Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity

Reyman, Marta; Stuart, A. A. Verrijn; Summeren, Marieke J. H. van; Rakhshandehroo, Maryam; Nuboer, Roos; Boer, Folkert K. de; Ham, Henk-Jan van den; Kalkhoven, Eric; Prakken, Berent J.; Bateman, Scott

doi:10.1038/ijo.2013.75

Cited by 60 publications

(54 citation statements)

References 37 publications

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“…In the logistic regression analysis, glycemic control was not affected by 25(OH) D levels after adjusting for related variables, such as age, sex, BMI, DM duration, baseline HbA1c, lifestyle, (alcohol, smoking, and regular exercise), HOMA-IR, and outdoor physical activity (Table 5). [12] and insulin action [13,14], as well as components of inflammation [34,35] and all of these may have an influence on insulin resistance (IR) and development of T2DM. Vitamin D may modulate the local pancreatic islet renin-angiotensin system (RAS) whilst improving islet beta cell secretory function and prevents or can correct induction of RAS component production under conditions of metabolic stress in vitro studies [36,37].…”

Section: Resultsmentioning

confidence: 99%

A prospective randomized controlled trial of the effects of vitamin D supplementation on long-term glycemic control in type 2 diabetes mellitus of Korea

Ryu

Lee

et al. 2014

Endocr J

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Section: Resultsmentioning

confidence: 99%

A prospective randomized controlled trial of the effects of vitamin D supplementation on long-term glycemic control in type 2 diabetes mellitus of Korea

Ryu

Lee

et al. 2014

Endocr J

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“…Our findings are of importance because little it is known about the relationship between 25(OH)D levels and immune markers of inflammation, especially in the elderly. The few published data coming from observational studies (Amer and Qayyum 2012;Reyman et al 2013;Laird et al 2014;Ngo et al 2010;Peterson and Heffernan 2008) support a primary anti-inflammatory role of vitamin D. In a very recent observational investigation conducted in 957 older Irish adults (>60 years of age), Laird et al (Laird et al 2014) showed a significant association between low vitamin D status (25OH-D <25 nmol/L) and markers of inflammation including IL-6, TNF-α, IL-10, hsCRP, and the ratio of IL-6 to IL-10.…”

Section: Discussionmentioning

confidence: 99%

Relationship between vitamin D and inflammatory markers in older individuals

Vita

Lauretani

Bauer

et al. 2014

AGE

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In older persons, vitamin D insufficiency and a subclinical chronic inflammatory status frequently coexist. Vitamin D has immune-modulatory and in vitro anti-inflammatory properties. However, there is inconclusive evidence about the anti-inflammatory role of vitamin D in older subjects. Thus, we investigated the hypothesis of an inverse relationship between 25-hydroxyvitamin D (25(OH)D) and inflammatory markers in a population-based study of older individuals. After excluding participants with high-sensitivity C-reactive protein (hsCRP)≥10 mg/dl and those who were on chronic anti-inflammatory treatment, we evaluated 867 older adults ≥65 years from the InCHIANTI Study. Participants had complete data on serum concentrations of 25(OH)D, hsCRP, tumor necrosis factor (TNF)-α, soluble TNF-α receptors 1 and 2, interleukin (IL)-1β, IL-1 receptor antagonist, IL-10, IL-18, IL-6, and soluble IL-6 receptors (sIL6r and sgp130). Two general linear models were fit (model 1-adjusted for age, sex, and parathyroid hormone (PTH); model 2-including covariates of model 1 plus dietary and smoking habits, physical activity, ADL disability, season, osteoporosis, depressive status, and comorbidities). The mean age was 75.1±17.1 years±SD. In model 1, AGE (2014) log(25OH-D) was significantly and inversely associated with log(IL-6) (β±SE=−0.11±0.03, p=<0.0001) and log (hsCRP) (β±SE=−0.04±0.02, p=0.04) and positively associated with log(sIL6r) (β±SE=0.11±0.04, p=0.003) but not with other inflammatory markers. In model 2, log (25OH-D) remained negatively associated with log (IL-6) (β±SE=−0.10±0.03, p=0.0001) and positively associated with log(sIL6r) (β±SE=0.11± 0.03, p = 0.004) but not with log(hsCRP) (β ±SE= −0.01±0.03, p=0.07). 25(OH)D is independently and inversely associated with IL-6 and positively with sIL6r, suggesting a potential anti-inflammatory role for vitamin D in older individuals.

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“…One of the most discussed in literature possible contributors of the obesity itself and its complications remains hypovitaminosis D. Many studies confirmed a high prevalence of vitamin D deficiency in obese patients, since both conditions are often associated. Approximately 60% of children and adolescents are overweight or obese in comparison to 20% of those who are non-obese subjects [1,2,3,4]. However, an inverse correlation between body mass index (BMI), fat tissue content and vitamin D levels had been proved in many studies, and a recently published metaanalysis of 21 adult cohorts (up to 42,024 participants) revealed that higher a BMI leads to a lower vitamin D level.…”

Section: Introductionmentioning

confidence: 99%

“…The main causes of this increase in cardiometabolic risk are a decrease in insulin sensitivity and compensatory hyperinsulinemia [1,2,3,4]. A strong association between insulin resistance and an excess of fat tissue has been recognized for decades, but some details of its origin remain unclear to date.…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies had shown, that hypovitaminosis D might be not only one of the many obesity complications, but may be also a potential trigger factor of the consecutive metabolic disturbances. It had been shown, that low vitamin D level may be involved in the activation of a pro-inflammatory, pro-diabetic and atherogenic pathways in obese children [2].…”

Section: Introductionmentioning

confidence: 99%

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The potential impact of the hypovitaminosis D on metabolic complications in obese adolescents – Preliminary results

Wójcik

Januś

Kalicka-Kasperczyk

et al. 2017

Ann Agric Environ Med.

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Introduction and objective. Vitamin D deficiency is common in obesity; however, its contribution in the development of metabolic complications remains uncertain. The aim of the study was to examine the relationships between vitamin D status and metabolic complications. Materials and method. The results of blood pressure measurements, biochemical tests and ultrasound of the liver were compared in both groups. The study was conducted at the Children's University Hospital in Krakow, Poland. 30 obese adolescents (mean 13.23y.o.); 18 with 25OHD levels <20ng/mL, 12 with 25OHD>20 ng/mL. Results. The vitamin D deficient group presented with significantly higher values of the diastolic blood pressure (125.9vs.115mmHg), uric acid level (384.7vs.301.5umol/L) and lower phosphorus level (1.4vs.1.65mmol/L), higher prevalence of arterial hypertension (44vs.8.3%), and liver steatosis (25vs.8.3%); lower, but not significantly, levels of fibroblast growth factor 23 and fibroblast growth factor 19. Conclusions. Hypovitaminosis D in obese adolescents is associated with higher prevalence of arterial hypertension, liver steatosis, elevated serum uric acid and low phosphorus levels. The potential contribution of the fibroblast growth factor 23 and fibroblast growth factor 19 in these complications development needs further investigation.

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Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity

Cited by 60 publications

References 37 publications

A prospective randomized controlled trial of the effects of vitamin D supplementation on long-term glycemic control in type 2 diabetes mellitus of Korea

A prospective randomized controlled trial of the effects of vitamin D supplementation on long-term glycemic control in type 2 diabetes mellitus of Korea

Relationship between vitamin D and inflammatory markers in older individuals

The potential impact of the hypovitaminosis D on metabolic complications in obese adolescents – Preliminary results

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