Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease

Cantorna, Margherita T.; McDaniel, Kaitlin; Bora, Stephanie A.; Chen, Jing; James, Jamaal L.

doi:10.1177/1535370214523890

Cited by 116 publications

(114 citation statements)

References 75 publications

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“…24, No. 1 January, 2018 (96-106) supervision; and all authors contributed to data interpretation, critically reviewed the manuscript, and approved the final version of the manuscript.…”

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confidence: 99%

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confidence: 99%

“…22 Thus, vitamin D has been proposed as a potential treatment for IBS 23 as well as IBD. 24 Moreover, in a recent report, the production of the rate-limiting enzyme in serotonin production, TPH, was significantly stimulated by the active hormonal vitamin D metabolite, 1,25-dihydroxyvitamin D (1,25D), in serotonergic neurons. 25 If IBS is linked to an imbalance in serotonin production, vitamin D could play a role in IBS pathogenesis and may provide novel insights into new modes of IBS management.…”

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confidence: 99%

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Gene Expression Profiling and Assessment of Vitamin D and Serotonin Pathway Variations in Patients With Irritable Bowel Syndrome

Dussik

Hockley

Grozić

et al. 2018

J Neurogastroenterol Motil

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Background/AimsIrritable bowel syndrome (IBS) is a multifaceted disorder that afflicts millions of individuals worldwide. IBS is currently diagnosed based on the presence/duration of symptoms and systematic exclusion of other conditions. A more direct manner to identify IBS is needed to reduce healthcare costs and the time required for accurate diagnosis. The overarching objective of this work is to identify gene expression-based biological signatures and biomarkers of IBS. MethodsGene transcripts from 24 tissue biopsy samples were hybridized to microarrays for gene expression profiling. A combination of multiple statistical analyses was utilized to narrow the raw microarray data to the top 200 differentially expressed genes between IBS versus control subjects. In addition, quantitative polymerase chain reaction was employed for validation of the DNA microarray data. Gene ontology/pathway enrichment analysis was performed to investigate gene expression patterns in biochemical pathways. Finally, since vitamin D has been shown to modulate serotonin production in some models, the relationship between serum vitamin D and IBS was investigated via 25-hydroxyvitamin D (25[OH]D) chemiluminescence immunoassay. ResultsA total of 858 genetic features were identified with differential expression levels between IBS and asymptomatic populations. Gene ontology enrichment analysis revealed the serotonergic pathway as most prevalent among the differentially expressed genes. Further analysis via real-time polymerase chain reaction suggested that IBS patient-derived RNA exhibited lower levels of tryptophan hydroxylase-1 expression, the enzyme that catalyzes the rate-limiting step in serotonin biosynthesis. Finally, mean values for 25(OH)D were lower in IBS patients relative to non-IBS controls. Conclusions IntroductionIrritable bowel syndrome (IBS) is one of the most common gastrointestinal (GI) disorders afflicting between 10-15% of the global population.1 Primary symptoms associated with IBS include abdominal pain and irregular bowel movements that, based upon the predominant symptom pattern, may be utilized to subdivide the syndrome into 3 classifications: diarrhea-predominant IBS (IBS-D), constipation-predominant IBS (IBS-C), and mixed IBS (IBS-M).2 However, the subtype of IBS that an individual is classified does not necessarily remain static; patients can evolve over time from diarrheic or mixed type to constipative. The chronic and erratic nature of IBS can lead to a multitude of secondary effects, such as depression, anxiety, poor quality of life, insomnia, and sexual dysfunction. 3Using the current diagnostic model for IBS, the Rome IV criteria, symptoms must be present for 3 months or longer before diagnoses can be established. 4 Other disorders with IBS-like symptoms that should be excluded include celiac disease, inflammatory bowel disease (IBD), malabsorptive disorders, pelvic floor disorders, and colon cancer. Further, once diagnosed, treatment for IBS patients may be mostly palliative in nature with dietary changes...

