Vitamin d deficiency in psoriatic patients -A case control study

Hassan, Rishi; Kallan, Febin; Subramanian, Siva; Pillai, Rathish T; Dinachandran, Athira

doi:10.18231/2581-4729.2019.0009

Cited by 3 publications

(4 citation statements)

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“…22,23 Studies conducted in India, and Nepal, showed a similar outcome. 24,25 Additionally, our findings were consistent with the other research, which demonstrated lower serum levels of 25-hydroxyvitamin D in psoriasis patients than in control. [26][27][28] In contrast to what we have observed, some studies have not shown any link between 25-hydroxy vitamin D levels and the risk of developing psoriasis.…”

Section: Discussionsupporting

confidence: 92%

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The CDX2 G allele and the FoKI F allele of the VDR gene are more prevalent and related to changes in vitamin D levels in patients with psoriasis vulgaris: A pilot study

AbdElneam,

Al‐Dhubaibi,

Bahaj

et al. 2023

Skin Research and Technology

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Background and aimsPsoriasis is a chronic, non‐contagious autoimmune condition marked by dry, itchy,erythematous and scaly plaques. From modest, localized plaques to total body coverage, the severity of psoriasis varies. Plaque, guttate, inverted, pustular, and erythrodermic psoriasis are the five primary kinds. About 90% of cases are of plaque psoriasis, commonly known as psoriasis vulgaris. Study aims to determine the impact of an rs2228570 (FokI) variant and an rs11568820 (CDX2) variant on serum vitamin D levels (SVD) in patients with psoriasis, and the correlation between the two variants and disease severity.MethodsA case‐control study consisting of 95 psoriasis vulgaris patients and 84 healthy controls. The clinical investigation, molecular genetics analysis, and biochemical analysis were done for both groups.ResultsSVD levels were significantly decreased in psoriasis patients group. FokI genotypes analysis, we found no significant variance between groups. CDX2 G/G genotype is more prevalent in patients than controls. Moderate psoriasis vulgaris patients with CDX2 G/G genotypes have higher SVD levels than CDX2 G/A, and CDX2 A/A p = 0.003.ConclusionThe study found a difference in vitamin D levels between patients and healthy subjects, as well as a difference in vitamin D levels with different FoKI and CDX2 genotypes.

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Section: Discussionsupporting

confidence: 92%

“…revealed comparable findings 22,23 . Studies conducted in India, and Nepal, showed a similar outcome 24,25 . Additionally, our findings were consistent with the other research, which demonstrated lower serum levels of 25‐hydroxyvitamin D in psoriasis patients than in control 26–28 .…”

Section: Discussionsupporting

confidence: 91%

The CDX2 G allele and the FoKI F allele of the VDR gene are more prevalent and related to changes in vitamin D levels in patients with psoriasis vulgaris: A pilot study

AbdElneam,

Al‐Dhubaibi,

Bahaj

et al. 2023

Skin Research and Technology

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“…The major finding of this study is the significantly reduced serum vitamin D level among psoriasis patients in comparison with control groups even after adjusting for confounding factors as well as various cardiovascular risk factors. Similar findings were also put forward in studies by Orgaz Molina et al 1 and Chandrasekhar et al 18 A similar finding was also observed in Prabha et al 5 and Hassan et al’s 6 studies conducted in India which has a similar geographical latitude as Nepal. But the limitation of these studies is that they did not consider the confounding factors and other cardiovascular risk factors that influence the serum 25(OH) D level greatly.…”

Section: Discussionsupporting

confidence: 85%

“…Moreover these studies were limited by small sample size and clinical and methodological heterogenecity among the study groups. 4 Further, among case-control studies published between 2019 and 2021, few of them showed significant association between 25(OH) D levels and psoriasis, [5][6][7][8][9] while other remaining studies did not show a significant association between level of 25(OH) D with psoriasis. [10][11][12][13][14] Hence in conclusion from the literature review of clinical studies available to date, the association between psoriasis and vitamin D is still controversial.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Vitamin D Level in Patients with Psoriasis and Its Correlation with Disease Severity: A Case–Control Study

