According to our results, Sr has preventive effect on oxidative damage in ovariectomized rats.

Strontium ranelate is one of the most common post-menopausal osteoporosis medications that have been used in recent years. The effects of strontium ranelate treatment on the free radical-antioxidant balance of the skin have not been fully elucidated. In this study, we investigated the effects of strontium ranelate treatment on oxidative stress parameters in the skin tissue of rats with the experimental osteoporosis model. Total 35 rats were divided to five groups as control group (Group I), oophorectomy group (Group II), strontium ranelate group (Group III), oophorectomy + strontium ranelate group (immediately after the oophorectomy) (Group IV) and oophorecto my + strontium ranelat group (after three months of oophorectomy) (Group V). In Group III, IV and V, 500 mg/kg doses of strontium were given to rats by orally. At the end of the study, superoxide dismutase (SOD) and catalase activities, malondialdehyde (MD A) and glutathione (GSH) levels of the rats' skin tissues were determined. Catalase and SOD activities and GSH levels of all groups were significantly lower than Group I (p<0.05). MDA levels of all groups were significantly higher than Group I (p<0.05). Catalase and SOD activities and GSH levels of Group IV and V were significantly lower than Group II (p<0.05). MDA levels of Group IV and V were significantly higher than Group II (p<0.05). In conclusion, strontium ranelate treatment in oophorectomized rats has resulted in an increase in oxidative stress in skin tissue and can cause to several skin disorders.

ÖZET Amaç: Yaptığımız bu çalışmada deneysel osteoporoz modeli oluşturulan sıçanlarda, post-menopozal tedavide yaygın olarak kullanılan stronsiyum ranelatın karaciğer, böbrek ve kas dokularındaki paraoksonaz (PON) ve arilesteraz (ARE) enzim aktiviteleri üzerindeki etkisi araştırılmıştır. Gereç ve Yöntem:Bu çalışmada 35 adet dişi Wistar Albino sıçan kullanılmış ve her bir grupta 7 hayvan olacak şekilde 5 gruba ayrılmıştır. Bu gruplar kontrol grubu (Grup I), 3 ay boyunca sadece stronsiyum ranelat uygulanan grup (Grup II), sadece ooferektomi uygulanan grup (Grup III), ooferektomi sonra profilaktik amaçla hemen stronsiyum ranelat tedavisine başlanan grup (Grup IV) ve ooferektomi yapıldıktan 3 ay sonra stronsiyum ranelat tedavisine başlanan grup (Grup V) olarak belirlenmiştir. Tüm gruplardaki hayvanların karaciğer, böbrek ve kas dokuları izole edilerek PON ve ARE aktivitelerine bakılmıştır. PON ve ARE değerleri bakımından gruplar arasındaki istatistiksel farklılıklar ANOVA ve alt grup karşılaştırmalarında Tukey çoklu karşılaştırma testleri kullanılarak değerlendirilmiştir. Bulgular: Yaptığımız çalışmada tüm grupların karaciğer, böbrek ve kas PON ve ARE aktiviteleri kontrol grubuna kıyasla anlamlı ölçüde düşük olduğu tespit edilmiştir (p<0,05). Ayrıca Grup V'in karaciğer PON ve ARE aktivitelerinin Grup II, Grup III ve Grup IV'e göre anlamlı ölçüde yüksek olduğu tespit edilmiştir (p<0,05). Sonuç:Bulunan sonuçlar postmenopozal dönemin ve stronsiyum ranelat kullanımının karaciğer, böbrek ve kas dokularındaki PON ve ARE aktivitelerini azalttığını, dolayısıyla antioksidan sistemi zayıflattığını göstermektedir.Anahtar Kelimeler: Stronsiyum ranelat, ooferektomi, paraoksonaz, arilesteraz ABSTRACT Objective: In this study, we investigated the effect of stronsium ranelat, which is used extensively in the postmenopausal treatment, on paraoxonase and arylesterase in liver, kidney and muscle tissues of experimental osteoporosis rats. Materials and Methods:35 female Wistar Albino female rats were divided into 5 groups (7 animals in each group). Group I was the control group, Group II received only stronsium ranelat, Group III underwent only oophorectomy, Group IV was consisted of rats in which stronsium ranelat treatment was started just after oophorectomy, and Group V consisted of rats in which stronsium ranelat treatment was started 3 months after oophorectomy. Liver, kidney, and muscle tissues of rats belonging to all groups were isolated and then PON and ARE activities were examined. The statistical differences in terms of PON and ARE values were evaluated by using ANOVA and Turkey Multiple Comparison for subgroups.Results: According to results obtained from this study, a statistically significant decrease in PON and ARE activities of liver, kidney and muscle of rats in all groups was determined compared to control group (p<0.05). Furthermore, a statistically significant decrease in PON and ARE activities was detected in Group V compared to Group II, Group III and Group IV (p<0.05). Conclusion:It can be concluded from this study...