Vitamin D deficiency in pregnancy is not associated with obstructed labor, A study among Pakistani women in Karachi

Brunvand, L; Shah, Syed Sher; Bergström, Staffan; Haug, Egil

doi:10.1034/j.1600-0412.1998.770309.x

Cited by 22 publications

(10 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…While they did not examine the indications for cesarean, a small case-control study of Pakistani women looked at a specific cause (cesarean for obstructed labor from cephalopelvic disproportion) but reported no association with 25(OH)D at delivery [6]. …”

Section: Discussionmentioning

confidence: 99%

“…A Cesarean may be performed for reasons related to the mother or to the fetus including prolonged labor (dystocia), fetal distress, fetal malpresentation or a prior cesarean delivery [2]. Factors which increase risk include older maternal age, obesity, parity and ethnicity [3,4] along with a more recently defined factor—maternal nutrition [5,6,7]. …”

Section: Introductionmentioning

confidence: 99%

“…One way by which poor maternal vitamin D status might increase risk of cesarean delivery is by reducing strength of the pelvic musculature and the mother’s ability to push and deliver vaginally. However, two observational studies came to different conclusions; one reported an increased risk of cesarean for women with concentrations below 37.5 nmol/L [5] and the other no association with maternal 25(OH)D [6]. …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Maternal Vitamin D Status and Delivery by Cesarean

Scholl¹,

Chen²,

Stein

2012

Nutrients

View full text Add to dashboard Cite

We examined the association of vitamin D deficiency to risk of cesarean delivery using prospective data in a cohort of 1153 low income and minority gravidae. Circulating maternal 25-hydroxyvitamin D and intact parathyroid hormone were measured at entry to care 13.73 ± 5.6 weeks (mean ± SD). Intake of vitamin D and calcium was assessed at three time points during pregnancy. Using recent Institute of Medicine guidelines, 10.8% of the gravidae were at risk of vitamin D deficiency, and 23.8% at risk of insufficiency. Maternal 25-hydroxyvitamin D was related positively to vitamin D and calcium intakes and negatively to circulating concentrations of parathyroid hormone. Risk for cesarean delivery was increased significantly for vitamin D deficient women; there was no increased risk for gravidae at risk of insufficiency. When specific indications were examined, vitamin D deficiency was linked to a 2-fold increased risk of cesarean for prolonged labor. Results were the similar when prior guidelines for vitamin D deficiency (25(OH)D < 37.5nmol/L) and insufficiency (37.5–80 nmol/L) were utilized.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal Vitamin D Status and Delivery by Cesarean

Scholl¹,

Chen²,

Stein

2012

Nutrients

View full text Add to dashboard Cite

show abstract

“… 5 Studies of maternal vitamin D status have examined cesarean delivery, and not instrumental delivery or prolonged labor. Findings are mixed, potentially due to varying definitions of cesarean including primary, 20 , 21 cause-specific, 21 , 22 emergency or elective, 23 , 24 and/or all cause. 20 , 24 , 25 Two US studies found an inverse relationship between maternal vitamin D status and risk of primary cesarean delivery, 21 , 25 while other studies observed no associations.…”

Section: Introductionmentioning

confidence: 99%

Maternal vitamin D status, prolonged labor, cesarean delivery and instrumental delivery in an era with a low cesarean rate

et al. 2014

View full text Add to dashboard Cite

ObjectiveTo examine the association between maternal 25-hydroxyvitamin D (25(OH)D) and adverse labor and delivery outcomes.Study designWe measured serum 25(OH)D at ≤26 weeks gestation in a random subsample of vertex, singleton pregnancies in women who labored (n=2798) from the 12 site Collaborative Perinatal Project (1959–66). We used labor and delivery data to classify cases of adverse outcomes.ResultsTwenty-four percent of women were vitamin D deficient (25(OH)D <30 nmol/L) and 4.5%, 3.3%, 1.9%, and 7.5% of women had prolonged stage 1 labor, prolonged stage 2 labor, primary cesarean delivery, or indicated instrumental delivery, respectively. After adjustment for prepregnancy BMI, race, and study site, 25(OH)D concentrations were not associated with risk of prolonged stage 1 or 2, cesarean delivery, or instrumental delivery.ConclusionMaternal vitamin D status at ≤26 weeks was not associated with risk of prolonged labor or operative delivery in an era with a low cesarean rate.

show abstract

“…Two previous studies examined the association between serum vitamin D and acute cesarean delivery, but they showed conflicting results. The first study demonstrated no association between a low level (<30 nmol/l) of vitamin D and the risk of an acute cesarean delivery in a Pakistani population [32]. However, the women included in that study were characterized by malnourishment in addition to their vitamin D deficiency; moreover, the clothing customarily worn by Pakistani women may predispose them to vitamin D deficiency.…”

Section: Discussionmentioning

confidence: 88%

Seasonal Variation of Dystocia in a Large Danish Cohort

et al. 2014

View full text Add to dashboard Cite

BackgroundDystocia is one of the most frequent causes of cesarean delivery in nulliparous women. Despite this, its causes are largely unknown. Vitamin D receptor (VDR) has been found in the myometrium. Thus, it is possible that vitamin D affects the contractility of the myometrium and may be involved in the pathogenesis of dystocia. Seasonal variation of dystocia in areas with distinct seasonal variation in sunlight exposure, like Denmark, could imply that vitamin D may play a role. This study examined whether there was seasonal variation in the incidence of dystocia in a Danish population.MethodWe used information from a cohort of 34,261 nulliparous women with singleton pregnancies, spontaneous onset of labor between 37 and 42 completed gestational weeks, and vertex fetal presentation. All women gave birth between 1992 and 2010 at the Department of Obstetrics and Gynecology, Aarhus University Hospital, Skejby. Logistic regression combined with cubic spline was used to estimate the seasonal variation for each outcome after adjusting for calendar time.ResultsNo evidence for seasonal variation was found for any of the outcomes: acute cesarean delivery due to dystocia (p = 0.44); instrumental vaginal delivery due to dystocia (p = 0.69); oxytocin augmentation due to dystocia (p = 0.46); and overall dystocia (p = 0.91).ConclusionNo seasonal variation in the incidence of dystocia was observed in a large cohort of Danish women. This may reflect no association between vitamin D and dystocia, or alternatively that other factors with seasonal variation and influence on the occurrence of dystocia attenuate such an association.

show abstract

Vitamin D deficiency in pregnancy is not associated with obstructed labor, A study among Pakistani women in Karachi

Abstract: Vitamin D deficiency in pregnancy is common in Karachi, but is not associated with mechanical dystocia.

Cited by 22 publications

References 11 publications

Maternal Vitamin D Status and Delivery by Cesarean

Maternal Vitamin D Status and Delivery by Cesarean

Maternal vitamin D status, prolonged labor, cesarean delivery and instrumental delivery in an era with a low cesarean rate

Seasonal Variation of Dystocia in a Large Danish Cohort

Contact Info

Product

Resources

About