Vitamin D and risk of ankylosing spondylitis: A two-sample mendelian randomization study

Jiang, Jinjin; Shao, Ming; Wu, Xuezhong

doi:10.1016/j.humimm.2021.09.003

Cited by 12 publications

(7 citation statements)

References 31 publications

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“…Notably, the role of vitamin D has also been inconsistent in studies of its association with other autoimmune diseases. These include compulsory spondylitis [ 45 ], systemic lupus erythematosus [ 46 ], rheumatoid arthritis [ 47 ], and others. In sum, the underlying mechanism behind the relationship between vitamin D and SS is complex and worthy of further investigation.…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin D levels and Sjogren’s syndrome: bi-directional Mendelian randomization analysis

Zeng

Fan

et al. 2023

Arthritis Res Ther

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Background Based on the results of existing observational studies, it can be found that the association between serum vitamin D levels and the risk of Sjogren’s syndrome (SS) in humans is still controversial. Based on this situation, this study aimed to assess the causal relationship between serum vitamin D levels and SS by using the Mendelian randomization (MR) approach. Methods In this study, genome-wide association studies (GWAS) summary statistics on serum vitamin D levels [sample size = 417,580 (UK Biobank)] and SS [sample size = 416,757 (cases = 2495, controls = 414,262) (FinnGen)] were used. The bi-directional MR analysis was then used to assess possible causal relationships. The major analysis method of MR was performed using inverse-variance weighted (IVW), supplemented by MR-Egger and the weighted median approaches. In addition, sensitivity analyses were used to ensure the stability of the results, including Cochran’s Q test, MR-PRESSO, MR-Egger intercept test, and the leave-one-out test. Results The MR suggested that no significant causal effects of serum 25(OH)D levels on SS risks were observed [odds ratio (OR) = 0.9824; 95% confidence interval (CI) = 0.7130 to 1.3538; P = 0.9137]. Similarly, no evidence supported the causal effects of SS on serum vitamin D levels (β: 0.0076, 95% CI: − 0.0031 to 0.0183; P = 0.1640). Conclusion This study found no obvious evidence that serum vitamin D level is causally associated with SS risks or vice versa. We call for larger sample size studies to further unravel the potential causal relationship and the exact mechanism.

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Section: Discussionmentioning

confidence: 99%

Serum vitamin D levels and Sjogren’s syndrome: bi-directional Mendelian randomization analysis

Zeng

Fan

et al. 2023

Arthritis Res Ther

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“…We selected SNPs independent with a genome-wide significance, by following these criteria: First, the selected SNPs were significantly associated with green tea intake based on a genome-wide significance threshold ( p < 5.0 × 10 −8 ); ( 13 ). Second, SNPs in linkage disequilibrium with r 2 < 0.001 and distance >10,000 kb were excluded ( 14 , 15 ).…”

Section: Methodsmentioning

confidence: 99%

Genetically predicted green tea intake and the risk of arterial embolism and thrombosis

et al. 2023

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BackgroundIn previous observational studies, green tea intake has been demonstrated to protect against arterial embolism and thrombosis. However, whether there is a causative connection between green tea intake and arterial embolism and thrombosis is currently unclear.MethodsA two-sample Mendelian randomization (MR) study has been designed to explore whether there is a causal association between green tea intake and arterial embolism and thrombosis by acquiring exposure and outcome data from previously published research. Data from the MRC-IEU (data on green tea intake, 64,949 participants) consortium and the FinnGen project (data on arterial embolism and thrombosis, 278 cases of arterial thrombosis and 92,349 control participants) has been utilized to determine the causal impact of green tea intake on arterial embolism and thrombosis.ResultsWe found that genetically predicted green tea intake was causally associated with a lower risk of arterial embolism and thrombosis (IVW odds ratio [OR] per SD decrease in green tea intake = 0.92 [95% confidence interval, 0.85–0.99]; p = 0.032). Moreover, the sensitivity analysis (both MR Egger regression and weighted median) yielded comparable estimates but with low precision. No directional pleiotropic effect between green tea intake and arterial embolism and thrombosis was observed in both funnel plots and MR-Egger intercepts.ConclusionsOur study provided causal evidence that genetically predicted green tea intake may be a protective factor against arterial embolism and thrombosis.

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“…In a meta-analysis involving eight studies and a total of 533 AS patients, it was found that vitamin D may play a protective role against AS and that a reverse association exists between vitamin D levels and disease activity [ 170 ]. By contrast, an analysis investigating a possible causal role of vitamin D in AS concluded that vitamin D is not causally related to AS [ 171 ].…”

Section: Ankylosing Spondylitis and Vitamin Dmentioning

confidence: 99%

Vitamin D and Autoimmune Rheumatic Diseases

Athanassiou

Kostoglou-Athanassiou

Koutsilieris

et al. 2023

Biomolecules

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Vitamin D is a steroid hormone with potent immune-modulating properties. It has been shown to stimulate innate immunity and induce immune tolerance. Extensive research efforts have shown that vitamin D deficiency may be related to the development of autoimmune diseases. Vitamin D deficiency has been observed in patients with rheumatoid arthritis (RA) and has been shown to be inversely related to disease activity. Moreover, vitamin D deficiency may be implicated in the pathogenesis of the disease. Vitamin D deficiency has also been observed in patients with systemic lupus erythematosus (SLE). It has been found to be inversely related to disease activity and renal involvement. In addition, vitamin D receptor polymorphisms have been studied in SLE. Vitamin D levels have been studied in patients with Sjogren’s syndrome, and vitamin D deficiency may be related to neuropathy and the development of lymphoma in the context of Sjogren’s syndrome. Vitamin D deficiency has been observed in ankylosing spondylitis, psoriatic arthritis (PsA), and idiopathic inflammatory myopathies. Vitamin D deficiency has also been observed in systemic sclerosis. Vitamin D deficiency may be implicated in the pathogenesis of autoimmunity, and it may be administered to prevent autoimmune disease and reduce pain in the context of autoimmune rheumatic disorders.

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Vitamin D and risk of ankylosing spondylitis: A two-sample mendelian randomization study

Cited by 12 publications

References 31 publications

Serum vitamin D levels and Sjogren’s syndrome: bi-directional Mendelian randomization analysis

Serum vitamin D levels and Sjogren’s syndrome: bi-directional Mendelian randomization analysis

Genetically predicted green tea intake and the risk of arterial embolism and thrombosis

Vitamin D and Autoimmune Rheumatic Diseases

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