Vitamin D – current stage of knowledge about analysis and supplementation

Starek, Małgorzata; Mierzwa, Justyna; Gumułka, Paweł; Dąbrowska, Monika

doi:10.1080/10408398.2021.1877110

Cited by 5 publications

(5 citation statements)

References 94 publications

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“…In addition to dosage, the duration of supplementation is also a risk factor for toxicosis. 12,91 In humans, the serum 25(OH)D 3 response to vitamin D supplementation peaks and plateaus at approximately 3 mon. 36,61 In this case, 25(OH)D 3 had not plateaued at 6 mon when the supplement was discontinued, implying that an increase in serum levels may have continued with additional weeks of supplementation.…”

Section: Discussionmentioning

confidence: 99%

Experimental Cholecalciferol Supplementation in a Herd of Managed Asian Elephants (Elephas Maximus)

Childs-Sanford¹,

Makowski²,

Hilliard³

et al. 2023

Journal of Zoo and Wildlife Medicine

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Vitamin D supplementation may pose a significant health risk in species where levels of deficiency, sufficiency, and toxicity have not been clearly established, and species-specific research on vitamin D supplementation should be performed. This study documented the effect of vitamin D supplementation on serum vitamin D metabolites and other analytes of Ca homeostasis in Asian elephants (Elephas maximus). Six adult Asian elephants received PO supplementation with cholecalciferol at 300 IU/kg of body weight (BW) once a week for 24 wk. Serum was analyzed every 4 wk for 25-hydroxyvitamin D2/D3 [25(OH)D]; 24,25-dihydroxyvitamin D2/D3 [24,25(OH)2D]; 1,25-dihydroxyvitamin D [1,25(OH)2D]; parathyroid hormone (PTH); total Ca; ionized Ca (iCa); P; and Mg. After the supplement was discontinued, serum 25(OH)D2/D3 was measured every 4 wk until levels returned to baseline. At the start of the study, the average serum 25(OH)D3 was nondetectable (,1.5 ng/ml).With cholecalciferol supplementation, 25(OH)D3 increased at an average rate of 2.26 ng/ml per month and reached an average concentration of 12.9 6 3.46 ng/ml at 24 wk. Both 24,25(OH)2D3 and 1,25(OH)2D increased over time with supplementation from an average of ,1.5 to 12.9 ng/ml and from 9.67 to 36.4 pg/ml, respectively. PTH, iCa, Ca, P, and Mg remained within reported normal ranges throughout supplementation. After the supplement was discontinued, serum 25(OH)D3 demonstrated a slow decline to baseline, taking an average of 48 wk. Elephants demonstrated significant individual variation in response to supplementation and subsequent return to baseline. Supplementation of Asian elephants with a weekly dose of 300 IU/kg BW cholecalciferol for 24 wk appears to be effective and safe. Additional clinical studies would be necessary to investigate the safety of other routes of administration, dosages, and duration of vitamin D supplementation, as well as associated health benefits.

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Section: Discussionmentioning

confidence: 99%

Experimental Cholecalciferol Supplementation in a Herd of Managed Asian Elephants (Elephas Maximus)

Childs-Sanford¹,

Makowski²,

Hilliard³

et al. 2023

Journal of Zoo and Wildlife Medicine

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“…Children of mothers with adequate vitamin D levels have fewer enamel abnormalities, attention deficit and hyperactivity problems, and autism [38]. People also use vitamin D for weak and brittle bones, heart disease [39], asthma, hay fever, and many other conditions. Support from vitamin D lowers insulin resistance and improves blood pressure profiles [40].…”

Section: Applications Of Vitamin Dmentioning

confidence: 99%

The Effects of Vitamin D on Preventing Hyperglycemia and a Novel Approach to Its Treatment

Monapati,

Kaki,

Gurajapu

et al. 2023

DDC

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The dietary reference levels for vitamin D were established with an emphasis on its role in bone health; however, with the identification of vitamin D receptors in all body tissues novel associations with other metabolic disorders, such as diabetes, are being researched. Aside from its standard function as the main regulator of calcium absorption, vitamin D also controls the calcium pool, mediates the activity of beta cell calcium-dependent endopeptidases, encourages the conversion of proinsulin to insulin, increases insulin output, and raises insulin activity in peripheral insulin target tissues. Both immune cells and pancreatic beta cells include vitamin D receptors. A deficiency of vitamin D causes glucose intolerance and affects insulin secretion. Different pathogenic characteristics of the disease are linked to a number of vitamin D-related genes. It has been proven that vitamin D supplementation lowers the risk of type 1 and type 2 diabetes and its associated problems. In this article, we discussed a few prospective clinical trials on vitamin D that are necessary to clearly demonstrate the role of vitamin D in the prevention and management of diabetes.

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“…On page 7, Section 2, third paragraph, line 2, the sentence "The lack of safety insight has been counteracted by numerous studies showing different results concerning the positive effects of food supplements and quality products traded in Europe, including metal in preparations of spirulina tablets [38]; vitamin D [39]; ginseng herbal medicine control and authentication [40]; cottonseed oil and cottonseed meal supplementation [41]; supplemental lycopene on cardiovascular risk factor [42]; and propolis as an antioxidant and antimicrobial [43]". Has be updated to "The lack of safety insight has been counteracted by numerous studies showing different results concerning the positive effects of food supplements and quality products traded in Europe, including testosterone-boosting supplements (T-Boosters) [45], metal in preparations of spirulina tablets [46], vitamin D [47], ginseng herbal medicine control and authentication [48], cottonseed oil and cottonseed meal supplementation [49], supplemental lycopene on the cardiovascular risk factor [50], and propolis as an antioxidant and antimicrobial agent [51]".…”

Section: Text Correctionsmentioning

confidence: 99%

Correction: Raposo et al. The Role of Food Supplementation in Microcirculation—A Comprehensive Review. Biology 2021, 10, 616

Raposo,

Saraiva,

Ramos

et al. 2023

Biology

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Vitamin D – current stage of knowledge about analysis and supplementation

Cited by 5 publications

References 94 publications

Experimental Cholecalciferol Supplementation in a Herd of Managed Asian Elephants (Elephas Maximus)

Experimental Cholecalciferol Supplementation in a Herd of Managed Asian Elephants (Elephas Maximus)

The Effects of Vitamin D on Preventing Hyperglycemia and a Novel Approach to Its Treatment

Correction: Raposo et al. The Role of Food Supplementation in Microcirculation—A Comprehensive Review. Biology 2021, 10, 616

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