Vitamin D deficiency and risk of Helicobacter pylori infection in older adults: a cross-sectional study

Sürmeli, Deniz Mut; Surmeli, Zeki Gokhan; Bahşi, Remzi; Turgut, Tuğba; Öztorun, Hande Selvi; Atmış, Volkan; Aras, Sevgi

doi:10.1007/s40520-018-1039-1

Cited by 24 publications

(39 citation statements)

References 35 publications

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“…VitD deficiency has been reported to increase the risk of Hp infection. 4 The detection of 25-hydroxyvitamin D 3 (25-(OH)D 3 ) can reflect the VitD levels in the human body. Interleukin-1β (IL-1β) has been reported to be related to Hp infection.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis

Zhang

Guo

et al. 2020

Pak J Med Sci

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Objective: To study whether the levels of 25-hydroxyvitamin D3 (25-(OH)D3) and Interleukin-1β (IL-1β) are correlated to the eradication and recurrence of helicobacter pylori (Hp) in paediatric patients with Hp infection-related gastritis. Methods: A total of 142 paediatric patients with Hp infection-related gastritis from November 2017 to March 2018 in Baoding Children’s Hospital were selected as study subjectswere selected as study subjects and were followed up for one year. Paediatric patients were grouped and analyzed according to the effect of follow-up treatment and recurrence. Results: The levels of 25-(OH) D3 in the non-eradication group were lower than those in the eradication group and the control group (F=27.087, P<0.05); the levels of IL-1β were higher than those in the eradication group and the control group (F=16.610, P<0.05). Recurrence during follow-up visits: The levels of 25-(OH) D3 in the recurrence group were lower than those in the non-recurrence group and the control group (F=33.837, P<0.05); the levels of IL-1β in the recurrence group were higher than those in the non-recurrence group and the control group (F=7.896, P<0.05). Correlation analysis showed the levels of 25-(OH) D3 and IL-1β in the eradication group and the non-eradication group were negatively correlated (r=-0.232, P<0.05); the levels of 25-(OH) D3 and IL-1β in the recurrence group and the non-recurrence group were negatively correlated (r=-0.225, P<0.05). Conclusion: Relatively high levels of IL-1β may be correlated to the difficulty in eradicating the Hp infection in paediatric patients. Relatively low levels of 25-(OH) D3 may be correlated to the difficulty in eradicating the Hp infection and recurrence in paediatric patients. doi: https://doi.org/10.12669/pjms.36.6.2292 How to cite this:Zhang Y, Bi B, Guo X, Zhang S. Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis. Pak J Med Sci. 2020;36(6):---------. doi: https://doi.org/10.12669/pjms.36.6.2292 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Introductionmentioning

confidence: 99%

Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis

Zhang

Guo

et al. 2020

Pak J Med Sci

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“…Vitamin D regulates the calcium and phosphorus metabolism needed for bone formation, and the influence of vitamin D on H. pylori infection and eradication rates has recently been widely investigated. Several clinical studies have illustrated that vitamin D analogs may have anti‐ H. pylori antimicrobial effects . Cytological research has also found that vitamin D 3 decomposition product 1 (VDP1) can lyse H. pylori bacterial cells by inducing the collapse of the cell membrane …”

Section: Introductionmentioning

confidence: 99%

“…Several clinical studies have illustrated that vitamin D analogs may have anti-H. pylori antimicrobial effects. [4][5][6][7][8][9][10] Cytological research has also found that vitamin D 3 decomposition product 1 (VDP1) can lyse H. pylori bacterial cells by inducing the collapse of the cell membrane. 11,12 However, the correlation between vitamin D levels and H. pylori has not been fully illustrated, and studies on the impact of serum vitamin D levels on H. pylori eradication were mostly of small sample sizes.…”

Section: Introductionmentioning

confidence: 99%

“…Another study found that the alkyl of indene, a product of vitamin D decomposition, had the key conformation of interaction with the di-14:0 DMPE in the lipid membrane component of H. pylori, which eventually induced lysis, and the absence of alkyl led to the loss of a bactericidal effect on H. pylori 12. Several clinical studies have illustrated that vitamin D analogs may have anti-H. pylori antimicrobial effects [4][5][6][7][8][9][10]. Some studies have also found that serum vitamin D levels may have an impact on H. pylori eradication [7][8][9].…”

