Vitamin D immunoassay systems: a comparison

Dafterdar, Rofaida; Al-Fayoumi, M; Saadeddin, Salam M.; Khan, Rashid Ali; Alothaim, Ali; Hasanato, Rana; Al-Shangiti, Ali M.; Tamimi, Waleed

doi:10.1080/09674845.2014.11978289

Cited by 7 publications

(6 citation statements)

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“…Currently, the liquid chromatography–tandem mass spectrometry (LC-MS/MS) is the gold standard for measuring total 25(OH)D and other vitamin D metabolites for its high sensitivity and selectivity [33]. In major tertiary hospitals in KSA however, automated immunometric assays are preferred and major differences in results have been confirmed in local studies, mostly by Sadat and colleagues [22, 34, 35]. Well-known standardization systems include the Vitamin D External Quality Assessment Scheme (DEQAS) [36], of which PMCO in KSU is an accredited partner.…”

Section: Vitamin D Measurementmentioning

confidence: 99%

Vitamin D status correction in Saudi Arabia: an experts’ consensus under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases (ESCEO)

et al. 2016

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BackgroundVitamin D deficiency is common in the Middle East and in Saudi Arabia, in particular. While several international recommendations on the management of vitamin D deficiency have been documented and practiced globally, these recommendations should be adapted to the conditions of the Middle Eastern region. To address this challenge, the Prince Mutaib Chair for Biomarkers of Osteoporosis (PMCO) in King Saud University (KSU), Riyadh, KSA, together with local experts and in cooperation with the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO), organized a panel that formulated unified recommendations in the diagnosis and treatment of vitamin D deficiency in the region.MethodsThe selection of local and international experts commenced during the 2nd International Vitamin D Symposium conducted in Riyadh, Saudi Arabia, last January 20-–21, 2016. Reviews of the most recent literature were done, and face-to-face meetings were conducted for revisions and final recommendations.Results: Vitamin D sufficiency is defined as circulating serum 25(OH)D ≥50 nmol (≥20 ng/ml) for the general population and vitamin D adequacy as serum 25(OH)D >75 nmol/L l (>30 ng/ml) for the frail and osteoporotic elderly. Despite overwhelming prevalence of vitamin D deficiency, universal screening is not recommended. Recommendations for the general population, children, pregnant/lactating women, post-menopausal women, the elderly, and those with subsequent metabolic diseases were provided.ResultsVitamin D sufficiency is defined as circulating serum 25(OH)D ≥50 nmol (≥20 ng/ml) for the general population and vitamin D adequacy as serum 25(OH)D >75 nmol/L l (>30 ng/ml) for the frail and osteoporotic elderly. Despite overwhelming prevalence of vitamin D deficiency, universal screening is not recommended. Recommendations for the general population, children, pregnant/lactating women, post-menopausal women, the elderly, and those with subsequent metabolic diseases were provided.ConclusionVitamin D supplementation/correction is advised in all persons whose serum 25(OH)D falls below 50 nmol/l (20 ng/ml), and achieving a target of 75 nmol/l (30 ng/ml) is particularly suited for frail, osteoporotic, and older patients. Conducting well-designed clinical trials in the region that will address economic implications and investigations on the treatment persistence and compliance to vitamin D treatment in the region are encouraged.

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Section: Vitamin D Measurementmentioning

confidence: 99%

Vitamin D status correction in Saudi Arabia: an experts’ consensus under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases (ESCEO)

et al. 2016

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“…It is tempting to suggest, from this data, that the thyroid influences prostate size, were it not for the well-known fact that correlation does not always imply causation. The Journal has a long history of publishing research into vitamin D [15][16][17][18], and this continues with the report from Parra et al [19], who compared the performance of two different methods for measuring serum levels of this micronutrient. Although there was good overall concordance, one method found levels to one of more of these extracts could have immunomodulator properties, perhaps in stimulating the immune response in immunodeficiency.…”

Section: Clinical Chemistrymentioning

confidence: 69%

British Journal of Biomedical Science in 2016. What have we learned?

Blann

2017

British Journal of Biomedical Science

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In 2016, the British Journal of Biomedical Science published 36 reports outlining specific advances in each of the various disciplines within biomedical science. These were one review, 25 original articles, 9 'In Brief' reports and one letter to the Editor. Of these, the majority were in blood science (5 in biochemistry, 7 in haematology and 2 in immunology) and infection science (8 in microbiology, 2 in virology) with a smaller number in cellular sciences (6 in cellular pathology and 2 in cytopathology). Three reports considered both biochemistry and immunology, while another reported an advance in the identification of chromosomal abnormalities. The present report will summarise key aspects of these publications that are of greatest relevance to laboratory scientists.

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“…[3,20] Other immunoassays from Abbott, Roche and Siemens validated in similar studies showed generally good performance, but had some limitations when their performance was challenged with samples with low and high 25OH-D concentrations, heterophilic antibodies or high 25OH-D2 concentrations. [9] Due to the above, the Diasorin Liaison test is an adequate method in order to compare the performance of Fujirebio's Lumipulse G 25-OH Vitamin D assay.…”

Section: Methods Comparisonmentioning

confidence: 96%

Automated measurement of 25-OH Vitamin D on the LUMIPULSE^®G1200: analytical verification and method comparison

Parra

Foj

Filella

2016

British Journal of Biomedical Science

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Vitamin D immunoassay systems: a comparison

Cited by 7 publications

References 2 publications

Vitamin D status correction in Saudi Arabia: an experts’ consensus under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases (ESCEO)

Vitamin D status correction in Saudi Arabia: an experts’ consensus under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases (ESCEO)

British Journal of Biomedical Science in 2016. What have we learned?

Automated measurement of 25-OH Vitamin D on the LUMIPULSE^®G1200: analytical verification and method comparison

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Vitamin D immunoassay systems: a comparison

Cited by 7 publications

References 2 publications

Vitamin D status correction in Saudi Arabia: an experts’ consensus under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases (ESCEO)

Vitamin D status correction in Saudi Arabia: an experts’ consensus under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases (ESCEO)

British Journal of Biomedical Science in 2016. What have we learned?

Automated measurement of 25-OH Vitamin D on the LUMIPULSE®G1200: analytical verification and method comparison

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Automated measurement of 25-OH Vitamin D on the LUMIPULSE^®G1200: analytical verification and method comparison