Vitamin D Depletion Aggravates Hypertension and Target‐Organ Damage

Andersen, Louise Bjørkholt; Przybył, L; Haase, Nadine; Versen‐Höynck, Frauke von; Qadri, Fatimunnisa; Jørgensen, Jan Stener; Sørensen, Grith Lykke; Fruekilde, Palle Bach Nielsen; Poglitsch, Marko; Szijártó, István András; Gollasch, Maik; Peters, J; Müller, Dominik N.; Christesen, Henrik Thybo; Dechend, Ralf

doi:10.1161/jaha.114.001417

Cited by 41 publications

(46 citation statements)

References 56 publications

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“…Vitamin D affects the genes responsible for the development of placenta (30), and so vitamin D insufficiency contributes to impaired growth and function of the placenta, possibly leading to preeclampsia and preterm delivery. Another potential pathophysiological pathway is that vitamin D insufficiency results in an inverse endocrine regulator of the renin-angiotensin system that aggravates hypertension (17) and thereby may aggravate pregnancy-induced hypertensive disorders (7). The number of cases of preeclampsia was numerically higher among women with vitamin D insufficiency, but this was not significant.…”

Section: Discussionmentioning

confidence: 99%

“…One woman in early and eight women in late pregnancy did not have blood samples collected for various other reasons. Among the healthy women blood was sampled at 15 (range [10][11][12][13][14][15][16][17][18][19] weeks.…”

Section: Methodsmentioning

confidence: 99%

“…Preeclampsia is characterized by hypertension and is a frequent cause of preterm delivery. Clinical studies have demonstrated an inverse relationship between vitamin D levels and the blood pressure outside pregnancy (15,16), a mechanism that has been linked to the renin-angiotensin-aldosterone system (16,17).…”

Section: Key Messagementioning

confidence: 99%

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Vitamin D insufficiency, preterm delivery and preeclampsia in women with type 1 diabetes – an observational study

Vestgaard

Secher

Ringholm

et al. 2017

Acta Obstet Gynecol Scand

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Introduction. The aim of this study was to evaluate whether vitamin D insufficiency is associated with preterm delivery and preeclampsia in women with type 1 diabetes. Material and methods. An observational study of 198 pregnant women with type 1 diabetes. 25-Hydroxy-Vitamin D and HbA1c were measured in blood samples in early (median 8 weeks, range 5-14) and late (34 weeks, range 32-36) pregnancy. Kidney involvement (microalbuminuria or nephropathy) at inclusion, smoking status at inclusion, preterm delivery (<37 weeks) and preeclampsia (blood pressure ≥140/ 90 mmHg and proteinuria) were registered. Vitamin D supplementation of 10 lg daily was routinely recommended. Results. Thirty-nine (20%) of the 198 women delivered preterm and 16 (8%) developed preeclampsia. Vitamin D insufficiency (<50 nmol/L) was present in 68 women (34%) in early pregnancy and in 73 women (37%) in late pregnancy. Preterm delivery occurred more frequently in women with vitamin D insufficiency in late pregnancy (27% vs. 15%, crude odds ratio 2.1; 95% confidence interval 1.0-4.3, p = 0.04). After adjustment for preexisting kidney involvement, HbA1c in late pregnancy and smoking the association became nonsignificant (adjusted odds ratio 1.8; 95% confidence interval 0.8-3.7). Preeclampsia developed in 11% of women with vitamin D insufficiency vs. 6% of the remaining women (crude odds ratio 1.8; 95% confidence interval 0.9-4.1, p = 0.25). Conclusion. In women with type 1 diabetes, preterm delivery was twice as frequent in women with vitamin D insufficiency in late pregnancy in crude analysis, but in this small study, low vitamin D was not independently associated with preterm birth or preeclampsia.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Vitamin D insufficiency, preterm delivery and preeclampsia in women with type 1 diabetes – an observational study

