Vitamin D, bones and muscle: myth versus reality

Duque, Gustavo; Daly, Robin M.; Sanders, Kerrie M.; Kiel, Douglas P.

doi:10.1111/ajag.12408

Cited by 21 publications

(12 citation statements)

References 27 publications

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“…Additionally, although the relationship between vitamin D and fall risk is suggestive, it remains inconclusive [ 44 ]. We anticipated vitamin D insufficient mice would exhibit worse rotarod performance, as rotarod is an indicator of balance and coordination [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Chronic vitamin D insufficiency impairs physical performance in C57BL/6J mice

Seldeen

Pang

Leiker

et al. 2018

Aging

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Vitamin D insufficiency (serum 25-OH vitamin D < 30 ng/ml) affects 70-80% of the general population, yet the long-term impacts on physical performance and the progression of sarcopenia are poorly understood. We therefore followed 6-month-old male C57BL/6J mice (n=6) consuming either sufficient (STD, 1000 IU) or insufficient (LOW, 125 IU) vitamin D3/kg chow for 12 months (equivalent to 20-30 human years). LOW supplemented mice exhibited a rapid decline of serum 25-OH vitamin D levels by two weeks that remained between 11-15 ng/mL for all time points thereafter. After 12 months LOW mice displayed worse grip endurance (34.6 ± 14.1 versus 147.5 ± 50.6 seconds, p=0.001), uphill sprint speed (16.0 ± 1.0 versus 21.8 ± 2.4 meters/min, p=0.0007), and stride length (4.4 ± 0.3 versus 5.1 ± 0.3, p=0.002). LOW mice also showed less lean body mass after 8 months (57.5% ± 5.1% versus 64.5% ± 4.0%, p=0.023), but not after 12 months of supplementation, as well as greater protein expression of atrophy pathway gene atrogin‑1. Additionally, microRNA sequencing revealed differential expression of mIR‑26a in muscle tissue of LOW mice. These data suggest chronic vitamin D insufficiency may be an important factor contributing to functional decline and sarcopenia.

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Section: Discussionmentioning

confidence: 99%

Chronic vitamin D insufficiency impairs physical performance in C57BL/6J mice

Seldeen

Pang

Leiker

et al. 2018

Aging

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“…Despite all the potential contributions of vitamin D to human health, there is no consensus regarding dosage and time/interval period of administration [2,32]. The factors influencing dose response to vitamin D supplementation (i.e., baseline vitamin D level, gender, ethnicity, body composition, calcium/phosphorus status, and genes) are well known, although the requirements for daily vs. weekly or monthly administration are still under debate [33].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Daily versus Monthly Administration: Bone Turnover and Adipose Tissue Influences

et al. 2018

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Vitamin D is involved in bone metabolism and in many various extra-skeletal diseases such as malabsorption syndromes, cardiovascular and metabolic diseases, cancer, and autoimmune and neurological diseases. However, data on the optimal route of administration are not consistent. The aims of our study were to analyze not only the influence of daily vs. monthly administration of vitamin D on bone metabolism and bone turnover, but also the effects of different routes of administration on fat mass in a cohort of adults with low levels of 25(OH) vitamin D3 at baseline. We analyzed 44 patients with hypovitaminosis at baseline and after six months of two different regimens of administration: seven drops (1750 IU)/day vs. 50,000 IU/month. We found that the two regimens were equivalent; 36 out of 44 patients reached the normal range of vitamin D after six months of treatment. Interestingly, the main determinant of vitamin D at baseline was the waist circumference. In addition, 22 patients treated by monthly regimen were evaluated after 18 months of treatment. At the end of follow-up, patients showed normal levels of vitamin D, with increased calcium levels and decreased bone turnover. Waist circumference also decreased. Our results support the efficacy of vitamin D3 given monthly both for correcting hypovitaminosis and for maintaining vitamin D levels. The relationship between serum 25(OH)vitamin D3 concentration and waist circumference supports vitamin D having a protective role in the current setting, since waist size is directly associated with the risk of cardiovascular and metabolic diseases.

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“…However, during menopause, the process of bone turnover increases and becomes uncoupled, resulting in a faster rate of bone resorption which cannot be compensated for by bone formation, resulting in an overall loss of bone (1). Sex hormone deficiency in postmenopause term in women and andropause term in men, suboptimal calcium and vitamin D intake or malnutrition and absance of exercise are the most seen osteoporosis etiologic causes (2). Drugs for osteoporosis can be classified as two major classes: anabolic agents and resorption inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Effect of Postmenopausal Strontium Ranelate Treatment on Oxidative Stress in Rat Skin Tissue

Berköz¹,

Sağır²,

Yalın³

et al. 2017

Eastern J Med

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Strontium ranelate is one of the most common post-menopausal osteoporosis medications that have been used in recent years. The effects of strontium ranelate treatment on the free radical-antioxidant balance of the skin have not been fully elucidated. In this study, we investigated the effects of strontium ranelate treatment on oxidative stress parameters in the skin tissue of rats with the experimental osteoporosis model. Total 35 rats were divided to five groups as control group (Group I), oophorectomy group (Group II), strontium ranelate group (Group III), oophorectomy + strontium ranelate group (immediately after the oophorectomy) (Group IV) and oophorecto my + strontium ranelat group (after three months of oophorectomy) (Group V). In Group III, IV and V, 500 mg/kg doses of strontium were given to rats by orally. At the end of the study, superoxide dismutase (SOD) and catalase activities, malondialdehyde (MD A) and glutathione (GSH) levels of the rats' skin tissues were determined. Catalase and SOD activities and GSH levels of all groups were significantly lower than Group I (p<0.05). MDA levels of all groups were significantly higher than Group I (p<0.05). Catalase and SOD activities and GSH levels of Group IV and V were significantly lower than Group II (p<0.05). MDA levels of Group IV and V were significantly higher than Group II (p<0.05). In conclusion, strontium ranelate treatment in oophorectomized rats has resulted in an increase in oxidative stress in skin tissue and can cause to several skin disorders.

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Vitamin D, bones and muscle: myth versus reality

Cited by 21 publications

References 27 publications

Chronic vitamin D insufficiency impairs physical performance in C57BL/6J mice

Chronic vitamin D insufficiency impairs physical performance in C57BL/6J mice

Vitamin D Daily versus Monthly Administration: Bone Turnover and Adipose Tissue Influences

Effect of Postmenopausal Strontium Ranelate Treatment on Oxidative Stress in Rat Skin Tissue

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