Vitamin D Every Day to Keep the Infection Away?

Kroner, Juliana de Castro; Sommer, Andrea; Fabri, Mario

doi:10.3390/nu7064170

Cited by 46 publications

(46 citation statements)

References 121 publications

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“…It is difficult to clarify whether the immunomodulatory or antioxidative effect of vitamin D is more predominant during the process. However, the results of vitamin D supplementation trials did not always demonstrate consistent protective effects [38]. Prevention through vaccination remains the best strategy to minimize the adverse consequences associated with infections.…”

Section: Vitamin D and Immune Dysfunction In Ckdmentioning

confidence: 99%

Pleiotropic Effects of Vitamin D in Kidney Disease

Wu¹,

Lu²

2017

A Critical Evaluation of Vitamin D - Clinical Overview

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Vitamin D is metabolized in the liver and kidneys and then converted to the active form, 1.25-dihydroxyvitamin D [1.25(OH)2D]. Chronic kidney disease patients usually lack both 25-hydroxyvitamin D [25(OH)D] and 1.25(OH)2D due to impaired renal function and 1α-hydroxylase deficiency. Chronic kidney disease patients have a high incidence of cardiovascular and infectious morbidities. Increasing evidence indicates a relationship between vitamin D deficiency and cardiovascular and infectious mortality risks. Vitamin D may have significant biological effects beyond its traditional roles on mineral and bone metabolism. Many extrarenal cells have the capability to produce local active 1.25(OH)2D in an intracrine or paracrine fashion. Vitamin D has a significant association with nonskeletal diseases, such as immunodeficiency, metabolic syndrome, insulin resistance, diabetes, hyperlipidemia, cardiovascular disease, proteinuria, and acute kidney injury. This article aims to review and summarize the pleiotropic effects of vitamin D in patients with kidney disease, particularly the immunological, metabolic, cardiovascular, and renal effects.

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Section: Vitamin D and Immune Dysfunction In Ckdmentioning

confidence: 99%

Pleiotropic Effects of Vitamin D in Kidney Disease

Wu¹,

Lu²

2017

A Critical Evaluation of Vitamin D - Clinical Overview

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“…Active Vitamin D has immune modulatory effects in CKD patients which will ameliorate renal fibrosis and slow-down proteinuria development. This can be done by enhancing Th2 cell differentiation, decreasing IL-6 expression, decreasing inflammatory and oxidative stress, altering T cell behavior, thus favoring tolerance development and reduce proinflammatory activity (140,(143)(144)(145).…”

Section: Vitamin D and Kidney Diseasementioning

confidence: 99%

“…Vitamin D may increase activity of Tregs and inhibits activity of IL-17. Also, Vitamin D is required for the development of natural killer T cells (NKT) and increased secretion of IL-4 and IFN-γ [98,100,145,176,177].…”

Section: -Vitamin D and Autoimmunitymentioning

confidence: 99%

Vitamin D and Immune System

Mosaad¹,

Mostafa²,

Elwasify³

et al. 2017

Vitam Miner

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“…It has long been recognized for its role in bone mineralization and the prevention of rickets. Furthermore, as it is essential for calcium absorption, vitamin D is reported to modulate both innate and adaptive immune responses (Baeke, Takiishi, Korf, Gysemans, & Mathieu, 2010;Kroner, Sommer, & Fabri, 2015). The expression of its receptor in several immune cells such as APC (antigen-presenting cells), B and T cells highlights its importance for a pathological situation.…”

Section: Vitamin D Receptor (Vdr)mentioning

confidence: 99%

Current immunogenetic predisposition to tuberculosis in the Moroccan population

Qrafli

Najimi

Elaouad

et al. 2017

Int J Immunogenetics

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Tuberculosis (TB) is a serious infectious disease that kills approximately two million people per year, particularly in low- and middle-income countries. Numerous genetic epidemiology studies have been conducted of many ethnic groups worldwide and have highlighted the critical impact of the genetic environment on TB distribution. Many candidate genes associated with resistance or susceptibility to TB have been identified. In Morocco, where TB is still a major public health problem, various observations of clinical, microbiological and incidence distribution are heavily affected by genetic background and external environment. Morocco has almost the same clinical profile as do other North African countries, mainly the increase in more extrapulmonary than pulmonary forms of the diseases, when compared to European, Asian or American populations. In addition, a linkage analysis study that examined Moroccan TB patients identified a unique chromosome region that had a strong association with the risk of contracting TB. Other genes in the Moroccan population that were found to be associated seem to be involved predominantly in modulating the innate immunity. In this review, we appraise the major candidate genes that have been reported in Moroccan immunogenetic studies and discuss their updated role in TB, particularly during the first phase of the immune response to Mycobacterium tuberculosis (Mtb) infection.

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Vitamin D Every Day to Keep the Infection Away?

Cited by 46 publications

References 121 publications

Pleiotropic Effects of Vitamin D in Kidney Disease

Pleiotropic Effects of Vitamin D in Kidney Disease

Vitamin D and Immune System

Current immunogenetic predisposition to tuberculosis in the Moroccan population

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