Gut Microbiota Signatures in Gestational Anemia

Long, Yan; Fang, Liang; Guo, Ruochun; Zhu, Chunyan; Zhao, Xin; Wang, Xifan; Liu, Fei; Jiang, Min; Liang, Qihua; Zeng, Shanshui; Han, Mengru; Qin, Junjie; Li, Shenghui; Li, Shaochuan; Yang, Hongling

doi:10.3389/fcimb.2021.549678

Cited by 6 publications

(6 citation statements)

References 51 publications

(51 reference statements)

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“…Although the NGS data did not show significant differences between groups, PCR validation experiments confirmed significant differences between IDA patients before and after iron supplementation. In a previous clinical study, a decrease in Faecalibacterium was identified as an important biomarker in subjects with gestational anemia compared with normal subjects, which is similar to the results of this study [ 55 ]. However, more research on Faecalibacterium in iron metabolism and IDA is needed.…”

Section: Discussionsupporting

confidence: 90%

The Effects of Iron Deficiency on the Gut Microbiota in Women of Childbearing Age

et al. 2023

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Iron deficiency anemia (IDA) is the most prevalent and common nutritional deficiency worldwide and is a global health problem with significant risk, particularly among women of reproductive age. Oral iron supplementation is the most widely used and cost-effective treatment for iron deficiency and IDA. However, there are limitations regarding side effects such as enteritis, treatment compliance, and bioavailability. Intestinal microbiome characteristic research has been recently conducted to overcome these issues, but more is needed. Against this background, a metagenomics study on the 16S gene in the feces of young women vulnerable to IDA was conducted. As a result of analyzing 16 normal subjects and 15 IDA patients, significant differences in bacterial community distribution were identified. In particular, a significant decrease in Faecalibacterium was characteristic in IDA patients compared with normal subjects. Furthermore, in the case of patients who recovered from IDA following iron supplementation treatment, it was confirmed that Faecalibacterium significantly recovered to normal levels. However, no significance in beta diversity was seen compared with before treatment. There were also no differences in the beta diversity results between the recovered and normal subjects. Therefore, intestinal dysbiosis during the disease state was considered to be restored as IDA improved. Although the results were derived from a limited number of subjects and additional research is needed, the results of this study are expected to be the basis for developing treatment and prevention strategies based on host–microbiome crosstalk in IDA.

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Section: Discussionsupporting

confidence: 90%

The Effects of Iron Deficiency on the Gut Microbiota in Women of Childbearing Age

et al. 2023

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“…In the current study, we delineated that GA microbial dysbiosis was characterized by several bacterial genera and structured CAG. A cross-sectional anemia classifier in the first trimester and second trimester has been constructed ( Long et al., 2021 ); however, limited efforts have been made to prospectively predict future anemic women. The greatest advantage was that for the first time, a prediction model for upcoming anemia in normal pregnant women with relatively high discriminatory power was established based on novel gut microbial signatures.…”

Section: Discussionmentioning

confidence: 99%

“…Microbial signatures have been elucidated to function as novel biomarkers to discriminate patients suffering from illness and healthy individuals ( Liu et al., 2019 ; Wei et al., 2020 ). To date, an anemia classifier in pregnancy has been constructed ( Long et al., 2021 ); however, no efforts have been made to predict the subsequent incidence of anemia in normal gestational women.…”

Section: Introductionmentioning

confidence: 99%

Insight Into the Potential Value of Gut Microbial Signatures for Prediction of Gestational Anemia

Wei

Deng

Qin

et al. 2021

Front. Cell. Infect. Microbiol.

