Vitamin D and the Central Nervous System: Development, Protection, and Disease

Roman, Samantha; Mowry, Ellen M.

doi:10.1007/978-3-319-73742-3_12

Cited by 3 publications

(4 citation statements)

References 128 publications

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“…Vitamin E (alpha-tocopherol, tocopherol, and tocotrienol) is a fat-soluble essential vitamin that mainly enters the human body from food (Table 2) [67]. In the gastrointestinal tract, tocopherol is hydrolyzed by lipase and esterase.…”

Section: Vitamin Ementioning

confidence: 99%

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Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis

Goncharova

Davydova²,

Попова³

et al. 2021

Nutrients

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Amyotrophic lateral sclerosis (ALS) is an incurable chronic progressive neurodegenerative disease with the progressive degeneration of motor neurons in the motor cortex and lower motor neurons in the spinal cord and the brain stem. The etiology and pathogenesis of ALS are being actively studied, but there is still no single concept. The study of ALS risk factors can help to understand the mechanism of this disease development and, possibly, slow down the rate of its progression in patients and also reduce the risk of its development in people with a predisposition toward familial ALS. The interest of researchers and clinicians in the protective role of nutrients in the development of ALS has been increasing in recent years. However, the role of some of them is not well-understood or disputed. The objective of this review is to analyze studies on the role of nutrients as environmental factors affecting the risk of developing ALS and the rate of motor neuron degeneration progression. Methods: We searched the PubMed, Springer, Clinical keys, Google Scholar, and E-Library databases for publications using keywords and their combinations. We analyzed all the available studies published in 2010–2020. Discussion: We analyzed 39 studies, including randomized clinical trials, clinical cases, and meta-analyses, involving ALS patients and studies on animal models of ALS. This review demonstrated that the following vitamins are the most significant protectors of ALS development: vitamin B12, vitamin E > vitamin C > vitamin B1, vitamin B9 > vitamin D > vitamin B2, vitamin B6 > vitamin A, and vitamin B7. In addition, this review indicates that the role of foods with a high content of cholesterol, polyunsaturated fatty acids, urates, and purines plays a big part in ALS development. Conclusion: The inclusion of vitamins and a ketogenic diet in disease-modifying ALS therapy can reduce the progression rate of motor neuron degeneration and slow the rate of disease progression, but the approach to nutrient selection must be personalized. The roles of vitamins C, D, and B7 as ALS protectors need further study.

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Section: Vitamin Ementioning

confidence: 99%

“…It has been shown that eight substances have an activity of vitamin E: alpha-, beta-, gamma-, and delta-tocopherol and alpha-, beta-, gamma-, and delta-tocotrienol. However, more often, the synonym for alpha-tocopherol is used to denote the term vitamin E [67].…”

Section: Vitamin Ementioning

confidence: 99%

Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis

Goncharova

Davydova²,

Попова³

et al. 2021

Nutrients

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show abstract

“…Vitamin D is a fat-soluble vitamin and is an essential nutrient for the body [6], which plays an important role in the health and survival of humans [7]. Several studies have focused on its role in the prevention of diseases such as heart disease [8], inflammatory bowel disease [9], multiple sclerosis [10], rheumatoid arthritis [11], Immune system diseases [12], diabetes [13] and infectious diseases [14]. Vitamin D deficiency worldwide is probably due to limited sun exposure and insufficient intake of vitamin D from the diet [15].…”

Section: Introductionmentioning

confidence: 99%

Association of health literacy and nutritional literacy with sun exposure in adults using structural equation modelling

et al. 2022

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Background Inadequate health and nutritional literacy is a common problem among adults, associated with poor health outcomes. Therefore, this study aimed to investigate the relationship between health literacy and nutritional literacy to sun exposure behaviour. Methods We conducted a cross-sectional study on 261 adults (18–65 years) in Iran. Data was collected on knowledge, motivation, health literacy, nutritional literacy, and sun exposure behaviour using an interview-assisted questionnaire. Using the information–motivation–behavioural skills model and structural equation modeling, we tested whether health and nutritional literacy were associated with the relationships between knowledge of vitamin D, attitudes toward sun exposure, and sun exposure behaviour. Different models using structural equation modeling were performed to analyze the data. Results The finding showed that health literacy (β = 0.29, p < 0.001) and nutritional literacy (β = 0.14, p = 0.02) was directly associated with sunlight exposure. Indirect relationships also existed between knowledge and sunlight exposure through health literacy (β = 0.33, p < 0.001) and nutritional literacy (β = 0.22, p = 0.01). The model had good fit (x2/df = 1.422; RMSEA = 0.040; CFI = 0.851; NFI = 0.657). There was no significant relationship between health literacy and motivation (β = 0.11, p = 0.16), nutritional literacy and motivation (β = 0.06, p = 0.42) and motivation and sun exposure (β = 0.01, p = 0.91). Conclusions The findings showed that individuals with sufficient health literacy and nutritional literacy were more likely to have exposure to sunlight. Health and nutritional literacy should be considered when educating adults about vitamin D supplements and sunlight exposure.

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“…Vitamin D is a fat soluble vitamin, and is an essential nutrient for the body [6], which plays an important role in the health and survival of humans [7]. Several studies have focused on its role in the prevention of diseases such as heart disease [8], in ammatory bowel disease [9], multiple sclerosis [10], rheumatoid arthritis [11], Immune system diseases [12], diabetes [13] and infectious diseases [14]. Vitamin D de ciency around the world is probably due to limited sun exposure and insu cient intake of vitamin D from the diet [15].…”

Section: Introductionmentioning

confidence: 99%

Association of health and nutritional literacy with sun exposure in adults using structural equation modelling

SaeidiFard

mehrizi

Akbarzadeh

et al. 2021

Preprint

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Background: Inadequate health and nutritional literacy is a common problem among adults which is associated with poor health outcomes. Therefore, this study aimed to investigate the relationship between health and nutritional literacy to sun exposure behavior. Methods: We conducted a cross-sectional study on 261 adults (18-65 years) in Iran. Knowledge, motivation, health literacy, nutritional literacy and sun exposure behavior using an interview-assisted questionnaire was evaluated. Using the information–motivation–behavioral skills model and structural equation modeling, we tested whether health and nutritional literacy was associated with the complex relationships among knowledge of vitamin D, attitudes toward sun exposure and sun exposure behavior. Beta and p values were calculated.Results: Health literacy (β= 0.29, p<0.001) and nutritional literacy (β= 0.14, p=0.02) was directly associated with sunlight exposure. Indirect relationships also existed between knowledge and sunlight exposure through health literacy (β = 0.33, p<0.001) and nutritional literacy (β = 0.22, p=0.01). The model had good fit (x2/df = 1.422; RMSEA = 0.040; CFI = 0.851; NFI = 0.657). There were no significant relationship between health literacy and motivation (β = 0.11, p=0.16), nutritional literacy and motivation (β = 0.06, p=0.42) and motivation and sun exposure (β = 0.01, p=0.91). Conclusions: Our findings showed that individuals with sufficient health and nutritional literacy more likely to have exposure to sunlight. Health and nutritional literacy should be considered when educating adults about vitamin D supplements and sunlight exposure.

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Vitamin D and the Central Nervous System: Development, Protection, and Disease

Cited by 3 publications

References 128 publications

Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis

Nutrient Effects on Motor Neurons and the Risk of Amyotrophic Lateral Sclerosis

Association of health literacy and nutritional literacy with sun exposure in adults using structural equation modelling

Association of health and nutritional literacy with sun exposure in adults using structural equation modelling

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