Deficiencia de vitamina D y su asociación con enfermedad arterial coronaria en población mexicana: estudio Genético de la Enfermedad Aterosclerosa

López-Bautista, Fabiola; Posadas‐Romero, Carlos; Cardoso-Saldaña, Guillermo; Juárez-Rojas, Juan Gabriel; Moeini, Aida; Pérez-Hernández, Nonanzit; Rodrı́guez-Pérez, José Manuel; Vargas‐Alarcón, Gilberto; Posadas-Sánchez, Rosalinda

doi:10.24875/gmm.17002930

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…Shor et al (2012) reported the association between vitamin D deficiency and high prevalence of CAD and cardiovascular events, such as myocardial infarction. In contrast, an association between cardiovascular disease and vitamin D deficiency was not found by de Boer et al (2009) and Deleskog et al (2012), which was corroborated by our research group in Mexican individuals with CAD (López-Bautista et al, 2017). It is well known that vitamin D levels are associated with lower levels of primary DNA damage.…”

Section: Discussionsupporting

confidence: 84%

MRE11A Polymorphisms Are Associated With Subclinical Atherosclerosis and Cardiovascular Risk Factors. A Case-Control Study of the GEA Mexican Project

et al. 2019

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DNA damage and subsequent repair pathways have been involved in the initiation and progression of atherosclerosis. Meiotic recombination 11 homolog A ( MRE11A ) gene polymorphisms have been associated with the presence of myocardial infarction. We analyzed five MRE11A gene polymorphisms in 386 individuals with subclinical atherosclerosis and 1093 healthy controls. Under different models, the rs13447720 (Odds ratio = 0.646, P additive = 0.009; Odds ratio = 0.636, P dominant = 0.012; Odds ratio = 0.664, P over–dominant = 0.025; Odds ratio = 0.655, P codominant1 = 0.021) and rs499952 (Odds ratio = 0.807, P additive = 0.032; Odds ratio = 0.643, P codominant2 = 0.034) polymorphisms were associated with a lower risk of subclinical atherosclerosis. On the other hand, the rs2155209 polymorphism was associated with a reduced risk of having a coronary artery calcification score ≥ 100 Agatston units. The rs13447720, rs499952, and rs2155209 polymorphisms, as well as the haplotypes that included the five studied polymorphisms were associated with some clinical and metabolic parameters in both subclinical atherosclerosis and healthy individuals. Our results suggest that the rs13447720 and rs499952 polymorphisms are associated with a decreased risk of developing subclinical atherosclerosis, whereas the rs2155209 is associated with a lower subclinical atherosclerosis severity (coronary artery calcification < 100 Agatston units). MRE11A polymorphisms and haplotypes were associated with clinical and metabolic parameters.

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Section: Discussionsupporting

confidence: 84%

MRE11A Polymorphisms Are Associated With Subclinical Atherosclerosis and Cardiovascular Risk Factors. A Case-Control Study of the GEA Mexican Project

et al. 2019

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“…[ 12 ] Study from Mexico reported a CAD prevalence of 57.6% and 21.2%, respectively. [ 13 ] Moreover, the prevalence of hypovitaminosis D is more frequent in PM women compared to age-matched men. [ 14 ] These findings indicate that hypovitaminosis D is a common occurrence in PM women with CAD.…”

Section: Discussionmentioning

confidence: 99%

Association of vitamin D status with coronary artery disease in postmenopausal women

Xu¹,

Ma³

et al. 2020

Medicine

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The relationship between coronary artery disease (CAD) and low serum 25-hydroxyvitamin D (25(OH)D) levels has emerged. Postmenopausal (PM) women are at increased risk of CAD and vitamin D (VitD) deficiency. To investigate the relationship between CAD and VitD levels in PM women. This case–control study included 93 consecutive female patients aged 50 to 79 years old undergoing coronary angiography for evaluation of CAD and 119 age-matched controls. Serum 25(OH)D concentrations were classed as adequate (serum 25(OH)D: ≥20 ng/mL); insufficient (serum 25(OH)D: 10 to <20 ng/mL); and deficient (serum 25(OH)D: <10 ng/mL). Major cardiovascular risk factors were also explored. CAD occurred in 67/127 (52.8%) patients with VitD deficiency; 21/66 (31.8%) patients that were VitD insufficient; and in 5/19 (26.3%) patients with adequate VitD levels. Multivariate regression analysis suggested that a deficiency of VitD increased CAD (odds ratio = 2.891; 95% confidence interval = 1.459–7.139, P < .001). VitD deficiency should be evaluated in PM women as a possible cause of CAD.

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Recent Advances in Association Between Vitamin D Levels and Cardiovascular Disorders

Agarwal

Hameed

2023

Curr Hypertens Rep

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Deficiencia de vitamina D y su asociación con enfermedad arterial coronaria en población mexicana: estudio Genético de la Enfermedad Aterosclerosa

Cited by 3 publications

References 33 publications

MRE11A Polymorphisms Are Associated With Subclinical Atherosclerosis and Cardiovascular Risk Factors. A Case-Control Study of the GEA Mexican Project

MRE11A Polymorphisms Are Associated With Subclinical Atherosclerosis and Cardiovascular Risk Factors. A Case-Control Study of the GEA Mexican Project

Association of vitamin D status with coronary artery disease in postmenopausal women

Recent Advances in Association Between Vitamin D Levels and Cardiovascular Disorders

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