Vitamin D Concentrations and Obstructive Sleep Apnea in a Multicenter Cohort of Older Males

Goswami, Umesh; Ensrud, Kristine E.; Paudel, Misti L.; Redline, Susan; Schernhammer, Eva; Shikany, James M.; Stone, Katie L.; Kunisaki, Ken M.

doi:10.1513/annalsats.201507-440oc

Cited by 31 publications

(29 citation statements)

References 32 publications

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“…In addition, some studies examining the relationship between mild, moderate, and severe OSAS patients and vitamin D levels reported that there was no significant relationship (12,15). However, there are more studies in the literature claiming that vitamin D level decreases as disease severity increases, indicating a negative relationship (10)(11)13,16). There are studies indicating that this relationship is significant, especially in patients with severe OSAS (14,17).…”

Section: Discussionmentioning

confidence: 99%

The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D

Kul¹,

Araz²

2020

Van Med J

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Obstructive sleep apnea syndrome (OSAS) is a condition which causes recurrent respiratory dysfunction (apnea, hypopnea) during sleep because of the obstruction of the upper respiratory tract and is a significant health problem that may affect various systems of the body (1). Although the pathogenesis of OSAS is not known, it might stem from many other causes, including differing mechanisms like inflammation and oxidative stress (2). While obesity is one of the primary factors, agedness, male gender, ethnic origin, and family history are among other risk factors (1). The data published in the literature emphasizes the relationship between OSAS and a variety of impairments including cardiovascular diseases, ABSTRACT Introduction: The aim of this study was to assess vitamin D levels in obstructive sleep apnea syndrome (OSAS) and whether there is a relationship between the severity of the disease and vitamin D. Materials and Methods: In this retrospective study, demographic data, serum 25-Hydroxycholecalciferol [25 (OH) D3], parathyroid hormone (PTH), calcium (Ca), phosphate (P), magnesium (Mg) levels and disease severity [mild, moderate and severe OSAS (AHI = 5-15, 16-30,> 30 / hour)] of patients diagnosed with OSAS by using polysomnography [apnea-hypopnea index (AHI> 5/hour] and normal patients (AHI <5/hour)] were evaluated based on hospital records. Results: Of the 293 subjects whose records were examined, 229 had OSAS (mean age 55.7 ± 11.3 years; age range 26-86 years), whereas 64 subjects were normal (mean age 55.4 ± 13.7 years; age range 24-78 years). 25 (OH) D3 level was significantly lower while BMI and PTH levels were higher in OSAS patients compared to the control group (p <0.05). 25 (OH) D3 levels were significantly lower in patients with severe OSAS (p <0.05). In addition, there was a weak negative relationship between AHI and 25 (OH) D3 (p: 0.001, r:-0.328), while a weak positive relationship was observed between PTH (p: 0.001, r: 0.186) and BMI (p: 0.001, r: 0.208). Conclusion: OSAS patients have vitamin D deficiency, and patients especially with severe OSAS have lower vitamin D deficiency. Therefore, We think that making up of vitamin D deficiency in these patients may be beneficial in reducing the severity of the disease.

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Section: Discussionmentioning

confidence: 99%

The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D

Kul¹,

Araz²

2020

Van Med J

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“…In addition, information on other sleeprelated disturbances or disorders, including sleep apnoea, were not collected in our study. Several studies have reported that sleep apnoea was associated with lower serum 25OHD levels [79][80][81][82][83][84][85][86][87]. Furthermore, it remains possible that the associations between sleep and vitamin D status may be due to associations with poor health [88], including unmeasured confounding variables such as depression [89] and musculoskeletal pain [39] or inflammation [90]; these unmeasured confounding variables may differ by sex especially in Chinese populations.…”

Section: Plos Onementioning

confidence: 99%

Sleep duration is associated with vitamin D deficiency in older women living in Macao, China: A pilot cross-sectional study