Pokharel¹,

Agrawal²,

Pandey³

et al. 2022

PTT

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Background Chronic plaque psoriasis is a chronic inflammatory skin disorder. Vitamin D has been shown to have effects on keratinocyte differentiation as well as immune regulation in the skin. Objective The main objective of this study was to assess the 25hydroxyvitamin D [25 (OH) D] level in patients with psoriasis in comparison with healthy control subjects. Materials and Methods This case–control study included 180 persons (120 cases and 60 age- and sex-matched control subjects) from outpatient department of BPKIHS, a tertiary care hospital in eastern Nepal. Severity of psoriatic skin lesions was assessed using psoriasis area severity index (PASI) scoring. Serum vitamin D level was assessed by chemiluminescent immunoassay. Results The mean serum 25(OH) D levels in psoriatic patients and controls were 19.57 ± 6.85 ng/mL and 23.63 ± 6.40 ng/mL, respectively. The difference was statistically significant even after adjusting for confounding factors in a multivariate analysis (aOR 2.929, 95% CI 1.376–6.230). Low serum 25(OH) D levels were negatively associated with the severity of disease (r= −0.628, P= 0.01). Conclusion Serum 25(OH) D levels are significantly lower in psoriatic patients than in healthy control subjects. Deficiency of serum 25(OH) D was associated with severity of disease with an inverse relationship with PASI score.

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Evaluation of Efficacy and Safety of Oral Vitamin D3 and Vitamin E as an Add-on-Therapy to Methotrexate in Patients of Moderate Chronic Plaque Psoriasis

Narang,

RANI,

KATARIA

et al. 2023

Asian J Pharm Clin Res

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Objective: This study was conducted with the aim to evaluate the efficacy and safety of oral Vitamin D3 and Vitamin E as an add-on-therapy to methotrexate (MTX) in patients of moderate chronic plaque psoriasis. Methods: In this prospective, open-labeled, randomized, and comparative clinical study, a total of 120 patients of age 20–60 years with moderate chronic plaque psoriasis attending the dermatology outpatient department were randomly allocated into three groups of 40 each, i.e., Group M, Group D, and Group E. Group M received MTX (7.5 mg) tablet orally weekly, Group D received MTX (7.5 mg) and Vitamin D3 (60,000 IU) sachet orally weekly, and Group E received MTX (7.5 mg) weekly and Vitamin E (400 mg) daily. Efficacy assessment was done through the following primary parameters-psoriasis area and severity index (PASI) score, dermatology life quality index (DLQI), and psoriasis disability index (PDI), and secondary parameters such as Vitamin D deficiency and insufficiency among the study participants and improvement of serum 25(OH)D concentration. Adverse events were monitored. Results: PASI and DLQI were calculated at the time of recruitment (baseline), 1 month, 2 months, 3 months, and 4 months, and PDI and serum Vitamin D were calculated at baseline and 4 months. On intergroup comparison of PASI score and PDI, statistically significant results were seen at 4 months. DLQI showed significant results at 2, 3, and 4 months. Significant results were found in Group D which signifies improvement in serum Vitamin D levels. Mild side effects were seen at the end of 4 months. Conclusion: The present study suggested that Vitamin D as an add-on therapy was found to cause a significant reduction in psoriatic lesions. It could be a promising drug in patients with psoriasis to improve the psoriatic lesions, when combined can reduce the dose of MTX, thereby minimizing the side effects.

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Vitamin d deficiency in psoriatic patients -A case control study

Cited by 3 publications

References 0 publications

The CDX2 G allele and the FoKI F allele of the VDR gene are more prevalent and related to changes in vitamin D levels in patients with psoriasis vulgaris: A pilot study

The CDX2 G allele and the FoKI F allele of the VDR gene are more prevalent and related to changes in vitamin D levels in patients with psoriasis vulgaris: A pilot study

Assessment of Vitamin D Level in Patients with Psoriasis and Its Correlation with Disease Severity: A Case–Control Study

Evaluation of Efficacy and Safety of Oral Vitamin D3 and Vitamin E as an Add-on-Therapy to Methotrexate in Patients of Moderate Chronic Plaque Psoriasis

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