosis, or asthma. Genome- and transcriptome-wide studies indicate that vitamin D signaling modulates many inflammatory responses on several levels. This includes (i) the regulation of the expression of genes which generate pro-inflammatory mediators, such as cyclooxygenases or 5-lipoxygenase, (ii) the interference with transcription factors, such as NF-κB, which regulate the expression of inflammatory genes and (iii) the activation of signaling cascades, such as MAP kinases which mediate inflammatory responses. Vitamin D targets various tissues and cell types, a number of which belong to the immune system, such as monocytes/macrophages, dendritic cells (DCs) as well as B- and T cells, leading to individual responses of each cell type. One hallmark of these specific vitamin D effects is the cell-type specific regulation of genes involved in the regulation of inflammatory processes and the interplay between vitamin D signaling and other signaling cascades involved in inflammation. An important task in the near future will be the elucidation of the regulatory mechanisms that are involved in the regulation of inflammatory responses by vitamin D on the molecular level by the use of techniques such as chromatin immunoprecipitation (ChIP), ChIP-seq, and FAIRE-seq.

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Vitamin D–induced up–regulation of tumour necrosis factor alpha (TNF–α) in prostate cancer cells

Cited by 17 publications

References 53 publications

Membrane Initiated Effects of 1α,25-Dihydroxyvitamin D3 in Prostate Cancer Cells: Effects on AP1 and CREB Mediated Transcription

Membrane Initiated Effects of 1α,25-Dihydroxyvitamin D3 in Prostate Cancer Cells: Effects on AP1 and CREB Mediated Transcription

1α,25‐dihydroxyvitamin D₃ triggered vitamin D receptor and farnesoid X receptor‐like effects in rat intestine and liver in vivo

Vitamin D in inflammatory diseases

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Vitamin D–induced up–regulation of tumour necrosis factor alpha (TNF–α) in prostate cancer cells

Cited by 17 publications

References 53 publications

Membrane Initiated Effects of 1α,25-Dihydroxyvitamin D3 in Prostate Cancer Cells: Effects on AP1 and CREB Mediated Transcription

Membrane Initiated Effects of 1α,25-Dihydroxyvitamin D3 in Prostate Cancer Cells: Effects on AP1 and CREB Mediated Transcription

1α,25‐dihydroxyvitamin D3 triggered vitamin D receptor and farnesoid X receptor‐like effects in rat intestine and liver in vivo

Vitamin D in inflammatory diseases

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Product

Resources

About

1α,25‐dihydroxyvitamin D₃ triggered vitamin D receptor and farnesoid X receptor‐like effects in rat intestine and liver in vivo