Liang²,

et al. 2020

PLoS ONE

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Chinese women are known to have both a high prevalence of metabolic syndrome (MetS) and vitamin D deficiency (serum 25-hydroxyvitamin D (25OHD) <50 nmol/l). Associations between sleep duration and circulating 25OHD have recently been reported but, to our knowledge, these associations have not been studied in older Chinese populations. We thus investigated whether sleep duration was associated with vitamin D status in a population from Macao, China, and whether sleep duration modified the association between MetS and vitamin D deficiency. In 207 older (>55 years) Macanese, anthropometry, blood samples and validated questionnaires, including sleep duration and cardiovascular risk factors, were simultaneously collected. On multivariable categorical analyses, those women, not men, who had short sleep duration (�6 hours (h)) were at a 2-fold risk for vitamin D deficiency (both <50 nmol/L and <37 nmol/L; OR = 1.94, 95%CI 1.29-2.92; OR = 2.05, 95%CI 1.06-3.98, respectively) and those who had longer sleep duration (>8 h) were 3-fold more likely to have vitamin D deficiency (OR = 3.07, 95%CI 1.47-6.39; OR = 2.75, 95%CI 1.08-7.00, respectively) compared to those with normal sleep duration (6-8 h). Both women and men with MetS were 2-fold more likely to have vitamin D deficiency (women: OR = 2.04, 95%CI 1.31-3.17; OR = 2.15, 95%CI 1.11-4.17, respectively; men: OR = 2.01, 95%CI 1.23-3.28; OR = 2.04, 95%CI 1.00-4.29, respectively). Moreover, women with both short sleep duration and MetS had an increased risk of vitamin D deficiency (OR = 3.26, 95%CI 1.10-9.64). These associations were not found in those with longer sleep. Men with longer sleep and MetS had a 5-fold risk of vitamin D deficiency (OR = 5.22; 95%CI 2.70-10.12). This association was non-significant for men with shorter sleep. We conclude that both short and long sleep duration were associated with vitamin D deficiency in older Chinese women. Further research is needed in larger cohorts or with intervention studies to further examine the associations between reduced sleep, metabolic syndrome and vitamin D deficiency.

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“…[6][7][8] We and others have observed widespread vitamin D OSA. [9][10][11][12][13][14] Interestingly, 25(OH)D levels have been shown to be inversely correlated with OSA severity 10,11,13 and with metabolic alterations associated with OSA, including abnormal glucose metabolism 11,12 and nocturnal heart rate.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8] A recent study suggested that the association between lower 25(OH) D and OSA was largely confounded by larger BMI and neck circumference. 9 In contrast, our group 10 and others [11][12][13][14] have reported a high rate of vitamin D deficiency in OSA, where vitamin D levels (25(OH)D) are lower in severe OSA 10,11,13 and inversely correlate with some of its associated metabolic alterations, including abnormal glucose metabolism 11,12 as well as nocturnal heart rate. 10 Vitamin D receptors are located systemically and recent advances have demonstrated the potential of vitamin D to influence a wide variety of organs.…”

mentioning

confidence: 81%

Vitamin D Improves Selected Metabolic Parameters but Not Neuropsychological or Quality of Life Indices in OSA: A Pilot Study

Kerley

Hutchinson

Bramham

et al. 2017

Journal of Clinical Sleep Medicine

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Study Objectives: Our group and others have reported a high rate of vitamin D deficiency in obstructive sleep apnea (OSA), where vitamin D levels (25(OH) D) correlate negatively with OSA severity and some of its associated metabolic alterations. Data regarding vitamin D supplementation in OSA are lacking. We wanted to evaluate the effect of vitamin D 3 supplementation on OSA symptoms and metabolic parameters.

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Vitamin D Concentrations and Obstructive Sleep Apnea in a Multicenter Cohort of Older Males

Abstract: Among community-dwelling older men, the association between lower 25(OH)D and sleep apnea was largely explained by confounding by larger body mass index and neck circumference.

Cited by 31 publications

References 32 publications

The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D

The Relation between Obstructive Sleep Apnea Syndrome and Vitamin D

Sleep duration is associated with vitamin D deficiency in older women living in Macao, China: A pilot cross-sectional study

Vitamin D Improves Selected Metabolic Parameters but Not Neuropsychological or Quality of Life Indices in OSA: A Pilot Study

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