Vitamin D deficiency in Iranian mothers and their neonates: a pilot study

Abstract

We conducted a pilot study to assess the prevalence of hypovitaminosis D among Iranian women and their newborns. Blood samples were taken from 50 mothers (age 16-40 yr) and their neonates at term delivery in the largest Tehran hospital. The results showed that 80% of the women had 25-hydroxyvitami n D (25-OHD) concentrations of less than 25 nmol/l. Mean maternal plasma calcium and phosphatase alkaline concentrations were in the normal range. The mean maternal serum immunoreactive parathyroid hormone concentration of women with hypovitaminosis D (i.e., 25-OHD levels <25 nmol/l) was above normal range and signi cantly different from that of women without hypovitaminosis D. Conclusion:The mean cord serum 25-OHD concentration was very low (4.94 § 9.4 nmol/l) and that of infants of mother with hypovitaminosis D were almost undetectable (1.2 § 1.2 nmol/l).

Incidence of maternal vitamin D deficiency in a region of Ankara, Turkey: a preliminary study

“…The incidence of maternal vitamin D deficiency was reported to be between 18% and : chi-square test (P < 0.05), data are given as median (minimum-maximum), BMI: body mass index. 84% in studies from different countries that accepted a level of 25(OH)D of <10 ng/mL as vitamin D deficiency (16)(17)(18)(19). In the study by Andiran et al performed in 2002 in Ankara, the rate of vitamin D deficiency (<10 ng/ mL) was found to be 46% and 80% in mothers and their babies, respectively (20).…”

Global vitamin D status and determinants of hypovitaminosis D

“…Neonatal size or bone mass may be affected by maternal vitamin D status [87]. No effect of maternal vitamin D levels on neonatal birth weight was detected in a sample of 50 mothers-neonates from Iran after adjusting for maternal height, age, and parity [112]. Conversely, in a larger sample of 449 women and their newborns from Tehran, neonates of mothers with adequate calcium and vitamin D intake were 0.9 cm taller and had a better Apgar at birth [119].…”

“…Studies from Saudi Arabia, Kuwait, United Arab Emirates, and Iran reveal that 10-60% of mothers and 40-80% of their neonates had undetectable low vitamin D levels (0-25 nmol/L) at delivery [112][113][114][115]. Neonatal outcomes were not detailed in most studies.…”

A study of prevalence of Vitamin D deficiency among pregnant women and its impact on feto maternal outcome

“…[1][2][3][4][5] Vitamin D deficiency is common in darkskinned persons, veiled populations living at various latitudes and inadequate vitamin D intake in women of 2,[5][6][7][8][9][10][11][12][13] The interaction of 1, 25(OH) 2D with nuclear vitamin D receptors influences gene transcription. Nuclear receptors for 1, 25(OH) 2D are present in a range of tissues including bone, intestine, kidney, lung, muscle and skin.…”