Anti-inflammatory nutritional intervention in patients with relapsing-remitting and primary-progressive multiple sclerosis: A pilot study

Riccio, P.; Rossano, Rocco; Larocca, Marilena; Trotta, Vincenzo; Mennella, Ilario; Vitaglione, Paola; Ettorre, Michele; Graverini, Antonio; Santis, Alessandro De; Monte, Elisabetta Di; Coniglio, Maria Gabriella

doi:10.1177/1535370215618462

Cited by 71 publications

(54 citation statements)

References 81 publications

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“…A pilot study evaluated the effects of caloric restriction to 1700-1800 kcal diet in 33 patients RRMS and 10 patients with PPMS [53]. The diet encouraged intake of protein from fish rather than meat in combination supplementation of vitamin D, lipoic acid, fish oil, omega-3 PUFA, resveratrol, and multivitamin complex.…”

Section: Hyperbolic Diet and Caloric Restrictionmentioning

confidence: 99%

Dietary Interventions and Multiple Sclerosis

Altowaijri

Fryman²,

Yadav

2017

Curr Neurol Neurosci Rep

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Multiple Sclerosis (MS) is a chronic, disabling neurologic disease that has its onset in young adulthood. While the knowledge about underlying pathogenesis of MS has improved significantly over the last few decades, the exact cause still eludes us. Despite the availability of several United States Food and Drug Administration-approved disease-modifying therapies (DMT) for MS in the last two decades, the disease remains disabling for many. DMT use is limited by its partial effectiveness, significant side effects in many cases, and high cost that leads people with MS (PwMS) to look for alternative management options. Dietary intervention as a possible mode to help MS seems very appealing to PwMS; however, scientific data supporting this notion remains sparse. New information on the role of various non-MS health factors, especially vascular disease risk factors such as hypertension, hyperlipidemia, salt intake, and obesity, that may play a role in MS pathogenesis appears very intriguing as it may partly explain the heterogeneity seen in MS activity and disability. This review will highlight the emerging information on various dietary approaches that may affect MS and their possible underlying mechanism.

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Section: Hyperbolic Diet and Caloric Restrictionmentioning

confidence: 99%

Dietary Interventions and Multiple Sclerosis

Altowaijri

Fryman²,

Yadav

2017

Curr Neurol Neurosci Rep

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“…A pesar de ello, aún a día de hoy, el tratamiento de la EM no incluye la combinación de fármacos con recomendaciones dietéticas o cambios en el estilo de vida, lo cual puede ser debido a la falta de información (7).…”

Section: Introductionunclassified

Efectos del estado nutricional en la enfermedad de la esclerosis múltiple: revisión sistemática

2018

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Ródenas Esteve I, Wanden-Berghe C, Sanz-Valero J. Efectos del estado nutricional en la enfermedad de la esclerosis múltiple: revisión sistemática. ResumenObjetivo: revisar la literatura científica existente sobre los efectos del estado nutricional en la esclerosis múltiple. . La calidad de los artículos se evaluó mediante el cuestionario STROBE. Se completó la búsqueda con la consulta a expertos y la revisión de la bibliografía de los artículos seleccionados. Resultado: de las 160 referencias recuperadas, tras aplicar los criterios de inclusión y exclusión, se seleccionaron para la revisión 29 artículos. La gran mayoría de los estudios determinaron los niveles de vitamina D. Otros centraron su búsqueda en averiguar qué déficits de nutrientes podrían estar relacionados con el desarrollo de la esclerosis múltiple. Conclusiones: la vitamina D puede influir en la mejora de la esclerosis múltiple. La luz solar y la actividad física serían factores importantes, junto con el estado nutricional, en el curso de dicha enfermedad. Sería necesaria la generación de nuevos trabajos específicos que profundizaran en el tema para averiguar más acerca de la relación existente entre el estado nutricional y la esclerosis múltiple. ). The quality of the selected articles was discussed using the STROBE questionnaire. The search was completed through experts inquiry and additional review of the bibliographic references included in the selected papers. The concordance between authors (Kappa index) had to be higher than 80% for inclusion in this review. Results: Of the 160 references recovered, after applying inclusion and exclusion criteria, 29 articles were selected for review. Concordance between evaluators was 100.00%. The most studies established vitamin D levels. Others focused their research on finding out which nutrient deficits might be related to the multiple sclerosis development. Conclusions: Vitamin D may influence multiple sclerosis improvement. Sunlight and physical activity would be important factors, with nutritional status, in the course of this disease. It is necessary to produce new specific works that will delve into the subject to find out more about the relationship between nutritional status and multiple sclerosis.

