Vitamin D deficiency in patients with aggressive periodontitis

Anbarcioglu, Emrah; Kırtıloğlu, Tuğrul; Öztürk, Ayla; Kolbakir, F.; Açıkgöz, Gökhan; Çolak, Ramis

doi:10.1111/odi.12968

Cited by 37 publications

(51 citation statements)

References 59 publications

(76 reference statements)

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“…Additionally, the presence of 25OHD2 in the predictive models is also in accordance with previous studies, where individuals with periodontitis were associated with lower levels of Vitamin D, compared to non-periodontitis [49][50][51][52][53]. Further, Vitamin D concentrations were associated with higher periodontal destruction, severe periodontitis stages and higher tooth loss [54][55][56][57][58].…”

Section: Discussionsupporting

confidence: 89%

Relationship between Blood and Standard Biochemistry Levels with Periodontitis in Parkinson’s Disease Patients: Data from the NHANES 2011–2012

Botelho

Lyra

Proença

et al. 2020

JPM

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People with Parkinson’s Disease (PD) are associated with the presence of periodontitis. We aimed to compare blood and standard biochemical surrogates of PD patients diagnosed with periodontitis with PD individuals without periodontitis. This retrospective cohort study used a sample from the National Health and Nutrition Examination Survey (NHANES) 2011–2012 that underwent periodontal diagnosis (n = 3669). PD participants were identified through specific PD reported medications. Periodontitis was defined according to the 2012 case definition, using periodontal examination data provided. Then, we compared blood levels and standard chemical laboratory profiles of PD patients according to the presence of periodontitis. Multivariable regression was used to explore this dataset and identify relevant variables towards the presence of periodontitis. According to the medication report, 37 participants were eligible, 29 were secure and 8 were unsecure PD medications regimens. Overall, PD cases with periodontitis presented increased levels of White Blood Cells (WBC) (p = 0.002), Basophils (p = 0.045) and Segmented neutrophils (p = 0.009), and also, lower levels of Total Bilirubin (p = 0.018). In the PD secure medication group, a significant difference was found for WBC (p = 0.002) and Segmented neutrophils (p = 0.002) for the periodontitis group. Further, WBC might be a discriminating factor towards periodontitis in the global sample. In the secure PD medication, we found gender, segmented neutrophils and Vitamin D2 to be potential discriminative variables towards periodontitis. Thus, periodontitis showed association with leukocyte levels alterations in PD patients, and therefore with potential systemic changes and predictive value. Furthermore, Vitamin D2 and gender showed to be associated with periodontitis in with secure medication for PD. Future studies should assess in more detail the potential systemic repercussion of the presence of periodontitis in PD patients.

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Section: Discussionsupporting

confidence: 89%

Relationship between Blood and Standard Biochemistry Levels with Periodontitis in Parkinson’s Disease Patients: Data from the NHANES 2011–2012

Botelho

Lyra

Proença

et al. 2020

JPM

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“…Vitamin D is increasingly considered to be beneficial for periodontal health in the recent studies including our own study, however, vitamin D seemed harmful to the periodontal health in the present study. Actually, it was revealed by the co‐culture model of human peripheral blood mononuclear cells with hGFs or hPDLCs that although osteoclastogenesis could be induced by hGFs and hPDLCs, the induced osteoclast‐like cells were not functional and extra activation was needed .…”

Section: Discussioncontrasting

confidence: 68%

Preliminary investigation on the molecular mechanisms underlying the correlation between VDR‐FokI genotype and periodontitis

Liu

Han

Hou

et al. 2020

Journal of Periodontology

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Background The only polymorphism that could change the protein structure in vitamin D receptor (VDR) is the FokI polymorphism (rs2228570). The FF genotype has the strongest transcriptional activity of VDR and is correlated with higher susceptibility to periodontitis. To reveal the possible molecular mechanisms for the correlation preliminarily, the influence of VDR‐FokI genotype on the expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL) in human gingival fibroblasts (hGFs) and human periodontal ligament cells (hPDLCs) was investigated in this study. Methods hGFs and hPDLCs from 15 donors (five FF, seven Ff, and three ff) were treated with 1,25OH2D3, with or without the specific knockdown of VDR using siRNA. The mRNA and protein expression of OPG and RANKL were detected using real‐time PCR and enzyme‐linked immunosorbent assay, respectively. Results Both in hGFs and hPDLCs, 1,25OH2D3 could significantly induce the mRNA and protein expression of RANKL, and FF genotype had significantly higher induction than the other genotypes, however, neither 1,25OH2D3 nor VDR‐FokI had significant influence on the OPG expression. As a result, the RANKL/OPG ratio was significantly elevated under 1,25OH2D3 stimulation and FF genotype had the most remarkable elevation. When VDR was knocked down, all the differences among the three genotypes disappeared. Conclusion The strongest transcriptional activity of FF genotype might contribute to the strongest enhancement of RANKL expression and RANKL/OPG ratio in hGFs and hPDLCs stimulated by 1,25OH2D3, which might help to reveal the mechanisms of the correlation between FF genotype and susceptibility to periodontitis.

