Vitamin D deficiency in elderly: Risk factors and drugs impact on vitamin D status

Kweder, Hasan; Eidi, Housam

doi:10.4103/ajm.ajm_20_18

Cited by 64 publications

(56 citation statements)

References 76 publications

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“…The reasons are that compared with young adults, the skin’s capacity to produce vitamin D decreases by 75% at 70 years 29 , 31 . In addition, the elderly have a tendency to wear closed clothing for fear of flu, thus causing minimal exposure to ultraviolet B rays 9 . Their food intake decreases because of a decrease in chewing ability and financial conditions 30 .…”

Section: Discussionmentioning

confidence: 99%

“…The impaired eating ability in the elderly may also contribute to low concentrations of vitamin D. Therefore, vitamin D deficiency is often associated with various geriatric syndromes. Low concentrations of vitamin D affects the activity of endocrine hormones as in sufferers of diabetes mellitus type 2 (T2DM) and cardiovascular functions, such as coronary artery disease, heart failure, stroke, and hypertension 9 . A recent meta-analysis in individuals with vitamin D deficiency showed oral vitamin D3 reduces both systolic BP (SBP) and diastolic BP (DBP) in individuals with hypertension and decreases SBP in individuals above 50 years.…”

Section: Introductionmentioning

confidence: 99%

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Effects of vitamin D supplementation on 25(OH)D concentrations and blood pressure in the elderly: a systematic review and meta-analysis

et al. 2020

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Background: Hypertension and vitamin D deficiency are prevalent among the elderly. This study evaluated the effects of vitamin D supplementation on changes in serum 25-hydroxyvitamin D (25(OH)D) concentrations and blood pressure (BP) in the elderly (age > 60 years). Methods: Randomized controlled trials from electronic databases on the elderly taking oral vitamin D, until the end of March 2019, were selected. Two reviewers independently screened the literature on the basis of specific inclusion criteria. The primary outcomes were serum 25(OH)D level, systolic BP (SBP), and diastolic BP (DBP) changes. Results: Our analysis revealed significant differences in serum 25(OH)D concentrations changes between the vitamin D and control groups (mean difference [MD] = 13.84; 95% confidence interval [CI] = 10.21–17.47; P < 0.000). There were no significant differences in SBP and DBP changes between the vitamin D and control groups. Subgroup analysis revealed significant differences in SBP changes between the hypertensive and vitamin D-deficient subgroups (MD = –4.01; 95% CI = –7.45 to –0.57; P = 0.02 and MD = –1.91; 95% CI = –3.48 to –0.34; P = 0.02, respectively), and DBP changes only in the hypertensive subgroup (MD = –2.22; 95% CI = –4.1 to –0.34; P = 0.02). Conclusions: Vitamin D supplementation significantly increases 25(OH)D concentrations and seems beneficial in lowering BP, specifically in the elderly with elevated BP and vitamin D deficiency.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of vitamin D supplementation on 25(OH)D concentrations and blood pressure in the elderly: a systematic review and meta-analysis

et al. 2020

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“…Female gender is associated with lower vitamin D levels (14.5 ± 10.9 vs. 15.9 ± 9.5, p = 0.007) and independently associated with severe vitamin D deficiency (41.9% vs. 30.4%, p < 0.001; adjusted odds ratio (OR) (95% confidence interval (CI)) = 1.42 (1.08-1.87), p = 0.01). Yet note that a French and Canadian study reported elderly males suffered from a serious vitamin D deficiency as compared to elderly females 56 .…”

Section: Figure 1 Ccfr Is Significantly Higher In Countries With Higmentioning

confidence: 98%

“…To address this question, we compared the prevalence of severe vitamin D deficiency (25-hydroxyvitamin D serum concentration below 12 ng/ ml (30 nmol/l)) and intake levels in different countries 27,28,29,30,31,32,33,34 , with COVID-19 case growth rates and confirmed case fatality rates (cCFR).…”

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confidence: 99%

Double COVID-19 Confirmed Case Fatality Rate in Countries with High Elderly Female Vitamin D Deficiency Prevalence

Bäcker

Mageswaran

2020

SSRN Journal

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A number of clues point to a possible role of vitamin D in fighting COVID-19: a reduction in case growth speed with solar zenith angle, higher fatality rate in black people, lower fatality rate in populations that spend more time outdoors. Yet a direct demonstration that vitamin D deficiency is associated with COVID-19 fatalities has remained elusive. We show here in a comparison of 32 countries that countries with high prevalence of vitamin D deficiency among elderly females show a confirmed case fatality rate twice as high as those with low prevalence. We then show that this effect cannot be explained by differences in life expectancy between countries. A mechanistic role for vitamin D in the severity of COVID-19 is proposed. One Sentence Summary: Vitamin D deficiency among elderly females is associated with countrywide COVID-19 confirmed case fatality rates up to twice as high as those of countries with low vitamin D deficiency prevalence.

