Serum vitamin D levels in treatment-naïve chronic hepatitis B patients

Said, Ebada; Agawy, Waleed El; Ahmed, Rehab; Hassany, Mohamed; Ahmed, Abeer; Fouad, Hanan; Baiumy, Hosam

doi:10.1515/jtim-2017-0038

Cited by 6 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies have been carried out in patients with some chronic viral infections, like HBV, HCV, and HIV. These trials have shown the following in chronically infected patients: (a) serum concentrations of vitamins A, E, D and C are decreased [72,73], (b) vitamins A, D, E and C deficiency is associated with higher levels of viral replication as well as with higher titers of pro-inflammatory cytokines, like IL-6 and TNF-α, or with illness severity in some studies carried out in different virus-associated diseases [72][73][74][75][76][77][78][79], (c) vitamins may suppress or reduce viral replication or load in different virus infections both in adults and in children [80][81][82][83][84].…”

Section: The Current Knowledge On the Possible Activity Of The Liposomentioning

confidence: 99%

Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy

Fiorino

Gallo²,

Zippi³

et al. 2020

Aging Clin Exp Res

View full text Add to dashboard Cite

Background In December 2019, a novel human-infecting coronavirus, SARS-CoV-2, had emerged. The WHO has classified the epidemic as a “public health emergency of international concern”. A dramatic situation has unfolded with thousands of deaths, occurring mainly in the aged and very ill people. Epidemiological studies suggest that immune system function is impaired in elderly individuals and these subjects often present a deficiency in fat-soluble and hydrosoluble vitamins. Methods We searched for reviews describing the characteristics of autoimmune diseases and the available therapeutic protocols for their treatment. We set them as a paradigm with the purpose to uncover common pathogenetic mechanisms between these pathological conditions and SARS-CoV-2 infection. Furthermore, we searched for studies describing the possible efficacy of vitamins A, D, E, and C in improving the immune system function. Results SARS-CoV-2 infection induces strong immune system dysfunction characterized by the development of an intense proinflammatory response in the host, and the development of a life-threatening condition defined as cytokine release syndrome (CRS). This leads to acute respiratory syndrome (ARDS), mainly in aged people. High mortality and lethality rates have been observed in elderly subjects with CoV-2-related infection. Conclusions Vitamins may shift the proinflammatory Th17-mediated immune response arising in autoimmune diseases towards a T-cell regulatory phenotype. This review discusses the possible activity of vitamins A, D, E, and C in restoring normal antiviral immune system function and the potential therapeutic role of these micronutrients as part of a therapeutic strategy against SARS-CoV-2 infection.

show abstract

Section: The Current Knowledge On the Possible Activity Of The Liposomentioning

confidence: 99%

Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy

Fiorino

Gallo²,

Zippi³

et al. 2020

Aging Clin Exp Res

View full text Add to dashboard Cite

show abstract

“…(i) A large series of clinical studies have shown that the serum concentrations of vitamins A, E and D are decreased in patients with some chronic viral infections, like HBV, HCV and HIV (60,61) , in comparison with uninfected individuals as well as in aged patients (62) . (ii) The deficiency of vitamins D, E and A is associated with higher levels of viral replication as well as with higher values of inflammatory cytokines, like IL-6 and TNF-α (63)(64)(65) .…”

Section: Defective and Dysfunctional Immune Response In Patients Withmentioning

confidence: 99%

The rationale for a multi-step therapeutic approach based on antivirals, drugs and nutrients with immunomodulatory activity in patients with coronavirus-SARS2-induced disease of different severities

et al. 2020

View full text Add to dashboard Cite

In December 2019, a novel human-infecting coronavirus, named SARS-CoV-2, has been recognized to cause a pneumonia epidemic outbreak with different degree of severity in Wuhan, Hubei Province in China. Since then this epidemic spread worldwide in Europe, and Italy also have been involved. Effective preventive and therapeutic strategies are absolutely required to block this serious public health concern. Unfortunately, few studies about SARS-CoV-2 concerning its immunopathogenesis and treatment are available. On the basis of the assumption that the SARS-CoV-2 is genetically related to SARS-CoV (about 82% of genome homology) and that its characteristics, like the modality of transmission or the type of the immune response it may stimulate, are still poor-known, a literature search was performed to identify the reports assessing these elements in patients with SARS-CoV-induced infection. Therefore, we have analyzed: 1) the structure of SARS-CoV-2 and SARS-CoV; 2) the clinical signs and symptoms and pathogenic mechanisms observed during the development of acute respiratory syndrome and the Cytokine Release Syndrome; 3) the modification of the cell microRNome and of the immune response in patients with SARS infection; 4) the possible role of some liposoluble compounds (such as vitamin A, D and E) in modulating directly or indirectly the replication ability of SARS-CoV-2 and host immune response.

show abstract

“…A decreased liver function might be one explanation for the low vitamin D levels seen in chronic liver diseases. Hepatic damages result in lower synthesis of vitamin D carrier proteins such vitamin D binding protein and albumin, as well as reduced vit D hepatic hydroxylation to 25(OH)D3 or calcidiol [ 24 ]. In a review published in 2012, Stokes et al.…”

Section: Introductionmentioning

confidence: 99%