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The gut microbiota alternations are associated with gestational anemia (GA); however, limited predictive value for the subsequent incidence of anemia in normal gestational women has been obtained. We sought to rigorously characterise gut dysbiosis in subjects with GA and explored the potential predictive value of novel microbial signatures for the risk of developing GA. A prospective cohort of subjects with GA (n = 156) and healthy control (n = 402), all of whom were free of GA in the second trimester, by 16S rRNA gene sequencing was conducted. Microbial signatures altered dramatically in GA compared with healthy control in the second trimester. Megamonas, Veillonella, and Haemophilus were confirmed to show differential abundances in GA after adjusting for covariates. On the contrary, Lachnospiraceae and Blautia were enriched in control. Microbial co-abundance group (CAG) network was constructed. Prospectively, CAG network relatively accurately predicted upcoming GA in normal pregnant women with an AUC of 0.7738 (95%CI: 0.7171, 0.8306) and the performance was further validated in Validation set (0.8223, 95%CI: 0.7573, 0.8874). Overall, our study demonstrated that alterations in the gut microbial community were associated with anemia in pregnancy and microbial signatures could accurately predict the subsequent incidence of anemia in normal pregnant women. Our findings provided new insights into understanding the role of gut microbiota in GA, identifying high-risk individuals, and modulating gut microbiota as a therapeutic target, thus improving quality of life and well-being of women and children.

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“…In fact, transplantation of gut microbiota from pregnant individuals into germ-free animal models, renders common pregnancy phenotypes of obesity, insulin resistance (19,22), and adaptations in immunity (23). Poor diet quality leading to a pro-inflammatory state can alter the normal dynamic changes of the gut microbiota (14) and immune system during pregnancy (24), increasing risk of common perinatal complications, including GDM (25), iron deficiency (26), and mood disorders (27). It is thus essential to understand how maternal diet quality during pregnancy impacts the gut microbiota.…”

Section: Introductionmentioning

confidence: 99%

“…(25), iron deficiency (26), and mood disorders (27). It is thus essential to understand how maternal diet quality during pregnancy impacts the gut microbiota.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory dietary potential is associated with vitamin depletion and gut microbial dysbiosis in early pregnancy

Alvernaz,

Wenzel,

Nagelli

et al. 2023

Preprint

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BackgroundPregnancy alters many physiological systems, including the maternal gut microbiota. Diet is a key regulator of this system and can alter host inflammation. Multiple perinatal disorders have been associated with inflammation, maternal metabolic alterations, and gut microbiota dysbiosis, including gestational diabetes mellitus, preeclampsia, preterm birth, and mood disorders. However, the effects of high inflammatory diets on the gut microbiota during pregnancy has yet to be fully explored.ObjectiveTo use a systems-based approach to characterize associations among dietary inflammatory potential, a measure of diet quality, and the gut microbiome during pregnancy.MethodsForty-nine pregnant persons were recruited prior to 16 weeks of gestation. Participants completed a food frequency questionnaire (FFQ) and provided fecal samples. Dietary inflammatory potential was assessed using the Dietary Inflammatory Index (DII) from FFQ data. Fecal samples were analyzed using 16S rRNA amplicon sequencing. Differential taxa abundance with respect to DII score were identified, and microbial metabolic potential was predicted using PICRUSt2.ResultsInflammatory diets were associated with decreased vitamin and mineral intake and dysbiotic gut microbiome structure and metabolism. Gut microbial compositional differences revealed a decrease in short chain fatty acid producers such as g_Faecalibacterium,upregulation of vitamin B12 synthesis, methylglyoxal detoxification, galactose metabolism and multi drug efflux systems in pregnant individuals with increased DII scores.ConclusionsDietary inflammatory potential was associated with depletion of vitamins & minerals and gut microbiota metabolic dysregulation.

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Gut Microbiota Signatures in Gestational Anemia

Cited by 6 publications

References 51 publications

The Effects of Iron Deficiency on the Gut Microbiota in Women of Childbearing Age

The Effects of Iron Deficiency on the Gut Microbiota in Women of Childbearing Age

Insight Into the Potential Value of Gut Microbial Signatures for Prediction of Gestational Anemia

Inflammatory dietary potential is associated with vitamin depletion and gut microbial dysbiosis in early pregnancy

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