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“…La nivelul CPA, 1,25 (OH) 2D inhibă exprimarea antigenelor complexului major de histocompatibilitate clasa II și a moleculelor co-stimulatoare și previne diferențierea și maturarea CD, precum și activarea și supraviețuirea acestora, conducând la scăderea antigenului și activarea celulelor T. Mai mult, 1,25 (OH) 2D modulează de asemenea expresia citokinelor derivate de la DC prin inhibarea producției de interleukină (IL) -12 și IL-23 (citokine majore care determină diferențierea Th1 și diferențierea celulelor T helper (Th17)) și îmbunătățirea eliberării IL-10. 14%, rezultate asemănătoare fiind raportate în studiile de specialitate (Kweder H, Eidi H, 2018). Pacienții vârstnici cu deficit sau insuficiență de vitamina D (95%), au avut o prevalență semnificativ mai mare a titrurilor de anticorpi anti tiroid peroxidază (media ATPO), comparativ cu pacienții vârstnici cu niveluri normale ale vitaminei D (5%).…”

Section: Discuțiiunclassified

Corelații între vitamina D și obezitate, în tiroidita cronică autoimună

Cînpeanu¹,

Tarcea²,

Voidăzan³

et al. 2019

JMB

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Aim: Assessing vitamin D status in patients with chronic autoimmune thyroiditis, and establishing correlations between obesity, vitamin D levels and anti-thyroid-peroxidase antibody titers. Methods. A total of 109 patients were prospectively studied; they were registered at the Endocrinology Cabinet of the Municipal Hospital "Dr. Gheorghe Marinescu" form Târnăveni, and diagnosed for the first time with chronic autoimmune thyroiditis, with normal thyroid status, with or without obesity. Results. Our study enrolled patients ranging from 18 to 87 years of age (one third of them under 50 years old), and 91 of whom were women (83.48%); 66.97% were overweight or obese. Titer of anti-thyroidperoxidase antibodies showed significantly higher levels in patients with low vitamin D. In the studied group, in 50.4% of the people the vitamin D level was inadequate and the vitamin D deficiency appears in 38.2% of the investigated patients. Anti-thyroid peroxidase antibody titers were higher in older patients. Also, as patients had a BMI closer to obesity, the deficiency of vitamin D was increasing. Conclusions. Based on our observations, vitamin D status correlates negatively with anti-thyroid peroxidase antibody levels, body mass index and age of patients. Rezumat: Scop studiul a fost de a evalua vitamina D la pacienții cu tiroidită cronică autoimună și stabilirea corelațiilor dintre obezitate, nivelul de vitamina D și titluri de anticorpi anti-tiroid-peroxidază. Metode. Au fost studiați în mod prospectiv 109 pacienți diagnosticați pentru prima dată la Cabinetul de Endocrinologie al Spitalului Municipal "Dr. Gheorghe Marinescu" din Târnăveni cu tiroidită cronică autoimună, cu statut tiroidian normal, cu sau fără obezitate. Rezultate. Studiul a înscris pacienți cu vârste cuprinse între 18 și 87 de ani (o treime dintre ei sub 50 de ani), iar 91 dintre ei erau femei (83,48%); 66,97% erau supraponderali sau obezi. Titrul anticorpilor antitiroid-peroxidază a arătat niveluri semnificativ mai mari la pacienții cu vitamina D. scăzută. În grupul studiat, la 50,4% dintre persoane nivelul de vitamina D a fost inadecvat, iar insuficiența de vitamina D apare la 38,2% dintre pacienții investigați. Titrurile de anticorpi anti-tiroidă peroxidază au fost mai mari la pacienții mai în vârstă. De asemenea, pe măsură ce pacienții aveau un IMC mai aproape de obezitate, deficiența de vitamina D era mai mare. Concluzii. Pe baza observațiilor noastre, statutul de vitamină D se corelează negativ cu nivelul anticorpilor anti tiroid peroxidază, indicele de masa corporala și vârsta pacienților.

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Vitamin D deficiency in elderly: Risk factors and drugs impact on vitamin D status

Cited by 64 publications

References 76 publications

Effects of vitamin D supplementation on 25(OH)D concentrations and blood pressure in the elderly: a systematic review and meta-analysis

Effects of vitamin D supplementation on 25(OH)D concentrations and blood pressure in the elderly: a systematic review and meta-analysis

Double COVID-19 Confirmed Case Fatality Rate in Countries with High Elderly Female Vitamin D Deficiency Prevalence

Corelații între vitamina D și obezitate, în tiroidita cronică autoimună

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