Vitamin D and skin cancer: A meta-analysis

Gandini, Sara; Raimondi, Sara; Gnagnarella, Patrizia; Doré, Jean; Maisonneuve, Patrick; Testori, Alessandro

doi:10.1016/j.ejca.2008.10.003

Cited by 122 publications

(106 citation statements)

References 49 publications

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“…One study previously reported a comprehensive bibliographic search of the literature that identified studies on cutaneous malignant melanomas and non-melanomas, vitamin D receptor polymorphisms, vitamin D intake and 25(OH) D serum levels. An association was found for two types of polymorphisms and melanoma (42). It can be concluded from these studies that there is a direct correlation between NMSC rates and mortality with UVB radiation, meaning that this type of cancer would not depend on vitamin D synthesis and therefore on calcium uptake; by contrast, MSC rates increased with decreased levels of vitamin D and thus calcium uptake in all cities, with the only exception being Punta Arenas.…”

Section: Discussionmentioning

confidence: 73%

Association between non-melanoma and melanoma skin cancer rates, vitamin D and latitude

et al. 2017

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Abstract. Vitamin D synthesis takes place in the skin due to solar ultraviolet-B (UVB) radiation. Several studies have shown the association between low sun exposure, non-melanoma skin cancer (NMSC) and a lack of vitamin D synthesis. Since such synthesis in the body depends on the exposure of the skin to solar UVB radiation (290-320 nm), experimental measurements of this type of solar radiation are important. Tarapaca University in Arica, Chile, established a solar UV radiation laboratory in 2006 and since then this laboratory has performed systematic experimental solar UVB measurements using a calibrated biometer instrument. The results, which are presented in the current study, showed the association between NMSC and MSC rates, and the time required to produce 1,000 IU vitamin D with latitudinal variation. Solar UV index (UVI) levels reported in 6 cities from the north to the south of Chile indicated that the UVI ratio of monthly mean values was 1.8 times higher in Arica than in Punta Arenas in January (summer in Chile), whereas it was 14 times higher in June (winter). This factor is an important consideration, since vitamin D synthesis is directly associated with the exposure of individuals to solar UVB radiation. A similar trend was observed in Antofagasta, Santiago, Concepcion, Valdivia and Punta Arenas. It can be concluded from these data that there is a direct association between NMSC rates and mortality, and UVB radiation, meaning that this type of cancer would not depend on vitamin D synthesis and therefore on calcium uptake. By contrast, MSC rates increased with decreased levels of vitamin D, and thus calcium uptake, in all cities, with the only exception being Punta Arenas.

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Section: Discussionmentioning

confidence: 73%

Association between non-melanoma and melanoma skin cancer rates, vitamin D and latitude

et al. 2017

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“…Moreover, these differences might also result from confounding factors that are taken into consideration in these studies and include food habits, age, education, menopausal status, parity, body-mass index, use of oral contraceptives or hormone replacement therapy, tubal ligation, and others (Lurie et al, 2007(Lurie et al, , 2011Tworoger et al, 2009). The BsmI or FokI SNPs in VDR have been associated with breast, bladder, renal, carcinoma, and cutaneous malignant melanoma and nonmelanoma skin cancer (Mittal et al, 2007;Gandini et al, 2009;Tang et al, 2009;Arjumand et al, 2012). These polymorphisms were also recognized as risk factors of hepatocellular, head and neck, thyroid, prostate, and colorectal cancers (Liu et al, 2005;Mishra et al, 2005;Bai et al, 2009Bai et al, , 2012Penna-Martinez et al, 2009;Falleti et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Receptor Gene BsmI and FokI Polymorphisms in Relation to Ovarian Cancer Risk in the Polish Population

Mostowska

Sajdak²,

Pawlik³

et al. 2013

Genetic Testing and Molecular Biomarkers

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Background: The role of vitamin D receptor (VDR) single-nucleotide polymorphisms (SNPs) in ovarian cancer has been studied in various populations; however, these results are discordant between different ethnicities. Method: Using the polymerase chain reaction-restriction fragment length polymorphism method, we studied the prevalence of the VDR FokI (rs2228570) and BsmI (rs1544410) SNPs in women with ovarian cancer (n = 168) and controls (n = 182) in a Polish population.

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“…Notwithstanding, only few reviews are actually available about the risk for CMM in relation to diet; moreover, some of these are specifically focused on particular nutrients, i.e. vitamin D, while some are related to all cutaneous disorders and not specifically to CMM [19,[29][30][31]. Furthermore, it is important to underline that results of existing studies are unclear, controversial and often inconsistent [32].…”

Section: Funding: Nonementioning

confidence: 99%

Systematic review of studies investigating the association between dietary habits and cutaneous malignant melanoma

et al. 2015

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ObjectiveSeveral papers have dealt with diet as a risk factor for cutaneous malignant melanoma (CMM). This study is aimed at synthesizing available data on the topic. Study designA systematic review of observational studies assessing the association between dietary habits and CMM was performed. MethodsElectronic databases were used to identify eligible articles. Quality was evaluated through the NewCastle Ottawa scale. Case control and cohort studies assessing CMM occurrence in people with highest level of food and nutrient intake in comparison to lowest were considered eligible. Data from single studies were described qualitatively because combination of data was not possible. ResultsSixteen articles were selected. Cohort studies showed a better quality than case-control ones. Most studies did not figure out any significant association between foods intake and CMM, except for few evidence of a protective role associated to fish, vegetables and fruit. Risk reduction was shown 35-37%, 40-57% and 34-46% respectively across studies releasing significant results. Beta-carotene, vitamin A, retinol, vitamin E, and vitamin D showed a protective role in single studies with a risk reduction of 64%, 49%, 37-43%, 50-66% and 39% respectively. Conclusion 4A trend in the reduction of CMM risk with higher intake of fish, vegetables and fruits, as well as beta-carotene and vitamins A, E and D has been shown but further research is needed to provide decisive data.

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Vitamin D and skin cancer: A meta-analysis

Cited by 122 publications

References 49 publications

Association between non-melanoma and melanoma skin cancer rates, vitamin D and latitude

Association between non-melanoma and melanoma skin cancer rates, vitamin D and latitude

Vitamin D Receptor Gene BsmI and FokI Polymorphisms in Relation to Ovarian Cancer Risk in the Polish Population

Systematic review of studies investigating the association between dietary habits and cutaneous malignant melanoma

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