Insight Into the Potential Value of Gut Microbial Signatures for Prediction of Gestational Anemia

Wei, Hongcheng; Deng, Siting; Qin, Yufeng; Xu, Yang; Chen, Ting; Wang, Xu; Xia, Yankai

doi:10.3389/fcimb.2021.734561

Cited by 5 publications

(5 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although an increase in the relative abundance of Megamonas in ART‐treated HIV+ adults has been reported, 62 literature associating Megamonas with ID is scarce. A study in women with gestational anaemia reported gut microbial enrichment of Megamonas 63 . In HIV+ adults either on ART or ART naive, Megamonas was correlated significantly with interleukin‐6, a systemic inflammatory cytokine 64 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Associations of HIV and iron status with gut microbiota composition, gut inflammation and gut integrity in South African school‐age children: a two‐way factorial case–control study

Goosen

Proost

Baumgartner

et al. 2023

J Human Nutrition Diet

View full text Add to dashboard Cite

Background: Human immunodeficiency virus (HIV) and iron deficiency (ID) affect many African children. Both HIV and iron status interact with gut microbiota composition and related biomarkers. The study's aim was to determine the associations of HIV and iron status with gut microbiota composition, gut inflammation and gut integrity in South African school-age children. Methods: In this two-way factorial case-control study, 8-to 13-year-old children were enrolled into four groups based on their HIV and iron status: (1) With HIV (HIV+) and ID (n = 43), (2) HIV+ and iron-sufficient nonanaemic (n = 41), (3) without HIV (HIV−) and ID (n = 44) and (4) HIV− and ironsufficient nonanaemic (n = 38). HIV+ children were virally suppressed (<50 HIV RNA copies/ml) on antiretroviral therapy (ART). Microbial composition of faecal samples (16S rRNA sequencing) and markers of gut inflammation (faecal calprotectin) and gut integrity (plasma intestinal fatty acid-binding protein [I-FABP]) were assessed. Results: Faecal calprotectin was higher in ID versus iron-sufficient nonanaemic children (p = 0.007). I-FABP did not significantly differ by HIV or iron status. ART-treated HIV (redundancy analysis [RDA] R 2 = 0.009, p = 0.029) and age (RDA R 2 = 0.013 p = 0.004) explained the variance in the gut microbiota across the four groups. Probabilistic models showed that the relative abundance of the butyrate-producing genera Anaerostipes and Anaerotruncus was lower in ID versus iron-sufficient children. Fusicatenibacter was lower in HIV+ and in ID children versus their respective counterparts. The prevalence of the inflammation-associated genus Megamonas was 42%

show abstract

Section: Discussionmentioning

confidence: 99%

“…A study in women with gestational anaemia reported gut microbial enrichment of Megamonas . 63 In HIV+ adults either on ART or ART naive, Megamonas was correlated significantly with interleukin‐6, a systemic inflammatory cytokine. 64 In our study, HIV was significantly associated with increases in both CRP and AGP concentrations.…”

Section: Discussionmentioning

confidence: 99%

Associations of HIV and iron status with gut microbiota composition, gut inflammation and gut integrity in South African school‐age children: a two‐way factorial case–control study

Goosen

Proost

Baumgartner

et al. 2023

J Human Nutrition Diet

View full text Add to dashboard Cite

show abstract

“…The study was based on the Mother and Child Microbiome Cohort (MCMC) Study 16 , 18 . The study design is presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Evidence indicated that the community structure of the gut microbiota changes dramatically throughout pregnancy 12 , 13 , and perturbed gut microbiota during pregnancy was found to be associated with multiple commodities such as GDM 14 and inflammatory bowel disease 15 . Evidence also indicated the role of gut microbiota in predicting metabolic disorders 16 , 17 . However, whether the dynamic change of gut microbiota during gestation was associated with dyslipidemia and whether the gut microbiota structure can predict the risk of dyslipidemia is unknown.…”

Section: Introductionmentioning

confidence: 99%

Ecological change of the gut microbiota during pregnancy and progression to dyslipidemia

