Vitamin D deficiency in patients with liver cirrhosis

Konstantakis, Christos; Tselekouni, Paraskevi; Kalafateli, Maria; Triantos, Christos

doi:10.20524/aog.2016.0037

Cited by 75 publications

(78 citation statements)

References 83 publications

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“…Hormonal differences between genders may partially explain the higher incidence of frailty in females compared to males . Some of these hormonal changes are mirrored in cirrhosis …”

Section: Pathophysiologymentioning

confidence: 99%

Frailty in advanced liver disease

Laube

Wang

Park

et al. 2018

Liver International

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Prognostication of patients with cirrhosis is complex, depending on more than just the severity of liver disease. Scores such as the model for end-stage liver disease (MELD) and Child Pugh can assist with prognostication, yet by focusing on physiological parameters they fail to completely capture the elements contributing to a patient's clinical status. Evidence is increasing to support an important role for physical functioning in patient outcomes. Frailty has been increasingly recognised in medical literature over recent years, including in hepatology where it is identified in nearly half of cirrhosis patients. It is a complex construct consisting of multisystemic physiological decline and increased vulnerability to stressors. Diagnosis is complicated by lack of a consensus definition and measurement tool for frailty in cirrhosis. Frailty heralds a poor prognosis, predicting increased morbidity and mortality both pre- and postliver transplant, independent of MELD score. It is thought to be reversible, with promising data supporting prehabilitation and lifestyle intervention programs. In the future, assessment of patients with cirrhosis is likely to incorporate a measure of frailty, however, further research is required.

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“…Hormonal differences between genders may partially explain the higher incidence of frailty in females compared to males . Some of these hormonal changes are mirrored in cirrhosis …”

Section: Pathophysiologymentioning

confidence: 99%

Frailty in advanced liver disease

Laube

Wang

Park

et al. 2018

Liver International

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“…23 Low vitamin D serum concentration significantly correlates with liver diseases, including nonalcoholic fatty liver disease 24 and hepatitis B. 25,26 Vitamin D deficiency leads to higher levels of HBV replication, which increases the risk of infection and often leads to poor outcomes in patients with liver cirrhosis. 25,26 Moreover, temperature and light have also been shown to play a role in regulating DNA methylation.…”

Section: Discussionmentioning

confidence: 99%

“…25,26 Vitamin D deficiency leads to higher levels of HBV replication, which increases the risk of infection and often leads to poor outcomes in patients with liver cirrhosis. 25,26 Moreover, temperature and light have also been shown to play a role in regulating DNA methylation. 27 Fitting for our study, it is also shown that aberrant GSTP1 promoter methylation is associated with the development of ACLF and its prognosis.…”

Section: Discussionmentioning

confidence: 99%

The Association between Meteorological Factors and the Prevalence of Acute-on-chronic Liver Failure: A Population-based Study, 2007–2016

Lin

Han

Li³

et al. 2019

Journal of Clinical and Translational Hepatology

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Background and Aims: The aim of this study was to investigate the effect(s) of meteorological factors on the prevalence of acute-on-chronic liver failure (ACLF) based on 10-years' worth of population data. Methods: We retrospectively collected ACLF case data from January 2007 to December 2016 from three major hospitals in Fuzhou City, China. Climatic data, including rainfall, mean temperature, differences in temperature (delta temperature) and mean humidity for each month were downloaded from the China Climatic Data Service Center. Following data collection, Poisson regression analysis was used to estimate the effect(s) of climatic factors on the risk of the prevalence of ACLF. Results: The population consisted of a total of 3510 cases, with a mean age of 44.7 ± 14.8 years-old and with 79.8% being male. Upon analyzing the population data, we found a growing trend and seasonal pattern of monthly counts of ACLF-related hospitalization throughout the past decade. Specifically, the primary peak of ACLF prevalence was in January and the secondary peak was in July. Poisson regression showed mean temperature (risk ratio = 0.991, 95%CI = 0.986-0.996) and mean humidity (risk ratio = 1.011, 95%CI = 1.006-1.017) to be independently correlated with the monthly cases of ACLF. The results suggest that every unit increase of mean temperature (1°C) and mean humidity (1%) are associated with 0.991-and 1.011-fold changes of ACLF cases, respectively. Rainfall and delta temperature did not appear to affect the prevalence of this disease. Conclusions: The hospitalization for ACLF peaks in January and July. Low temperature and high humidity appear to function as factors contributing to this seasonal pattern.

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“…Many clinical trials and meta-analyses have strongly linked vitamin D deficiency with liver fibrosis progression, regardless the aetiology of chronic liver disease, with unclear causality relationship whether liver morbidity, affects vitamin D synthesis or the vitamin deficiency and is the contributor in the development of liver pathology. [15] The current study tested the hypothesis of vitamin D deficiency and HBV replication in 96 HBeAg negative non-cirrhotic chronic HBV patients; in this study, the nullification of many factors that could negatively implicate the harmony of the results was maximally done, like inclusion of patients without significant fibrosis, HBeAg negative, matched age and sex, vitamin D sample withdrawal in the same month, and so on.…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin D levels in treatment-naïve chronic hepatitis B patients

Said

Agawy

Ahmed

et al. 2017

Journal of Translational Internal Medicine

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Background and Objectives: According to the demographic health survey conducted in 2015, Egypt had 10% documented prevalence of anti-HBc positive patients aged 1-59 and 1% viremic patients amongst the population in the same age group, with a domination of genotype D. Several studies claimed the possible role of vitamin D deficiency in hepatitis B virus (HBV) replication and disease progression. Patients and Methods: Serum vitamin D levels [25(OH) D3] were assessed in 96 HBeAg negative non-cirrhotic chronic HBV patients and 25 healthy subjects classified as following: Group I: 48 chronic HBV patients with persistently normal ALT levels and HBV DNA level < 2000 IU/mL for ≥ 6 months; Group II: 48 chronic HBV patients with CHB with persistently elevated ALT and HBV DNA level ≥ 2000 IU/mL for ≥ 6 months; and Group III: 25 apparently healthy subjects with normal liver enzymes and negative hepatitis viral markers were taken as the control group. Results: Vitamin D was much more deficient in group II than in group I and group III being 11.55 ± 3.97 ng/mL, 15.03 ± 3.45, 27.00 ± 6.76 ng/mL (P < 0.001), respectively, and a strong negative correlation was observed between vitamin D levels and HBV DNA levels (P = 0.043) in groups I and II. Conclusion: The current study showed high HBV DNA replication in patients with vitamin D deficiency suggesting the antimicrobial immunomodulatory role of vitamin D.

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Vitamin D deficiency in patients with liver cirrhosis

Cited by 75 publications

References 83 publications

Frailty in advanced liver disease

Frailty in advanced liver disease

The Association between Meteorological Factors and the Prevalence of Acute-on-chronic Liver Failure: A Population-based Study, 2007–2016

Serum vitamin D levels in treatment-naïve chronic hepatitis B patients

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