Vitamin D and type 2 diabetes mellitus: Where do we stand?

Cavalier, Étienne; Souberbielle, Jean‐Claude; Radermecker, Régis

doi:10.1016/j.diabet.2011.01.001

Cited by 43 publications

(31 citation statements)

References 55 publications

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“…Various cross-sectional studies have largely, but not consistently, shown a significantly increased risk of type 2 diabetes and impaired glucose metabolism in vitamin D deficiency conditions [53,54]. In the same manner, Oosterwerff et al [55] suggested that subjects with serum 25(OH)D below 50 nmol/l, in community-dwelling older persons in The Netherlands, have a higher risk of the metabolic syndrome.…”

Section: Role Of Vitamin D In Insulin Resistancementioning

confidence: 82%

Vitamin D Deficiency: A New Risk Factor for Type 2 Diabetes

et al. 2012

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Recent compelling evidence suggests a role of vitamin D deficiency in the pathogenesis of insulin resistance and insulin secretion derangements, with a consequent possible interference with type 2 diabetes mellitus. The mechanism of this link is incompletely understood. In fact, vitamin D deficiency is usually detected in obesity in which insulin resistance is also a common finding. The coexistence of insulin resistance and vitamin D deficiency has generated several hypotheses. Some cross-sectional and prospective studies have suggested that vitamin D deficiency may play a role in worsening insulin resistance; others have identified obesity as a risk factor predisposing individuals to exhibit both vitamin D deficiency and insulin resistance. The available data from intervention studies are largely confounded, and inadequate considerations of seasonal effects on 25(OH)D concentrations are also a common design flaw in many studies. On the contrary, there is strong evidence that obesity might cause both vitamin D deficiency and insulin resistance, leaving open the possibility that vitamin D and diabetes are not related at all. Although it might seem premature to draw firm conclusions on the role of vitamin D supplementation in reducing insulin resistance and preventing type 2 diabetes, this manuscript will review the circumstances leading to vitamin D deficiency and how such a deficiency can eventually independently affect insulin sensitivity.

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Section: Role Of Vitamin D In Insulin Resistancementioning

confidence: 82%

Vitamin D Deficiency: A New Risk Factor for Type 2 Diabetes

et al. 2012

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“…Earlier studies suggested a signiicantly higher risk of T2DM in Vit D-deicient patients [19,20]. In contrast, Hidayat et al [21] observed no signiicant association between the incidence of T2DM and Vit D deiciency in an older population.…”

Section: Introductionmentioning

confidence: 94%

Vitamin Deficiency Among the Elderly Institutionalized Patients

Alhamad¹,

Nadukkandiyil²,

Sulaiti³

2017

A Critical Evaluation of Vitamin D - Clinical Overview

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Objectives: Deiciency in vitamin D (Vit D) is usually associated with elderly patients. This chapter investigates its prevalence amongst the elderly in long-term care in Qatar. Methodology:The research material included patient chart reviews, electronic data and other evidence-based research papers collated between April 2010 and April 2012. Geriatric patients 65 years and above in healthcare facilities in Qatar were considered as the sample group in this study; its results were analysed and compared, in order of diagnosed Vit D deiciency severity. Results:The total number of patients studied was 889; 66% were female and 34% male, with an average age of 75 ± 8.7 years. The Vit D serum level mean baseline utilized was 24.4 ± 13.5 ng/ml; 72% of patients had Vit D deiciency with 31 and 30% being mildly and moderately deicient, respectively, while approximately 11% were severely deicient. A positive link was identiied between HDL-C and Vit D levels r < 0.17, P < 0.001; however, HbA1c levels showed a negative link with Vit D r < 0.15, P < 0.009. Conclusions:Vit D deiciency was found to be substantially high (72%) among the elderly in Qatar. This low level of Vit D was associated with higher HbA1c and lower HDL-C levels.

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“…On the basis of evidence from small intervention trials or post hoc analyses of trials, they concluded that it was difficult to be definite whether or not vitamin D and/or calcium were important in the prevention of T2DM, and that effects might only be manifest in people who were particularly at risk of T2DM. Other authors have implicated Vitamin D deficiency/insufficiency in the pathogenesis of insulin resistance, pre-diabetes, T2DM, and PCOS (Cavalier et al, 2011;Wehr et al, 2011). Rashidi et al reported that supplementation of just 400 IU daily of Vitamin D increased the ovulation rate significantly when added to 1500 mg/day of metformin (Rashidi et al, 2009).…”

Section: Vitamin D Pilot Studiesmentioning

confidence: 99%