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confidence: 99%

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Influence of serum vitamin D level on Helicobacter pylori eradication: A multi‐center, observational, prospective and cohort study

Han

Yuan

et al. 2019

J of Digest Diseases

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Objectives This study was designed to test whether serum vitamin D levels affected Helicobacter pylori (H. pylori) infection and eradication rates. Methods A multicenter observational prospective cohort study was conducted. A total of 496 H. pylori− positive (H. pylori+) and 257 H. pylori‐negative (H. pylori−) patients were enrolled from four hospitals in China. Baseline serum vitamin D levels were measured and a 13C‐urea breath test (UBT) was performed for all the participants. The H. pylori+ patients were divided into two subgroups based on their serum vitamin D levels (<10 or ≥10 ng/mL). A second 13C‐UBT was performed between 4 and 8 weeks after 14‐day bismuth‐containing quadruple eradication therapies. Factors potentially affecting H. pylori eradication were determined using a questionnaire survey. Results Serum vitamin D levels were significantly lower in the H. pylori+ group than in the H. pylori− group ([17.0 ± 6.9] ng/mL vs [19.2 ± 8.0] ng/mL, P = 0.000). H. pylori eradication rate significantly differed between patients with serum vitamin D levels of <10 ng/mL and ≥10 ng/mL (71.7% vs 87.3%, P = 0.005). A multivariate analysis showed that having serum vitamin D level ≥10 ng/mL was an independent risk factor for a successful H. pylori eradication (odds ratio 0.381, 95% confidence interval 0.183‐0.791, P = 0.010). Conclusions Serum vitamin D level may affect H. pylori infection and its eradication. Randomized controlled trials are needed to find out whether vitamin D supplements may increase the H. pylori eradication rate.

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“…Our search identified 182 related references, of which 10 papers met our inclusion criteria . The flowchart describing the process of study selection is shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

Effect of vitamin D on Helicobacter pylori infection and eradication: A meta‐analysis

Yang

et al. 2019

Helicobacter

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Background Various studies reported the relationship between Helicobacter pylori (H pylori) and vitamin D, but there is some controversy around that. This study aimed to conduct a meta‐analysis to clarify the relationship between vitamin D and H pylori infection, and vitamin D and H pylori eradication. Methods Articles published until June 1, 2019, in the PubMed, MEDLINE, and EMBASE databases with English‐language medical studies were searched. According to the inclusion criteria, relevant statistical data were extracted to Microsoft Excel and analyzed by STATA15.1. Results Ten articles were finally included. It was demonstrated that average 25(OH)D level in H pylori‐positive patients was lower than H pylori‐negative (SMD = −0.53 ng/mL, 95% CI = (−0.91, −0.16 ng/mL)). For H pylori eradication individuals, the result showed that average 25(OH)D level in H pylori successful eradication individuals was higher than unsuccessful (SMD = 1.31 ng/mL, 95% CI = [0.60, 2.02 ng/mL]). In addition, individuals with vitamin D deficiency had lower H pylori eradicate rate (OR = 0.09, 95% CI = [0.02, 0.41]). Sensitivity analysis showed that the meta‐analysis results were stable and reliable. Conclusions Vitamin D was a protective factor to H pylori infection. Moreover, vitamin D can improve the success rate of H pylori eradication.

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Vitamin D deficiency and risk of Helicobacter pylori infection in older adults: a cross-sectional study

Cited by 24 publications

References 35 publications

Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis

Analysis of Eradication, Recurrence and Levels of 25-hydroxyvitamin D3 and Interleukin-1β in paediatric patients with Helicobacter Pylori Infection-related Gastritis

Influence of serum vitamin D level on Helicobacter pylori eradication: A multi‐center, observational, prospective and cohort study

Effect of vitamin D on Helicobacter pylori infection and eradication: A meta‐analysis

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