Vitamin D Inadequacy Is Associated with Significant Coronary Artery Stenosis in a Community-Based Elderly Cohort: The Korean Longitudinal Study on Health and Aging

Lim, Soo; Shin, Hayley; Kim, Min Ju; Ahn, Hwa Young; Kang, Seon Mee; Yoon, Ji Won; Choi, Sung Hee; Kim, Ki Woong; Song, Jung Han; Choi, Sang Il; Chun, Eun Ju; Shin, Chan Soo; Park, Kyong Soo; Jang, Hak Chul

doi:10.1210/jc.2011-1580

Cited by 78 publications

(69 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The relationship between vitamin D inadequacy and significant coronary artery stenosis was also found by Lim et al [28]. The coronary artery calcium score and stenosis were evaluated using multidetector-row cardiac computed tomography.…”

Section: Discussionsupporting

confidence: 54%

Vitamin D level and extent of coronary stenotic lesions in patients with first acute myocardial infarction

2013

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 54%

Vitamin D level and extent of coronary stenotic lesions in patients with first acute myocardial infarction

2013

View full text Add to dashboard Cite

show abstract

“…Th e relation between (25(OH)D) and coronary artery stenosis has been demonstrated previously by CCTA in a particular data set: asymptomatic African American long-term cocaine users [5]. In the Korean longitudinal study on health and aging, a signifi cant relationship between (25(OH)D) status and coronary artery stenosis was found in a community-based elderly cohort [14]. As diff erent from these studies, our patient population was consisted of young adults and additionally the relation between 25(OH)D and the severity of coronary atherosclerosis and plaque morphology was also investigated.…”

Section: Discussionmentioning

confidence: 53%

Association between serum vitamin D levels and subclinical coronary atherosclerosis and plaque burden/composition in young adult population

Satılmış

Çelik²,

Bıyık

et al. 2015

Biomol Biomed

View full text Add to dashboard Cite

Evidence suggests that low 25-OH vitamin D 25(OH)D concentrations may increase the risk of several cardiovascular diseases such as hypertension, peripheral vascular disease, diabetes mellitus, obesity, myocardial infarction, heart failure and cardiovascular mortality. Recent studies suggested a possible relationship between vitamin D defi ciency and increased carotid intima-media wall thickness and vascular calcifi cation. We hypothesized that low 25(OH)D may be associated with coronary atherosclerosis and coronary plaque burden and composition, and investigated the relationship between serum vitamin D levels and coronary atherosclerosis, plaque burden or structure, in young adult patients by using dual-source 128x2 slice coronary computed tomography angiography (CCTA). We included 98 patients with coronary atherosclerosis and 110, age and gender matched, subjects with normal fi ndings on CCTA examinations. Patients with subclinical atherosclerosis had signifi cantly higher serum total cholesterol, triglycerides, hs-CRP, uric acid, HbA1c and creatinine levels and lower serum 25(OH)D levels in comparison with controls. Th ere was no signifi cant correlation between 25(OH)D and plaque morphology. Th ere was also a positive relationship between 25(OH)D and plaque burden of coronary atherosclerosis. In multivariate analysis, coronary atherosclerosis was associated high hs-CRP (adjusted OR: 2.832), uric acid (adjusted OR: 3.671) and low 25(OH)D (adjusted OR: 0.689). Low levels of 25(OH)D were associated with coronary atherosclerosis and plaque burden, but there was no signifi cant correlation between 25(OH)D and plaque morphology.

show abstract

“…Estos resultados contrastan con estudios que han mostrado que los valores bajos de VD se asocian a un estado inflamatorio sistémico, favorecen la resistencia a la insulina y activan el sistema renina-angiotensina-aldosterona, con la subsecuente elevación de la presión arterial y la hipertrofia del músculo cardiaco y de las células musculares lisas [28][29][30] . En concordancia con estos hallazgos, varios estudios observacionales han reportado una asociación entre la deficiencia de 25(OH)D y la presencia de EAC clínica 13,31-33 y subclínica [34][35][36][37][38] . En un estudio de casos y controles en el que se incluyeron tanto pacientes con enfermedad coronaria como pacientes con enfermedad vascular cerebral, la deficiencia de 25(OH)D, definida por concentraciones inferiores a 15 ng/ml, mostró una alta prevalencia en pacientes (68%) y en controles (54%), y se encontró asociada a la presencia de enfermedad cardiovascular (OR: 2.9 [1.67-5.12]; p < 0.001) 33 .…”

Section: Discussionunclassified

Deficiencia de vitamina D y su asociación con enfermedad arterial coronaria en población mexicana: estudio Genético de la Enfermedad Aterosclerosa

López-Bautista¹,

Posadas‐Romero²,

Cardoso-Saldaña³

et al. 2017

GMM

View full text Add to dashboard Cite

Vitamin D Inadequacy Is Associated with Significant Coronary Artery Stenosis in a Community-Based Elderly Cohort: The Korean Longitudinal Study on Health and Aging

Cited by 78 publications

References 55 publications

Vitamin D level and extent of coronary stenotic lesions in patients with first acute myocardial infarction

Vitamin D level and extent of coronary stenotic lesions in patients with first acute myocardial infarction

Association between serum vitamin D levels and subclinical coronary atherosclerosis and plaque burden/composition in young adult population

Deficiencia de vitamina D y su asociación con enfermedad arterial coronaria en población mexicana: estudio Genético de la Enfermedad Aterosclerosa

Contact Info

Product

Resources

About