Vitamin D deficiency and anemia

Özsoylu, Şînasi; Aytekin, Mahmut Nedim

doi:10.1007/s00277-010-1078-y

Cited by 5 publications

(5 citation statements)

References 3 publications

(4 reference statements)

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“…Our findings are in agreement with Özsoylu and Aytekin, who could not find a relationship between anaemia and rickets due to vitamin D deficiency ( 30 ) , but disagree with Yoon et al . ( 31 ) and Grindulis et al .…”

Section: Discussionsupporting

confidence: 85%

Hb level in relation to vitamin D status in healthy infants and toddlers

Abdul‐Razzak

Khoursheed

Altawalbeh

et al. 2012

Public Health Nutr.

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Section: Discussionsupporting

confidence: 85%

Hb level in relation to vitamin D status in healthy infants and toddlers

Abdul‐Razzak

Khoursheed

Altawalbeh

et al. 2012

Public Health Nutr.

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“…Restriction of dietary vitamin D reverses accelerated aging in mice deficient in either FGF23 or Klotho [11][12][13]. Mounting epidemiological evidence suggests that vitamin D deficiency is associated with anemia [14][15][16][17][18][19][20]. Previous clinical observations have shown that vitamin D deficiency is linked to decreased haemoglobin, enhanced reticulocytosis and a reduced response to erythropoiesisstimulating agents [20,21].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D-Rich Diet in Mice Modulates Erythrocyte Survival

Lang

Jilani

Bissinger

et al. 2015

Kidney Blood Press Res

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Background/Aims: Epidemiological evidence suggests that vitamin D deficiency is associated with anemia. The potent metabolite 1,25(OH)₂ vitamin D₃ [1,25(OH)₂D₃] activates various signaling cascades regulating a myriad of cellular functions including suicidal cell death or apoptosis. Suicidal death of erythrocytes or eryptosis is characterized by cell shrinkage and cell membrane scrambling leading to phosphatidylserine (PS) externalization. Stimulation of eryptosis may limit lifespan of circulating erythrocytes and thus cause anemia. In the present study, we explored the effect of a high vitamin D diet (10,000 I.U. vitamin D for 14 days) in mice on eryptosis. Methods: Plasma concentrations of erythropoietin were estimated using an immunoassay kit, blood count using an electronic hematology particle counter, relative reticulocyte numbers using Retic-COUNT® reagent, PS exposure at the cell surface from annexin V binding, cell volume from forward scatter, and cytosolic Ca²⁺ ([Ca²⁺]_i) from Fluo3-fluorescence in FACS analysis. Results: Vitamin D treatment decreased mean corpuscular volume, reticulocyte count, and plasma erythropoietin levels. Vitamin D treatment slightly but significantly decreased forward scatter but did not significantly modify spontaneous PS exposure and [Ca²⁺]_i of freshly drawn erythrocytes. Vitamin D treatment augmented the stimulation of PS exposure and cell shrinkage following exposure to hyperosmotic shock (addition of 550 mM sucrose) or energy depletion (glucose removal) without significantly modifying [Ca²⁺]_i. Conclusions: The present observations point to a subtle effect of exogenous vitamin D supplementation on erythrocyte survival.

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“…Nutritional deficiency of iron may result in development of iron deficiency anemia (IDA), which leads to a total burden of about 75 to 80% of anemia cases (Milman, 2011). Similarity, a lack of nutritional elements such as folate (Al Khatib et al, 2006;de Benoist, 2008), vitamin B12 (Pinto et al, 1973), and vitamin D (Özsoylu and Aytekin, 2011) can also contribute to anemia. Moreover, microbe invasion is also another important pathogenic factor for anemia; for example, malaria parasite can lead to sequestration in the placental vascular space with consequent maternal anemia (Shulman et al, 1996;Cot et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota Signatures in Gestational Anemia

Long

Fang²,

Guo³

et al. 2021

Front. Cell. Infect. Microbiol.

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Gestational diseases are associated with altered intestinal microbiota in pregnant women. Characterizing the gut microbiota of gestational anemia (GA) may describe a novel role of gut microbial abnormality in GA. In this study, we investigated differences in gut microbiota between GA patients and healthy pregnant women from the first trimester (n = 24 vs. 54) and the third trimester (n = 30 vs. 56) based on the 16S rRNA gene sequencing method. No statistically significant differences in α-diversity were identified between GA patients and controls in the first trimester of pregnancy, whereas the Shannon index and observed OTUs were significantly lower in GA patients than in healthy controls in the third trimester. Distance-based redundancy analysis revealed striking differences in microbial communities in the third trimester between GA patients and controls. Four genera were significantly different in relative abundance between GA patients and healthy controls, while 12 genera differentiated significantly between GA patients and healthy controls in the third trimester. At the operational taxonomic unit (OTU) level, 17 OTUs and 30 OTUs were identified to be different between GA patients and healthy controls in the first and third trimesters, respectively. Changes in gut microbial composition of GA patients suggest a potential relation with GA, and provide insights into the prediction and intervention of gestational anemia.

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Vitamin D deficiency and anemia

Cited by 5 publications

References 3 publications

Hb level in relation to vitamin D status in healthy infants and toddlers

Hb level in relation to vitamin D status in healthy infants and toddlers

Vitamin D-Rich Diet in Mice Modulates Erythrocyte Survival

Gut Microbiota Signatures in Gestational Anemia

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