Genetically predicted green tea intake and the risk of arterial embolism and thrombosis

Abstract

BackgroundIn previous observational studies, green tea intake has been demonstrated to protect against arterial embolism and thrombosis. However, whether there is a causative connection between green tea intake and arterial embolism and thrombosis is currently unclear.MethodsA two-sample Mendelian randomization (MR) study has been designed to explore whether there is a causal association between green tea intake and arterial embolism and thrombosis by acquiring exposure and outcome data from previously published research. Data from the MRC-IEU (data on green tea intake, 64,949 participants) consortium and the FinnGen project (data on arterial embolism and thrombosis, 278 cases of arterial thrombosis and 92,349 control participants) has been utilized to determine the causal impact of green tea intake on arterial embolism and thrombosis.ResultsWe found that genetically predicted green tea intake was causally associated with a lower risk of arterial embolism and thrombosis (IVW odds ratio [OR] per SD decrease in green tea intake = 0.92 [95% confidence interval, 0.85–0.99]; p = 0.032). Moreover, the sensitivity analysis (both MR Egger regression and weighted median) yielded comparable estimates but with low precision. No directional pleiotropic effect between green tea intake and arterial embolism and thrombosis was observed in both funnel plots and MR-Egger intercepts.ConclusionsOur study provided causal evidence that genetically predicted green tea intake may be a protective factor against arterial embolism and thrombosis.

The role of green tea intake in thromboprophylaxis of venous thromboembolism in patients with cancer

“…By contrast, no significant difference of D-dimer change was observed between the two groups. From the clinical perspective of the efficacy of green tea intake on thrombotic diseases, only a study provided causal evidence between genetically predicted green tea intake and the prophylaxis of arterial embolism and thrombosis ( 9 ). The present study is the first one that provides clinical evidence for the prophylactic efficacy of green tea intake in the development of VTE among cancer patients.…”

“…In the green tea group, patients were subdivided into subgroups according to the average volume of green tea they drank per day. Based on the previous literature ( 9 ), all patients in the green tea group were classified into subgroup 1 (0–250 mL per day), subgroup 2 (250–500 mL per day), and subgroup 3 (500 mL or more per day) in the present study, according to the self-reported average volume of green tea that they drank per day. In China, tea brewing is typically conducted by infusing 2–3 grams of loose tea leaves in a cup containing 100–150 mL hot water with a temperature of 85–100°C.…”

“…Epigallocatechin-3-gallate (EGCG), which is the most important component of green tea catechins (GTC) in green tea, has been identified as a potent inhibitor of HSP47 and is proven to be beneficial for the treatment of PE in a murine model ( 8 ). In a two-sample Mendelian randomization study carried out to explore whether there is a causal association between green tea intake and arterial embolism and thrombosis in the MRC-IEU consortium (64,949 participants with green tea intake) and the FinnGen project (278 cases of arterial thrombosis and 92,349 control participants), genetically determined green tea intake was causally associated with a lower risk of arterial embolism and thrombosis ( 9 ). Green tea intake is also considered to have prophylactic and therapeutic efficacy in cancer ( 10 , 11 ).…”

Caffeinated beverages intake and risk of deep vein thrombosis: A Mendelian randomization study

“…A Mendelian randomization study showed that tea consumption can reduce the risk of arterial thrombosis [ 36 ]. Besides, there seems to be a lack of sufficient research on the relationship between tea consumption and DVT.…”