Vitamin D binding protein genotype frequency in familial Mediterranean fever patients

Orhan, Ceren; Seyhan, Betül; Baykara, Onur; Yıldız, Mehmet; Kasapçopur, Özgür; Buyru, Nur

doi:10.1080/03009742.2020.1762922

Cited by 3 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Substitution of amino acids in the different isoforms of VDBP, like 1S and 2 isoforms, differ from the 1F isoform by post-translational glycosylation. The deglycosylated form of VDBP can promote activation of macrophages and osteoclasts [99,100]. The differentiation of osteoclasts is induced by macrophage colony-stimulating factor (M-CSF) and the receptor activator of nuclear factor-κB ligand (RANKL).…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Vitamin D Binding Protein (VDBP) and Its Gene Polymorphisms—The Risk of Malignant Tumors and Other Diseases

Rozmus

Ciesielska

Płomiński

et al. 2020

IJMS

View full text Add to dashboard Cite

Vitamin D is an important component of the endocrine system that controls calcium homeostasis and bone mineralization. Because of the very short half-life of free serum vitamin D it is stabilized and transported to target tissues by being bound to the vitamin D binding protein (VDBP). The most common polymorphisms: rs4588 and rs7041 in the vitamin D binding protein gene may correlate with differences in vitamin D status in the serum. This review presents data that relate to the presence of genetic variants in the VDBP gene in correlation with certain diseases, mostly concerning cancers (breast, prostate, pancreatic, lung, colorectal, basal cell carcinoma cancer and cutaneous melanoma) or other related diseases (thyroid autoimmunity disorders, obesity, diabetes mellitus, bone metabolism, rheumatoid arthritis, ankylosing spondylitis, asthma, chronic obstructive pulmonary disease, tuberculosis and coronary artery diseases).

show abstract

Section: Rheumatoid Arthritismentioning

confidence: 99%

Vitamin D Binding Protein (VDBP) and Its Gene Polymorphisms—The Risk of Malignant Tumors and Other Diseases

Rozmus

Ciesielska

Płomiński

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…A trial on 107 FMF patients (52 without any MEFV mutation) and 25 healthy individuals, analyzed the VDBP rs4588 and rs7041 polymorphisms, resulting in the identifications of six genotypes. Allelic variant 2 was significantly more frequent in the subgroup of FMF patients MEFV(-) than in healthy controls ( p = 0.001) and the carriers also had a higher risk of development of amyloidosis or arthritis ( p = 0.026) than other FMF patients into the same group [ 11 ]. This effect may be a consequence of the dysregulation of vitamin D levels and the impairment of its immunomodulatory and anti-inflammatory actions.…”

Section: Introductionmentioning

confidence: 99%

Amyloidosis and Glomerular Diseases in Familial Mediterranean Fever

et al. 2021

View full text Add to dashboard Cite

Familial Mediterranean fever (FMF) is a genetic autoinflammatory disease with autosomal recessive transmission, characterized by periodic fever attacks with self-limited serositis. Secondary amyloidosis due to amyloid A renal deposition represents the most fearsome complication in up to 8.6% of patients. Amyloidosis A typically reveals a nephrotic syndrome with a rapid progression to end-stage kidney disease still. It may also involve the cardiovascular system, the gastrointestinal tract and the central nervous system. Other glomerulonephritis may equally affect FMF patients, including vasculitis such as IgA vasculitis and polyarteritis nodosa. A differential diagnosis among different primary and secondary causes of nephrotic syndrome is mandatory to determine the right therapeutic choice for the patients. Early detection of microalbuminuria is the first signal of kidney impairment in FMF, but new markers such as Neutrophil Gelatinase-Associated Lipocalin (NGAL) may radically change renal outcomes. Serum amyloid A protein (SAA) is currently considered a reliable indicator of subclinical inflammation and compliance to therapy. According to new evidence, SAA may also have an active pathogenic role in the regulation of NALP3 inflammasome activity as well as being a predictor of the clinical course of AA amyloidosis. Beyond colchicine, new monoclonal antibodies such as IL-1 inhibitors anakinra and canakinumab, and anti-IL-6 tocilizumab may represent a key in optimizing FMF treatment and prevention or control of AA amyloidosis.

show abstract

Relationship of serum vitamin D, D-dimer and uric acid levels with attacks in children with familial Mediterranean fever

Ates¹,

Sazak²,

Türkmenoğlu³

et al. 2022

The Egyptian Rheumatologist

View full text Add to dashboard Cite

Vitamin D binding protein genotype frequency in familial Mediterranean fever patients

Cited by 3 publications

References 25 publications

Vitamin D Binding Protein (VDBP) and Its Gene Polymorphisms—The Risk of Malignant Tumors and Other Diseases

Vitamin D Binding Protein (VDBP) and Its Gene Polymorphisms—The Risk of Malignant Tumors and Other Diseases

Amyloidosis and Glomerular Diseases in Familial Mediterranean Fever

Relationship of serum vitamin D, D-dimer and uric acid levels with attacks in children with familial Mediterranean fever

Contact Info

Product

Resources

About