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“…Overall, the included case-control studies were from ten different countries, across Asia, Europe and America ( Table 1 ), with a total of 10,597 participants included in this review. Two articles [ 28 , 56 ] reported 91 aggressive periodontitis cases—one assessed the circulating 25(OH)D levels [ 28 ], and the other assessed salivary levels [ 56 ]. Quantitative analysis included a total of 10,506 subjects (subcategorised as 9718 periodontal healthy patients and 788 patients with chronic periodontitis) from 13 studies, of which three [ 33 , 57 , 58 ] assessed 25(OH)D levels through salivary samples, nine through serum levels [ 28 , 29 , 30 , 31 , 32 , 36 , 59 , 60 , 61 ], and one assessed both methods [ 62 ].…”

Section: Resultsmentioning

confidence: 99%

“…The nutritional consequences of vitamin D levels on periodontal health represent a matter of interest [ 22 , 23 , 24 , 25 , 26 , 27 ]. Over decades, lower vitamin D levels have been associated with higher periodontal destruction and severe periodontitis stages [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. Others supported the idea that patients with higher levels of vitamin D were related to less bleeding on probing (BoP) comparing to patients with lower levels [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and Periodontitis: A Systematic Review and Meta-Analysis

Machado

Lobo

Proença³

et al. 2020

Nutrients

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To explore the vitamin D levels of periodontitis patients in comparison with periodontally healthy ones, and to assess the influence of vitamin D supplementation as an adjunctive during nonsurgical periodontal treatment (NSPT). Five databases (Pubmed, Embase, Scholar, Web of Sciences, and Cochrane Library) were searched until May 2020. Mean difference (MD) meta-analysis with corresponding 95% confidence interval (95% CI) and sensitivity tests via meta-regression were used. We followed Strength of Recommendation Taxonomy (SORT) to appraise the strength and quality of the evidence. Sixteen articles were included, fourteen case-control and two intervention studies, all reporting 25-hydroxyvitamin D (25(OH)D) levels. Compared with the healthy controls, the circulating 25(OH)D levels were significantly lower in chronic periodontitis patients (pooled MD = −6.80, 95% CI: −10.59 to −3.02). Subgroup analysis revealed differences among 25(OH)D measurements, with liquid chromatography-mass spectrometry being the most homogeneous method (pooled MD = −2.05, 95% CI: −3.40 to −0.71). Salivary levels of 25(OH)D showed no differences between groups. Due to the low number of studies, conclusions on aggressive periodontitis and in the effect of vitamin D supplementation after NSPT were not possible to ascribe. Compared with healthy controls, 25(OH)D serum levels are significantly lower in chronic periodontitis patients, with an overall SORT A recommendation. Future studies are needed to clarify the effect of vitamin D supplementation and the biological mechanisms linking vitamin D to the periodontium.

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Vitamin D deficiency in patients with aggressive periodontitis

Abstract: Our results suggest that vitamin D deficiency may be a potential risk factor for AgP. Given the high prevalence of vitamin D deficiency in AgP patients, routine screening for vitamin D status may be advisable in these subjects.

Cited by 37 publications

References 59 publications

Relationship between Blood and Standard Biochemistry Levels with Periodontitis in Parkinson’s Disease Patients: Data from the NHANES 2011–2012

Relationship between Blood and Standard Biochemistry Levels with Periodontitis in Parkinson’s Disease Patients: Data from the NHANES 2011–2012

Preliminary investigation on the molecular mechanisms underlying the correlation between VDR‐FokI genotype and periodontitis

Vitamin D and Periodontitis: A Systematic Review and Meta-Analysis

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