Vitamin D deficiency and peripheral diabetic neuropathy

Skalli, S.; Müller, Marie; Pradines, Stéphane; Halimi, Serge; Wion-Barbot, N.

doi:10.1016/j.ejim.2011.11.008

Cited by 46 publications

(34 citation statements)

References 9 publications

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“…A D-vitamin-szint szignifi kánsan alacsonyabb volt a neuropathiában szenvedő diabeteses csoportban a neuropathiában nem szenvedő cukorbeteghez képest (24,6±11,9 vs. 34,74±17,6 nmol/l, p<0,001). Mindamellett a D-vitamin-hiány elő-fordulása [25(OH)D-vitamin-szint <20 ng/ml] szignifi kánsan magasabbnak bizonyult a neuropathiás betegcsoportban, összehasonlítva a neuropathiában nem szenvedő diabetesesekkel ˙(95% vs. 79%, p<0,05) [25].…”

Section: A D-vitamin Szerepe a Neuropathia Kialakulásábanunclassified

Vitamin D and neuropathy

et al. 2013

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A D-vitamin csontanyagcserén túlmutató hatása a tudományos fi gyelem középpontjába került az utóbbi években. A cukorbetegséggel és annak szövődményeivel kapcsolatos vizsgálatok pedig kiemelt népegészségügyi jelentőség-gel bírnak. Egyre több adat támasztja alá a D-vitamin-hiány és a cukorbetegség kapcsolatát, a diabeteses neuropathia és a D-vitamin kapcsolatáról azonban eddig kevés és ellentmondó adat áll rendelkezésre. A többségében 2-es típusú cukorbetegek körében végzett vizsgálatok alátámasztják a D-vitamin-hiány és a neuropathia előfordulása, illetve a neuropathia okozta tünetek súlyossága közötti kapcsolatot. A legújabb tanulmányok a talpi fekélyek kialakulásában is felvetik a D-vitamin-hiány kóroki szerepét. Orv. Hetil., 2013, 154(51), 2012-2015. Kulcsszavak: D-vitamin, diabetes mellitus, neuropathia Vitamin D and neuropathyDiabetes is a widespread disease and, therefore, studies dealing with diabetes and its complications are very important for public health. Numerous reports link vitamin D defi ciency to the increased risk of diabetes mellitus and complications such as neuropathy. However, there are limited and confl icting data available on vitamin D defi ciency in patients with diabetic peripheral neuropathy. Studies in type 2 diabetics confi rmed the relationship between vitamin D deficiency and incidence of neuropathy. Recent reports suggest a relationship between the incidence of plantar ulcers and vitamin D defi ciency. Keywords: vitamin D, diabetes mellitus, neuropathyPutz, Zs., Martos, T., Németh, N., Körei, A. E., Szabó, M., Vági, O. E., Kempler, M. S., Kempler, P. (2013). [Vitamin D and neuropathy]. Orv. Hetil., 154(51), 2012-2015. (Beérkezett: 2013 elfogadva: 2013. október 31.) A szerkesztőség felkérésére készült közlemény.

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Section: A D-vitamin Szerepe a Neuropathia Kialakulásábanunclassified

Vitamin D and neuropathy

et al. 2013

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“…This was demonstrated in studies where peripheral neuropathy was determined via objective testing (1, 3), by self-reported symptoms of peripheral neuropathy (2), in a case report of the reversal of severe pain with correction of 25(OH)D deficiency (22), and in a nonrandomized, non-blinded trial of 51 type 2 diabetic patients with 25(OH)D insufficiency and neuropathic pain where a significant reduction in pain scores after 3 months supplementation with cholecalciferol tablets (average dose, 2059 IU) was shown (23). …”

Section: Discussionmentioning

confidence: 88%

“…Recent studies have suggested that low 25(OH)D levels may be related to the development of diabetic peripheral neuropathy (1–3). The etiology of diabetic neuropathy is multifactorial with metabolic and neurovascular involvement.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Insufficiency is Associated With Reduced Parasympathetic Nerve Fiber Function in Type 2 Diabetes

2015

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Objective Vitamin D insufficiency is prevalent in type 2 diabetes mellitus (T2DM) and is associated with peripheral neuropathy. There is little data, however, for cardiovascular autonomic neuropathy. Our objective was to evaluate the association of cardiovascular autonomic function, 25-hydroxyvitamin D (25(OH)D) insufficiency (i.e., levels <30 ng/mL), and multiple metabolic parameters in T2DM. Methods We examined 50 individuals with T2DM. Cardiovascular autonomic function was assessed by RR-variation during deep breathing (i.e., mean circular resultant (MCR), expiration/inspiration (E/I) ratio). These measures assess parasympathetic function. Metabolic parameters included measures of adiposity, glycemic control, insulin resistance, calcium metabolism and 25(OH)D. Results Participants with 25(OH)D insufficiency (n=26) were younger (66±9 vs. 60±10 years, p<0.05), more insulin resistant, had a higher body mass index and lower adiponectin levels. The MCR (39.5±26.3 vs. 27.6±17.2, p<0.01) and E/I ratio (1.21±0.17 vs. 1.15±0.09, p<0.01) were lower for those with 25(OH)D insufficiency, after controlling for age. A stepwise selection procedure regressing MCR and E/I ratio on a number of metabolic parameters resulted in a model identifying age and 25(OH)D insufficiency as significant determinants for both measures. The interaction of age×25(OH)D insufficiency was also included (MCR model, R2=0.491, p<0.001; E/I ratio, R2=0.455, p<0.001). Neither glycemic control nor other metabolic parameters were selected. Conclusion Our results suggest that 25(OH)D insufficiency is associated with reduced parasympathetic function, the association being stronger in younger persons with T2DM. Studies are needed to determine if vitamin D supplementation into the sufficient range could prevent or delay the onset of cardiovascular autonomic dysfunction.

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“…Similarly Vitamin D deficiency is also suspected to play some role in development of diabetic neuropathy (17) . Management of painful diabetic neuropathy has always been a challenge and requires selection of circumstantially suitable treatment option (18) .…”

Section: Discussionmentioning

confidence: 99%

Comparison of clinical effectiveness of laser acupuncture and amitriptyline in diabetic peripheral neuropathy (DPN): a sham controlled randomized clinical trial

Khan

Anwar²,

Hanif

et al. 2014

SPIE Proceedings

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Background: Painful neuropathy is a very common complication in diabetic patients. Various treatment strategies like manual therapies, conservative management, drug therapy and exercise have been opted for this problem. Studies have shown clinical effectiveness of laser acupuncture as well. On the other hand, Amitryptaline is also a commonly used treatment for this disease. We aim to compare the efficacy of both treatments.

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Vitamin D deficiency and peripheral diabetic neuropathy

Cited by 46 publications

References 9 publications

Vitamin D and neuropathy

Vitamin D and neuropathy

Vitamin D Insufficiency is Associated With Reduced Parasympathetic Nerve Fiber Function in Type 2 Diabetes

Comparison of clinical effectiveness of laser acupuncture and amitriptyline in diabetic peripheral neuropathy (DPN): a sham controlled randomized clinical trial

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