Vitamin D and the Immune System in Menopause: A Review

Min, Jaeyoung; Jo, Hagyeong; Chung, Youn‐Jee; Song, Jae Yen; Kim, Min Jeong; Kim, Mee‐Ran

doi:10.6118/jmm.21011

Cited by 4 publications

(1 citation statement)

References 56 publications

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“…This contributes to the inflammatory process and hormone release, such as estrogen ( Lahita, 2023 ). By contrast, menopause has a negative impact on immune function and is associated with an increased susceptibility of menopausal women to autoimmune disorders ( Min et al, 2021 ). There is also evidence that hormone intervention can help restore the situation.…”

Section: Sex and Immune Responsementioning

confidence: 99%

Sex and gender affect immune aging

Calabrò,

Accardi,

Aiello

et al. 2023

Front. Aging

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The proposed review aims to elucidate the intricate interplay between biological factors (sex differences) and socially constructed factors (gender differences) in the context of immune aging. While the influence of biological differences between men and women on various aspects of immune responses has long been recognized, it is crucial to acknowledge that gender, encompassing the social and cultural roles and expectations associated with being male or female, also significantly shapes these processes. Gender can either accelerate immune aging or promote longevity. By recognizing the impact of both biological and social factors, this work seeks to offer a comprehensive understanding of why men and women may experience divergent trajectories in immune aging and varying outcomes in terms of longevity. Discrepancies in perceived roles of the sexes, both within families and at work, contribute to differing patterns of antigen exposure. Additionally, variations in micronutrient intake and access to preventive healthcare facilities may exist. Health promotion knowledge often correlates with educational attainment, which is unequally represented between males and females in many cultures and across generations in the Western world. In countries without a universal healthcare system, access to healthcare relies on family prioritization strategies to cope with economic constraints, potentially limiting access to specific treatments and affecting immune responses negatively. As a result, both biological factors and social and behavioral factors associated with gender contribute to disparities in immune responses, susceptibility to infections, autoimmune diseases, and vaccine responses among older individuals. However, as demonstrated by the COVID-19 pandemic, older females exhibit greater resilience to infections than older males. Given the crucial role of the immune system in achieving longevity, it is not surprising that women live longer than men, and the number of female centenarians surpasses that of male centenarians.

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Section: Sex and Immune Responsementioning

confidence: 99%

Sex and gender affect immune aging

Calabrò,

Accardi,

Aiello

et al. 2023

Front. Aging

View full text Add to dashboard Cite

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Vitamin D3 affects the gut microbiota in an LPS-stimulated systemic inflammation mouse model

et al. 2023

Microbes and Infection

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The use of vitamin D for patients with inflammatory bowel diseases

Matias

Lima

Nutels

et al. 2024

International Journal for Vitamin and Nutrition Research

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Abstract. As Vitamin D (VD) plays an essential role in Inflammatory Bowel Diseases, this systematic review aimed to update the participation of this vitamin in the prevention or remission of these diseases. This review has included studies in MEDLINE–PubMed, EMBASE, and Cochrane databases. The authors have followed PRISMA (Preferred Reporting Items for a Systematic Review and Meta-analysis) guidelines. According to the inclusion and exclusion criteria, twenty-two randomized clinical trials were selected. In all, 1,209 patients were included in this systematic review: 1034 received only VD and 175 received VD in combination with calcium. The average doses of VD supplementation were from oral 400 IU daily to 10,000 IU per kilogram of body weight. Single injection of 300,000 IU of VD was also used. Several studies have shown the crucial role that VD plays in the therapeutic approach of IBD due to its effects on the immune system. It effectively decreased inflammatory cytokines such as TNF-α and IFN-γ (p<0.05) and provided a reduction in disease activity assessed through different scores such as Crohn’s Disease Activity Index (CDAI) (p<0.05) and Ulcerative Colitis Disease Activity Index (UCDAI) (p<0.05). Unfortunately, the available clinical trials do not have standardization of doses and routes of administration. Existing meta-analyses are biased because they compare studies using different doses or treatments in combination with different drugs or supplements such as calcium. Even though VD has crucial effects on inflammatory processes, there is still a need for standardized studies to establish how the supplementation should be performed and the doses to be administered.

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Vitamin D and the Immune System in Menopause: A Review

Cited by 4 publications

References 56 publications

Sex and gender affect immune aging

Sex and gender affect immune aging

Vitamin D3 affects the gut microbiota in an LPS-stimulated systemic inflammation mouse model

The use of vitamin D for patients with inflammatory bowel diseases

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