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“…In this respect, a low-fat diet and supplementation of pharmacological therapy with antioxidant and anti-inflammatory natural compounds has proved to be highly promising in the treatment of MS patients. 12 Many MMPs are constitutively expressed in some cell types, but their levels may be induced in response to endogenous or exogenous stimuli, such as growth factors, hormones, steroids, cytokines, chemokines, pathogens and cell-cell or cell-ECM interactions. Most of the transcriptional regulation mechanisms, mediated by soluble factors, occur mainly following the binding of the stimulating factors to their cell-surface receptors.…”

Section: Box 1 Treatment In Multiple Sclerosismentioning

confidence: 99%

“…4,5 Several studies have shown that both anti-MS-specific therapies [6][7][8][9] and some antioxidant and anti-inflammatory compounds have the ability to downregulate MMPs, suggesting that inhibition of MMPs may represent an additional mechanism by which these agents decrease the development of new CNS lesions in the course of MS. [10][11][12] In this review, we summarize the general characteristics of the different MMPs and their regulatory mechanisms. The pathogenic role of MMPs in the development and progression …”

Section: Introductionmentioning

confidence: 99%

“…In another study, the supplementation of ω3 PUFA in patients with RR-MS significantly decreased MMP-9 levels in serum and supernatants from peripheral blood mononuclear cells. 49 Recently, Riccio et al 12 investigated the influence of nutritional intervention on inflammatory status and wellness in RR-MS patients under IFNβ treatment and in untreated PP-MS patients. In particular, in this pilot study they investigated the effects of a calorie-restricted, semivegetarian diet, supplemented with vitamin D, fish oil, LA, ω3 PUFA, resveratrol and a multivitamin complex.…”

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confidence: 99%

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Metalloproteinases and their inhibitors as therapeutic targets for multiple sclerosis: current evidence and future perspectives

Latronico¹,

Liuzzi²

2017

MNM

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Abstract:The treatment of multiple sclerosis (MS) has seen important changes in the last two decades with the introduction of several drugs able to modify the evolution of this disease. Current MS therapies primarily target the peripheral immune response, although it has been suggested that their efficacy could be in part the result of the beneficial effect on other nonspecific targets, such as matrix metalloproteinases (MMPs). Numerous experimental studies have suggested that MMPs may be involved in MS pathogenesis by contributing to blood-brain barrier disruption, migration of leukocytes into the central nervous system, demyelination and axonal damage. Therefore, MMPs have been considered important therapeutic targets in the course of MS. In this respect, different attempts have been made to develop synthetic, low-molecular-weight inhibitors of MMPs for the potential treatment of diseases in which MMPs play a major role. However, technical difficulties, side effects and reduced patient compliance because of parenteral administration have greatly limited the development in the clinical practice of specific anti-MMP drugs. By contrast, interesting results have been obtained with compounds that are already used in the clinical practice, such as MS drugs and natural compounds with anti-inflammatory and antioxidant activity. Here, we discuss the evidence and potential mechanisms for altered MMP function in MS. Furthermore, we outline the possible medical implications for the use of compounds that target MMP activity and we propose that together with anti-MS drugs, other compounds with anti-inflammatory and antioxidant properties, such as natural ω3 fatty acids, polyphenols and tetracyclines, which inhibit MMP functions, might represent potential therapeutic approaches to mitigate MMP-related damage during MS.

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Anti-inflammatory nutritional intervention in patients with relapsing-remitting and primary-progressive multiple sclerosis: A pilot study

Cited by 71 publications

References 81 publications

Dietary Interventions and Multiple Sclerosis

Dietary Interventions and Multiple Sclerosis

Efectos del estado nutricional en la enfermedad de la esclerosis múltiple: revisión sistemática

Metalloproteinases and their inhibitors as therapeutic targets for multiple sclerosis: current evidence and future perspectives

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