Assessment of Vitamin D Level in Patients with Psoriasis and Its Correlation with Disease Severity: A Case–Control Study

Pokharel, Ranju; Agrawal, Sudha; Pandey, Prajwal; Lamsal, Madhab

doi:10.2147/ptt.s369426

Cited by 3 publications

(5 citation statements)

References 15 publications

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Section: General Characteristics Of Included Studies and Patientsmentioning

confidence: 99%

“…Figure 1 reports the sorting process of the publications included in the meta-analysis. A total of 18 case-control studies [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44], 5 cross-sectional cohort studies [45][46][47][48][49], and 4 RCTs [50][51][52][53] were included, and a general description of all studies is provided in Tables 1 and 2. Overall, 9741 subjects were included in the meta-analysis and were allocated in two different analyses: 25(OH)D level analysis with a total of 9408 subjects (patients with psoriasis 1876 (19.9%) and healthy controls 7532 (80.1%)) and vitamin D supplement efficacy analysis in patients with psoriasis (total of 333: number of patients receiving vitamin D supplements: 173 (52.0%) and patients receiving placebo: 160 (48.0%)).…”

Section: General Characteristics Of Included Studies and Patientsmentioning

confidence: 99%

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Psoriasis and Vitamin D: A Systematic Review and Meta-Analysis

Formisano,

Proietti,

Borgarelli

et al. 2023

Nutrients

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Psoriasis is a chronic immune-dysregulated inflammatory disease and hypovitaminosis D is considered a risk factor. We conducted an online database search to review and meta-analyze the relationship between vitamin D, other bone metabolism parameters, and psoriasis. The efficacy of oral vitamin D supplementation in improving Psoriasis Area and Severity Index (PASI) was also evaluated. Non-original articles, case reports, and animal studies were excluded. Bias risk was assessed according to the Cochrane Collaboration’s tool and the Newcastle–Ottawa scale in randomized controlled trials (RCTs) and case–control studies, respectively. Unstandardized mean differences were used for data synthesis. Twenty-three studies reported serum 25 hydroxyvitamin D (25(OH)D) levels in 1876 psoriasis patients and 7532 controls. Psoriasis patients had significantly lower 25(OH)D levels than controls (21.0 ± 8.3 vs. 27.3 ± 9.8, p < 0.00001). Conversely, 450 psoriasis patients had lower levels of parathormone than 417 controls (38.7 ± 12.8 vs. 43.7 ± 16.5, p = 0.015). Four RCTs examined the effect of oral vitamin D supplementation on psoriasis for 173 patients and 160 patients were treated with placebo. No significant differences were found in PASI after 3, 6, and 12 months of supplementation. It is shown that 25(OH)D serum levels are significantly lower in psoriasis, but, although the granularity of RCT methodology may have influenced the pooled analysis, vitamin D supplementation did not seem to improve clinical manifestations.

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Section: General Characteristics Of Included Studies and Patientsmentioning

confidence: 99%

Section: General Characteristics Of Included Studies and Patientsmentioning

confidence: 99%

Psoriasis and Vitamin D: A Systematic Review and Meta-Analysis

Formisano,

Proietti,

Borgarelli

et al. 2023

Nutrients

View full text Add to dashboard Cite

show abstract

“…The observed diff erence was signifi cant (p=.001). 7 Several other studies have also observed a similar signifi cant decrease in serum 25-hydroxyvitamin D levels in psoriasis pa" ents. [8][9][10] However, a study conducted in Brazil found no signifi cant decrease in serum 25-hydroxyvitamin D concentra" ons in psoriasis pa" ents.…”

Section: Resultsmentioning

confidence: 68%

“…on. 7 In summary, the serum 25-hydroxyvitamin D levels in psoriasis pa! ents were signifi cantly decreased when compared to control group.…”

Section: Resultsmentioning

confidence: 97%

Serum Levels of 25-Hydroxyvitamin D in Chronic Plaque Psoriasis

Jha¹,

Basukala²,

Shrestha³

et al. 2023

Nepal J Dermatol Venereol & Leprol

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Background: Psoriasis is an immune mediated inflammatory disease that involves the innate and acquired arm of immunologic system. The regulatory role for vitamin D in immune system is suggested by presence of vitamin D receptors on activated lymphocytes and suppressive or inhibiting effect of 1,25-dihydroxyvitamin D in different autoimmune diseases. Hence, the current proposed study aims to study the 25-hydroxyvitamin D status of patients with psoriasis. Objective: The primary objective of this study was to analyze the 25-hydroxyvitamin D status of patients with chronic plaque psoriasis in comparison to healthy control subjects. Materials and Methods: A comparative cross-sectional study, including forty patients with chronic plaque psoriasis and forty age- and sex-matched control subjects, was conducted from April 2021 to December 2022, at our dermatology department. After informed consent, all patients were subjected to detailed clinical and anthropometric examination. Serum concentration of 25-hydroxyvitamin D was evaluated in chronic plaque psoriasis cases and healthy control subjects. Data was be analyzed as per standard statistical protocol. Results: The mean serum 25-hydroxyvitamin D level in psoriatic group and control group were 18.02 (±SD 9.82) ng/ml and 24.47 (±SD 6.77) ng/ml, respectively. (p=.001) Serum 25-hydroxyvitamin D was negatively correlated with Psoriatic area and severity index (PASI) score (r=-.11). However, this correlation was not significant (p=.493). Conclusion: Serum 25-hydroxyvitamin D levels were significantly lower in psoriatic patients than in control subjects.

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“…Erythematous skin plaques covered by hyperkeratotic scales are the main representations of the disease. Numerous epidemiological studies have suggested the possibility of an association between serum 25(OH)D levels and psoriasis [79][80][81][82].…”

Section: Psoriasismentioning

confidence: 99%

Impact of vitamin D on ultraviolet-induced photoaging and skin diseases

Ambagaspitiya,

Appuhamillage,

Dassanayake

2024

Exploration of Medicine

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Excessive exposure to ultraviolet (UV) radiation causes premature aging of the skin, known as photoaging. UV radiation induces DNA damage, oxidative stress, inflammatory reactions, and degradation of extracellular matrix (ECM) proteins, contributing to the aged skin phenotype. The skin synthesizes vitamin D upon UVB exposure, which plays a pivotal role in the proper function of multiple body systems. Vitamin D protects skin from photo-damage by repairing cyclobutane pyrimidine dimers, reversing oxidative stress, and reducing chronic inflammation. Moreover, various epidemiological studies have identified vitamin D deficiency as a marker for common dermatological disorders. Improvement of clinical outcomes with vitamin D supplementation further suggests its protective role against skin pathologies. This review comprehensively covers the involvement of vitamin D in combating UV-induced photoaging and various skin disorders, highlighting the significance of maintaining vitamin D adequacy for healthy skin.

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Assessment of Vitamin D Level in Patients with Psoriasis and Its Correlation with Disease Severity: A Case–Control Study

Cited by 3 publications

References 15 publications

Psoriasis and Vitamin D: A Systematic Review and Meta-Analysis

Psoriasis and Vitamin D: A Systematic Review and Meta-Analysis

Serum Levels of 25-Hydroxyvitamin D in Chronic Plaque Psoriasis

Impact of vitamin D on ultraviolet-induced photoaging and skin diseases

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