Vestgaard

Secher

Ringholm

et al. 2017

Acta Obstet Gynecol Scand

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“…Vitamin D directly affects smooth muscle cells by inhibiting proliferation that leads to calcification leading to cardiovascular diseases (CVD) 21,28 . In an analysis of the Third National Health and Nutrition Examination Survey (NHANES III 1988-1994 Resistant hypertension, is considered as a major risk factor for CVD 9,10,21,28 . Prolonged vitamin D3 deficiency or even short-term severe vitamin D deficiency can result in development of hypertension via modulation of the RAS system 9,31 .…”

Section: Effects Of Vitamin D Deficiency In High Risk Groups For Covimentioning

confidence: 99%

Role of Vitamin D in Pathogenesis and Severity of COVID-19 Infection

Ghavideldarestani¹,

Honardoost²,

Khamseh³

2020

Preprint

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Coronavirus disease (COVID-19) is an infectious disease caused by a new virus which causes respiratory illness. Older adults and people who have previous chronic medical conditions are at higher risk for more serious complications from COVID-19.Hypovitaminosis D is attributed to the increased risk of lung injury and acute respiratory distress syndrome (ARDS) as well as diabetes, Cardiovascular event and associated comorbidities, which are the main causes of severe clinical problem in COVID-19 patients. Considering the protective role of vitamin D through modulating the innate and adaptive immune system as well as inhibition of Renin Angiotensin System (RAS), vitamin D supplementation might boost the immune system of COVID-19 patients and reduce severity of the disease in vitamin D deficient individuals.

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“…This aggravated hypertension lead to target-organ damage[114]. They concluded that even a short-term severe Vitamin D deficiency may directly promote hypertension and impact the RAAS system that could contribute to target-organ damage[127]. Another study revealed that after 8-weeks of cholecalciferol therapy in hypertensive patients with hypovitaminosis D, there was a significant reduction in circulating renin-angiotensin-aldosterone and improved vascular function compared to controls[128].…”

mentioning

confidence: 99%

A Review: Molecular Concepts and Common Pathways Involving Vitamin D in the Pathophysiology of Preeclampsia

Washington¹,

Ghosh²,

Reeves³

2018

OJOG

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Preeclampsia is one of the most serious conditions at the end of pregnancy, causing increased perinatal morbidity and mortality to the pregnant mother and her product of conception. It remains a high-risk disease in ethnic minorities worldwide. Conception involves fetal invasion and implantation, followed by an actively forming and shedding decidua, an important uterine activity facilitating placental development. Dysregulation in conception mediates functional changes that induce onset of preeclampsia. The pathophysiology of preeclampsia primarily results from impaired trophoblastic invasion and implantation with subsequent vasculopathy. These events trigger exaggerated ischemic, inflammatory and immunologic events in the placenta bed that disrupt implantation. As the underlying mechanism(s) of preeclampsia remain obscure, there is increasing evidence that Vitamin D deficiency during pregnancy potentiates hypertensive states that could lead to the development of preeclampsia. As a prohormone, Vitamin D regulates molecular events within central pathophysiological pathways of implantation and vascular development. We review shared pathways involving Vitamin D modulation of pathologic events in implantation associated with preeclampsia. Understanding the causal mechanisms between Vitamin D and preeclampsia during early stages of conception could allude to development of candidate markers for treatment or screening, and decipher "hot spots" for research and intervention of, at-risk pregnant mothers.

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Vitamin D Depletion Aggravates Hypertension and Target‐Organ Damage

Cited by 41 publications

References 56 publications

Vitamin D insufficiency, preterm delivery and preeclampsia in women with type 1 diabetes – an observational study

Vitamin D insufficiency, preterm delivery and preeclampsia in women with type 1 diabetes – an observational study

Role of Vitamin D in Pathogenesis and Severity of COVID-19 Infection

A Review: Molecular Concepts and Common Pathways Involving Vitamin D in the Pathophysiology of Preeclampsia

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