Zhang

et al. 2023

npj Biofilms Microbiomes

Self Cite

View full text Add to dashboard Cite

The composition of the gut microbiome was previously found to be associated with clinical responses to dyslipidemia, but there is limited consensus on the dynamic change of the gut microbiota during pregnancy and the specific microbiome characteristics linked to dyslipidemia in pregnant women. We collected fecal samples from 513 pregnant women at multiple time points during pregnancy in a prospective cohort. Taxonomic composition and functional annotations were determined by 16S rRNA amplicon sequencing and shotgun metagenomic sequencing. The predictive potential of gut microbiota on the risk of dyslipidemia was determined. The gut microbiome underwent dynamic changes during pregnancy, with significantly lower alpha diversity observed in dyslipidemic patients compared to their healthy counterparts. Several genera, including Bacteroides, Paraprevotella, Alistipes, Christensenellaceae R7 group, Clostridia UCG-014, and UCG-002 were negatively associated with lipid profiles and dyslipidemia. Further metagenomic analysis recognized a common set of pathways involved in gastrointestinal inflammation, where disease-specific microbes played an important role. Machine learning analysis confirmed the link between the microbiome and its progression to dyslipidemia, with a micro-averaged AUC of 0.824 (95% CI: 0.782-0.855) combined with blood biochemical data. Overall, the human gut microbiome, including Alistipes and Bacteroides, was associated with the lipid profile and maternal dyslipidemia during pregnancy by perturbing inflammatory functional pathways. Gut microbiota combined with blood biochemical data at the mid-pregnancy stage could predict the risk of dyslipidemia in late pregnancy. Therefore, the gut microbiota may represent a potential noninvasive diagnostic and therapeutic strategy for preventing dyslipidemia in pregnancy.

show abstract

“…Megamonas could act as a beneficial microbe. However, the overgrowth of Megamonas could be involved in the occurrence of gestational anemia ( Wei et al, 2021 ). Increased Megamonas abundance has been demonstrated to be associated with major depressive disorder ( Wang et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

The interplay between the gut microbiota and metabolism during the third trimester of pregnancy

et al. 2022

View full text Add to dashboard Cite

The gut microbiota undergoes dynamic changes during pregnancy. The gut microbial and metabolic networks observed in pregnant women have not been systematically analyzed. The primary purpose of this study was to explore the alterations in the gut microbiota and metabolism during late pregnancy and investigate the associations between the gut microbiota and metabolism. A total of thirty healthy pregnant women were followed from 30 to 32 weeks of gestation to full term. Fecal samples were collected for microbiome analysis and untargeted metabolomic analysis. The characteristics of the gut microbiota were evaluated by 16S ribosomal RNA gene sequencing of the V3-V4 regions. The plasma samples were used for untargeted metabolomic analysis with liquid chromatography–tandem mass spectrometry. The interplay between the gut microbiota and metabolism was analyzed further by bioinformatics approaches. We found that the relative abundances of Sellimonas and Megamonas were higher at full term, whereas that of Proteobacteria was lower. The correlation network of the gut microbiota tended to exhibit weaker connections from 32 weeks of gestation to the antepartum timepoint. Changes in the gut microbiota during late pregnancy were correlated with the absorbance and metabolism of microbiota-associated metabolites, such as fatty acids and free amino acids, thereby generating a unique metabolic system for the growth of the fetus. Decreasing the concentration of specific metabolites in plasma and increasing the levels of palmitic acid and 20-hydroxyarachidonic acid may enhance the transformation of a proinflammatory immune state as pregnancy progresses.

show abstract

Insight Into the Potential Value of Gut Microbial Signatures for Prediction of Gestational Anemia

Cited by 5 publications

References 39 publications

Associations of HIV and iron status with gut microbiota composition, gut inflammation and gut integrity in South African school‐age children: a two‐way factorial case–control study

Associations of HIV and iron status with gut microbiota composition, gut inflammation and gut integrity in South African school‐age children: a two‐way factorial case–control study

Ecological change of the gut microbiota during pregnancy and progression to dyslipidemia

The interplay between the gut microbiota and metabolism during the third trimester of pregnancy

Contact Info

Product

Resources

About