Vitamin D and risk of death from vascular and non-vascular causes in the Whitehall study and meta-analyses of 12 000 deaths

Tomson, Joseph; Emberson, Jonathan; Hill, Michael; Gordon, Andrew C.; Armitage, Jane; Shipley, Martin J.; Collins, Rory; Clarke, Robert

doi:10.1093/eurheartj/ehs426

Cited by 93 publications

(76 citation statements)

References 32 publications

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“…A partir de esa fecha, un número grande de estudios han informado que las concentraciones adecuadas de 25(OH)D se asocian con menor prevalencia de diabetes, hipertensión, dislipidemia y síndrome metabólico [6][7][8][9] . Por otra parte, se ha reportado asociación de la deficiencia de 25(OH)D con mayor prevalencia de EAC asintomática 10 y con eventos cardiovasculares como infarto del miocardio 11 y mortalidad de causa cardiovascular y no vascular 12 . Sin embargo, existen varios estudios que no han encontrado asociación entre la deficiencia de esta vitamina y la enfermedad cardiovascular 13,14 .…”

Section: Introductionunclassified

Deficiencia de vitamina D y su asociación con enfermedad arterial coronaria en población mexicana: estudio Genético de la Enfermedad Aterosclerosa

López-Bautista¹,

Posadas‐Romero²,

Cardoso-Saldaña³

et al. 2017

GMM

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Section: Introductionunclassified

Deficiencia de vitamina D y su asociación con enfermedad arterial coronaria en población mexicana: estudio Genético de la Enfermedad Aterosclerosa

López-Bautista¹,

Posadas‐Romero²,

Cardoso-Saldaña³

et al. 2017

GMM

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“…A growing literature (1)(2)(3) suggests that vitamin D may be associated with reduced mortality (overall (4) and hospital-associated (5) ), incidence of cancer (6)(7)(8)(9)(10)(11)(12)(13) , CVD (14,15) , diabetes (16) , fractures (17,18) and ageing-related functional limitations (19) , although some studies find an unclear relationship (20,21) or a harmful association with disease (22) . Randomized controlled trials are underway to examine the potential role of vitamin D in the prevention of multiple diseases, including cancer, CVD and diabetes (20,23) .…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency in minority populations

Taksler

Cutler

Giovannucci

et al. 2014

Public Health Nutr.

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Objective: Black and Hispanic individuals synthesize less vitamin D per unit of sun exposure than white individuals. The relationship between UV radiation and vitamin D insufficiency in minorities has not been well explored. Design: Prospective cohort study. Setting: Using the National Health and Nutrition Examination Survey, we obtained serum vitamin D levels for non-Hispanic Whites, Hispanics and non-Hispanic Blacks aged ≥18 years from [2000][2001][2002][2003][2004][2005][2006]. We linked these data with the average monthly solar UV index by census tract and data on sun exposure, vitamin D supplementation, health and demographics. We used multivariable regression analyses to assess vitamin D deficiency (<15 ng/ml) and insufficiency (<20 ng/ml) in January (when the UV index was lowest) by race/ethnicity and geography. Subjects: Adults (n 14 319) aged ≥18 years. Results: A 1-point increase in the UV index was associated with a 0·51 ng/ml increase in vitamin D (95 % CI 0·35, 0·67 ng/ml; P < 0·001). Non-Hispanic Black race and Hispanic ethnicity were associated with a 7·47 and 3·41 ng/ml decrease in vitamin D, respectively (both P < 0·001). In January, an estimated 65·4 % of nonHispanic Blacks were deficient in vitamin D, compared with 28·9 % of Hispanics and 14·0 % of non-Hispanic Whites. An estimated 84·2 % of non-Hispanic Blacks were insufficient in vitamin D v. 56·3 % of Hispanics and 34·8 % of non-Hispanic Whites. More non-Hispanic Blacks were estimated to be deficient in vitamin D in January in the highest UV index quartile than were non-Hispanic Whites in the lowest UV index quartile (60·2 % v. 25·7 %). Conclusions: Wintertime vitamin D insufficiency is pervasive among minority populations, and not uncommon among non-Hispanic Whites. KeywordsVitamins Vitamin D Disparities Race SurvivalThe Institute of Medicine estimates that 54 % of non-Hispanic Blacks have very low levels of vitamin D (25-hydroxycholecalifierol (25(OH)D 3 ) < 16 ng/ml), v. 27 % of Mexican Americans and 11 % of non-Hispanic Whites (1,2) . A growing literature (1)(2)(3) suggests that vitamin D may be associated with reduced mortality (overall (4) and hospital-associated (5) ), incidence of cancer (6)(7)(8)(9)(10)(11)(12)(13) , CVD (14,15) , diabetes (16) , fractures (17,18) and ageing-related functional limitations (19) , although some studies find an unclear relationship (20,21) or a harmful association with disease (22) . Randomized controlled trials are underway to examine the potential role of vitamin D in the prevention of multiple diseases, including cancer, CVD and diabetes (20,23) .There are known racial and seasonal variations in vitamin D. Black individuals synthesize less vitamin D per unit of sun exposure than white individuals, because darker complexion acts as a natural sunscreen (24,25) .The majority of vitamin D is estimated to derive from sunshine for most people (26) , with the liver converting cholecalciferol into 25(OH)D 3 , the form of vitamin D typically measured in blood serum. 25(OH)D 3 has a reported half-lif...

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“…The Whitehall study conducted a 13-year follow up of approximately 5409 older adults and reported that higher concentration of vitamin D was inversely and linearly correlated with both vascular and nonvascular disease mortality and that doubling of serum vitamin D concentration was associated with significant reduction in the mortality rates. 82 Similarly, the Copenhagen city heart study examined approximately 10,170 Danish adults in 1981-1983 for baseline cardiovascular risk factors and diseases and during a 29 year longitudinal follow up indicated that lower vitamin D level was associated with a 64% higher risk of myocardial infarction, 57% higher risk of premature mortality and 81% higher risk of fatal ischemic heart disease. 83 Thus vitamin D deficiency is associated with significant mortality and morbidity from chronic diseases.…”

Section: Neuropsychiatric Conditionmentioning

confidence: 99%

Vitamin D for Depression with a Seasonal Pattern: an Effective Treatment Strategy

Sarkar¹

2017

IPMRJ

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Vitamin D and risk of death from vascular and non-vascular causes in the Whitehall study and meta-analyses of 12 000 deaths

Abstract: Despite strong inverse and apparently independent associations of 25(OH)D with vascular and non-vascular mortality, causality remains uncertain. Large-scale randomized trials, using high doses of vitamin D, are required to assess the clinical relevance of these associations.

Cited by 93 publications

References 32 publications

Deficiencia de vitamina D y su asociación con enfermedad arterial coronaria en población mexicana: estudio Genético de la Enfermedad Aterosclerosa

Deficiencia de vitamina D y su asociación con enfermedad arterial coronaria en población mexicana: estudio Genético de la Enfermedad Aterosclerosa

Vitamin D deficiency in minority populations

Vitamin D for Depression with a Seasonal Pattern: an Effective Treatment Strategy

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