Vitamin D, Immune Tolerance, and Prevention of Type 1 Diabetes

Badenhoop, Klaus; Kahles, H.; Penna-Martinez, Marissa

doi:10.1007/s11892-012-0322-3

Cited by 36 publications

(23 citation statements)

References 67 publications

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“…For example, the observational studies analyzing associations between exposure to vitamin D during gestation and the risk of T1D development later in life show reduced risk of T1D in individuals taking extra amounts of vitamin D during early infancy, which supports the results of in vitro studies on vitamin D involvement in the early pathogenesis of T1D [7][8][9]. As the main source of vitamin D is its cutaneous synthesis after skin exposure to sunshine, the exposure to sunshine early in life may protect from later development of T1D [10].…”

Section: Introductionsupporting

confidence: 56%

Exposure to sunshine early in life prevented development of type 1 diabetes in Danish boys

Jacobsen¹,

Frederiksen²,

Heitmann

2016

Journal of Pediatric Endocrinology and Metabolism

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Section: Introductionsupporting

confidence: 56%

Exposure to sunshine early in life prevented development of type 1 diabetes in Danish boys

Jacobsen¹,

Frederiksen²,

Heitmann

2016

Journal of Pediatric Endocrinology and Metabolism

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“…In some animal experiments, vitamin D supplements prevented the development and progression of autoimmune disorders such as MS and type 1 diabetes mellitus (8)(9)(10). However, it is unclear whether low vitamin D levels closely correlate with the development of autoimmune thyroid disease (AITD).…”

Section: Introductionmentioning

confidence: 99%

Low Levels of Serum Vitamin D3 Are Associated with Autoimmune Thyroid Disease in Pre-Menopausal Women

Choi

Kim

et al. 2014

Thyroid

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Background: Low serum vitamin D levels have been associated with several autoimmune diseases, but their association with thyroid autoimmunity is unclear. We evaluated the association of serum vitamin D levels with the prevalence of autoimmune thyroid disease (AITD). Methods: Our cross-sectional study included subjects who underwent routine health checkups, which included assays of serum 25-hydroxy vitamin D3 [25(OH)D3] and anti-thyroid peroxidase antibody (TPO-Ab), as well as thyroid ultrasonography (US) between 2008 and 2012 at the Asan Medical Center. We defined AITD according to the levels of TPO-Ab and US findings. Results: A total of 6685 subjects (58% male; 42% female) were enrolled for this study. Overall prevalence of TPO-Ab positivity and both TPO-Ab/US positivity were 10.1% (6.3% male; 15.3% female) and 5.4% (2.3% male; 9.7% female) respectively. In female subjects, mean serum 25(OH)D3 levels were significantly lower in the TPO-Ab(+) (22.0 vs. 23.5 ng/mL, p = 0.030) and TPO-Ab(+)/US(+) groups (21.6 vs. 23.4 ng/mL, p = 0.027) compared with the control group, respectively. According to the levels of serum 25(OH)D3, the prevalence of TPO-Ab positivity (21.2%, 15.5%, and 12.6% in deficient, insufficient, and sufficient group, respectively; p = 0.001) and both TPO-Ab and US positivity (14.7%, 9.9%, and 7.1% in deficient, insufficient, and sufficient group, respectively; p < 0.001) decreased in female subjects. Interestingly, this pattern was significant only in pre-menopausal women ( p = 0.003 and p < 0.001; respectively), but not in postmenopausal women. Multivariate analysis indicated that the adjusted odds ratios (

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“…Several agents have been described to induce a tolerogenic or semimature phenotype in DCs, thereby reducing their capacity to process and present Ags and to fully activate T cells. One such compound is the biologically active form of vitamin D, 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ], which is recognized as a master regulator of bone and calcium/phosphate metabolism and has been thoroughly shown to affect cell growth, differentiation, and function in tissues not related to calcium metabolism, including the immune system (1,2). Indeed, 1,25(OH) 2 D 3 promotes a general suppression of adaptive immune responses, which may offer protection against various autoimmune diseases and limit graft rejection, while enhancing the antimicrobial properties of innate immune cells, such as monocytes and macrophages, acting as the first line of defense against invading microorganisms (2,3).…”

mentioning

confidence: 99%

1,25-Dihydroxyvitamin D3 Promotes Tolerogenic Dendritic Cells with Functional Migratory Properties in NOD Mice

Ferreira

Gysemans

Demengeot

et al. 2014

The Journal of Immunology

112

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The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], is able to promote the generation of tolerogenic mature dendritic cells (mDCs) with an impaired ability to activate autoreactive T cells. These cells could represent a reliable tool for the promotion or restoration of Ag-specific tolerance through vaccination strategies, for example in type 1 diabetes patients. However, successful transfer of 1,25(OH)2D3-treated mDCs (1,25D3-mDCs) depends on the capacity of 1,25(OH)2D3 to imprint a similar tolerogenic profile in cells derived from diabetes-prone donors as from diabetes-resistant donors. In this study, we examined the impact of 1,25(OH)2D3 on the function and phenotype of mDCs originating from healthy (C57BL/6) and diabetes-prone (NOD) mice. We show that 1,25(OH)2D3 is able to imprint a phenotypic tolerogenic profile on DCs derived from both mouse strains. Both NOD- and C57BL/6-derived 1,25D3-mDCs decreased the proliferation and activation of autoreactive T cells in vitro, despite strain differences in the regulation of cytokine/chemokine expression. In addition, 1,25D3-mDCs from diabetes-prone mice expanded CD25+Foxp3+ regulatory T cells and induced intracellular IL-10 production by T cells in vitro. Furthermore, 1,25D3-mDCs exhibited an intact functional migratory capacity in vivo that favors homing to the liver and pancreas of adult NOD mice. More importantly, when cotransferred with activated CD4+ T cells into NOD.SCID recipients, 1,25D3-mDCs potently dampened the proliferation of autoreactive donor T cells in the pancreatic draining lymph nodes. Altogether, these results argue for the potential of 1,25D3-mDCs to restore Ag-specific immune tolerance and arrest autoimmune disease progression in vivo.

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Vitamin D, Immune Tolerance, and Prevention of Type 1 Diabetes

Cited by 36 publications

References 67 publications

Exposure to sunshine early in life prevented development of type 1 diabetes in Danish boys

Exposure to sunshine early in life prevented development of type 1 diabetes in Danish boys

Low Levels of Serum Vitamin D3 Are Associated with Autoimmune Thyroid Disease in Pre-Menopausal Women

1,25-Dihydroxyvitamin D3 Promotes Tolerogenic Dendritic Cells with Functional Migratory Properties in NOD Mice

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