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“…24, No. 1 January, 2018 (96-106) supervision; and all authors contributed to data interpretation, critically reviewed the manuscript, and approved the final version of the manuscript.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Gene Expression Profiling and Assessment of Vitamin D and Serotonin Pathway Variations in Patients With Irritable Bowel Syndrome

Dussik

Hockley

Grozić

et al. 2018

J Neurogastroenterol Motil

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“…66 Furthermore vitamin D can inhibit IFN-g production and is also effective in regulating gastrointestinal homeostasis by inducing regulatory T cells and innate immune responses, as well as favoring epithelial cell integrity, and a healthy composition of the gut microbiota. 67 Furthermore, vitamin D appears to be a potent antioxidant, as it inhibits the formation of free radicals by nitric oxide synthase and gamma-glutamyl transpeptidase. 60 And finally, vitamin D appears to have an important role in brain development by regulating the level of neurotrophic factors.…”

Section: 49mentioning

confidence: 99%

Anti-inflammatory nutritional intervention in patients with relapsing-remitting and primary-progressive multiple sclerosis: A pilot study

Riccio

Rossano

Larocca

et al. 2016

Exp Biol Med (Maywood)

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The aim of this work was to assess the influence of nutritional intervention on inflammatory status and wellness in people with multiple sclerosis. To this end, in a seven-month pilot study we investigated the effects of a calorie-restricted, semi-vegetarian diet and administration of vitamin D and other dietary supplements (fish oil, lipoic acid, omega-3 polyunsaturated fatty acids, resveratrol and multivitamin complex) in 33 patients with relapsing-remitting multiple sclerosis and 10 patients with primary-progressive multiple sclerosis. At 0/3/6 months, patients had neurological examination, filled questionnaires and underwent anthropometric measurements and biochemical analyses. Serum fatty acids and vitamin D levels were measured as markers of dietary compliance and nutritional efficacy of treatment, whereas serum gelatinase levels were analyzed as markers of inflammatory status. All patients had insufficient levels of vitamin D at baseline, but their values did not ameliorate following a weekly administration of 5000 IU, and rather decreased over time. Conversely, omega-3 polyunsaturated fatty acids increased already after three months, even under dietary restriction only. Co-treatment with interferon-beta in relapsing-remitting multiple sclerosis was irrelevant to vitamin D levels. After six months nutritional treatment, no significant changes in neurological signs were observed in any group. However, serum levels of the activated isoforms of gelatinase matrix metalloproteinase-9 decreased by 59% in primary-progressive multiple sclerosis and by 51% in relapsing-remitting multiple sclerosis patients under nutritional intervention, including dietary supplements. This study indicates that a healthy nutritional intervention is well accepted by people with multiple sclerosis and may ameliorate their physical and inflammatory status.

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“…Ainda são raras as evidências de que esta vitamina possa atuar no estado inflamatório via modulação da microbiota intestinal (LY et al, 2011;CANTORNA et al, 2014). Reconhecendo a participação da microbiota na gênese de doenças crônicas, que têm a inflamação subclínica como mecanismo fisiopatológico, é de interesse aprofundar o conhecimento sobre as interrelações entre a vitamina D, microbiota intestinal e doenças crônicas.…”

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Vitamina D na modulação da microbiota intestinal: associações com os perfis inflamatório e cardiometabólico

Luthold¹

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Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease

Cited by 116 publications

References 75 publications

Gene Expression Profiling and Assessment of Vitamin D and Serotonin Pathway Variations in Patients With Irritable Bowel Syndrome

Gene Expression Profiling and Assessment of Vitamin D and Serotonin Pathway Variations in Patients With Irritable Bowel Syndrome

Anti-inflammatory nutritional intervention in patients with relapsing-remitting and primary-progressive multiple sclerosis: A pilot study

Vitamina D na modulação da microbiota intestinal: associações com os perfis inflamatório e cardiometabólico

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