Vitamin D3 affects the gut microbiota in an LPS-stimulated systemic inflammation mouse model

Li, Yanning; Si, Hongbo; Ma, Yujie; Li, Shuang; Gao, Lijie; Liu, Kun; Liu, Xifu

doi:10.1016/j.micinf.2023.105180

Cited by 6 publications

(2 citation statements)

References 44 publications

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“…Moreover, because of the sunburn concern, individuals with hypomelanotic disorders may try to avoid sun exposure, resulting in a reduction in endogenous production of active vitamin D in the body. Vitamin deficiency has been linked to inflammatory disorders ( 90 ). This assumption is also supported by several observations: (a) serum vitamin D levels are negatively correlated with levels of inflammatory markers (C-reactive protein, calprotectin, and fibrinogen) and disease severity in individuals with either Crohn’s disease or ulcerative colitis ( 91 ); (b) supplement of vitamin D lowers levels of proinflammatory cytokines in vitro and in vivo ( 92 , 93 ).…”

Section: Link Between Dermatoses and Asdmentioning

confidence: 99%

Link between the skin and autism spectrum disorder

Man,

Yang,

Mauro

et al. 2023

Front. Psychiatry

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Autism spectrum disorder (ASD) is a common neurological disorder. Although the etiologies of ASD have been widely speculated, evidence also supports the pathogenic role of cutaneous inflammation in autism. The prevalence of ASD is higher in individuals with inflammatory dermatoses than in those without inflammatory diseases. Anti-inflammation therapy alleviates symptoms of ASD. Recent studies suggest a link between epidermal dysfunction and ASD. In the murine model, mice with ASD display epidermal dysfunction, accompanied by increased expression levels of proinflammatory cytokines in both the skin and the brain. Children with ASD, which develops in their early lifetime, also exhibit altered epidermal function. Interestingly, improvement in epidermal function alleviates some symptoms of ASD. This line of evidence suggests a pathogenic role of cutaneous dysfunction in ASD. Either an improvement in epidermal function or effective treatment of inflammatory dermatoses can be an alternative approach to the management of ASD. We summarize here the current evidence of the association between the skin and ASD.

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Section: Link Between Dermatoses and Asdmentioning

confidence: 99%

Link between the skin and autism spectrum disorder

Man,

Yang,

Mauro

et al. 2023

Front. Psychiatry

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“…Recent research demonstrates a decline in Eubacterium brachy population following nine weeks on a diet rich in fats(Pessoa et al 2023), yet the connection between such a diet, Eubacterium brachy levels, and constipation remains undetermined. Moreover, a reduction in Eubacterium brachy has been noted in cases of in ammatory bowel disease(Li et al 2023), which implies that Eubacterium brachy may exert a bene cial effect on intestinal health. Signi cantly, the modulation of constipation by Eubacterium brachy appears to be linked to the production of its metabolites known as SCFAs.…”

mentioning

confidence: 99%

The causal relationship between Eubacterium and constipation: a Mendelian randomization study

Fan,

Zhang,

Liu

et al. 2024

Preprint

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Background: Constipation may be related to an imbalance in flora imbalance. In this study, univariate and multivariate Mendelian randomization (MR) studies were used to further understand the causal relationship between different members of genus Eubacteriumand constipation. Methods: The constipation and genus Eubacterium datasets were obtained from the Integrative Epidemiology Unit (IEU) Open Genome-Wide Association Study (GWAS) database. The causal effects between constipation and genus Eubacterium were analyzed using MR-Egger, Weighted median, Simple mode, Weighted mode and Inverse variance weighted (IVW). In univariate MR analysis (UVMR), genus Eubacillus was the exposure factor, constipation was the outcome. In addition, the reliability of UVMR analysis was assessed by sensitivity analyses (heterogeneity tests, horizontal pleiotropy tests and leave-one-out (LOO) analysis). Finally, the MVMR analysis was performed. Results: In the UVMR analysis, genus Eubacterium rectale group id.14374 (p=0.043, OR=0.805) and genus Eubacterium brachy group id.11296 (p=0.036, OR=0.904) were all protective factors on constipation. The results of sensitivity analysis showed that UVMR analysis was reliable. In the MVMR analysis, genus Eubacterium rectalegroup was still a significant protective factor (p=0.007, OR=0.80), while genus Eubacterium brachy group was not a significant protective factor for constipation (p=0.151, OR=0.94) . Conclusion: The results of study supported that genus Eubacterium rectale group had a significant causal relationship with constipation, and the increase of genus Eubacterium rectale group could reduce the risk of constipation.

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D-beta-hydroxybutyrate up-regulates Claudin-1 and alleviates the intestinal hyperpermeability in lipopolysaccharide-treated mice

Wang,

Zhuang,

et al. 2024

Tissue and Cell

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Vitamin D3 affects the gut microbiota in an LPS-stimulated systemic inflammation mouse model

Cited by 6 publications

References 44 publications

Link between the skin and autism spectrum disorder

Link between the skin and autism spectrum disorder

The causal relationship between Eubacterium and constipation: a Mendelian randomization study

D-beta-hydroxybutyrate up-regulates Claudin-1 and alleviates the intestinal hyperpermeability in lipopolysaccharide-treated mice

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