Vitamin D and its Relation to Bone Mineral Density in Postmenopause Women

Labronici, Pedro José; Blunck, Saulo Santos; Lana, Flavius Ribeiro; Esteves, Bruno Bandeira; Franco, José Sergio; Fukuyama, Junji Miller; Pires, Robinson Esteves Santos

doi:10.1016/j.rboe.2012.07.003

Cited by 12 publications

(11 citation statements)

References 37 publications

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“…Though literature widely reports positive association between BMD and Vitamin D [ 56 ], our data set of population uncovered finding of no relationship between the two. However similar findings have been reported by other colleagues too [ [57] , [58] , [59] , [60] ]. The conflicting findings can partially be elucidated by ethnic differences in the populations and wider age groups (20–80 years).…”

Section: Discussionsupporting

confidence: 92%

Prevalence of osteoporosis and osteopenia in an apparently healthy Indian population - a cross-sectional retrospective study

Kaushal

Vohora

Jalali

et al. 2018

Osteoporosis and Sarcopenia

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ObjectivesAn understanding of bone mineral density (BMD) pattern in a population is crucial for prevention and diagnosis of osteoporosis and management of its complications in later life. This study aimed to screen the bone health status and factors associated with osteoporosis in an apparently healthy Indian population.MethodsA retrospective review of medical records was done in a tertiary-care hospital for the subjects who had undergone preventive health-check-ups that included BMD measurements at femur-neck, total-femur, and lumbar-spine.ResultsWe evaluated 524 subjects (age, 50.0 ± 12.4 years) including 41.2% female and 58.8% male subjects. Osteoporosis was present in 6.9% subjects (female, 11.1%; male, 4.2%) and osteopenia in 34% subjects (female, 40.3%; male, 29.9%). Absolute BMD was higher in male subjects (P < 0.001) compared to female subjects at all bone sites. Prevalence of osteoporosis increased with age in female subjects, but not in male subjects. Osteoporosis rates in the age-groups of 30–39, 40–49, 50–59, 60–69, and ≥70 years were 3%, 3.4%, 14.3%, 18.6%, and 36.4%, respectively in female subjects while prevalence in male subjects was 0%, 4%, 6.5%, 4.3%, and 5.6%, respectively, at lumbar spine. Height (r = 0.234–0.358), weight (r = 0.305–0.388), body mass index (r = 0.143–0.285) and physical activity (r = 0.136–0.153) were positively; and alkaline phosphatase (r = −0.133 to −0.203) was negatively correlated with BMD (all P < 0.01) at all sites. These parameters retained significant correlation after controlling for age and sex. No correlation of serum 25-hydroxy-vitamin-D and calcium was noted with BMD (P > 0.05) at any site.ConclusionsFurther data on absolute BMD, T scores, and prevalence rates of osteoporosis/osteopenia on multiple bone sites have been presented in this article.

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Section: Discussionsupporting

confidence: 92%

Prevalence of osteoporosis and osteopenia in an apparently healthy Indian population - a cross-sectional retrospective study

Kaushal

Vohora

Jalali

et al. 2018

Osteoporosis and Sarcopenia

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“…As seen in the results presented above, women were found to have lower levels of VD in both groups of patients, indicating an increased incidence of hypovitaminosis D in the female sex. Many studies have confirmed this fact [24], as women have a gradual decline in postmenopausal VD levels and aging intensifies the hypovitaminosis. A large study with a 90,000-women sample revealed an increased incidence of hypovitaminosis D and increased risk for hip fracture [25].…”

Section: Discussionmentioning

confidence: 86%

Hypovitaminosis D in the Greek Elderly Population Doesn't Concern Only Patients with Hip Fracture

Papaioannou¹,

Πανταζίδου²,

Kostoglou-Athanasiou³

et al. 2020

Cureus

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Introduction Vitamin D (VD) deficiency seems to be an underestimated public health issue, especially in countries with a significant duration of sunlight throughout the year, as in this sunny Mediterranean region where this cross-sectional observational study was held. This study was conducted to assess the hypothesis that a higher prevalence of hypovitaminosis D exists in the elderly population with a hip fracture as compared with patients with knee/hip osteoarthritis or lumbar spondylosis in a southwestern Mediterranean region. Methods This study included 61 consecutive patients with a mean age of 83 years who sustained a hip fracture (Group A). Sixty patients, with an average age of 73 years, who suffered from degenerative hip/knee osteoarthritis or lumbar spondylosis were subsequently selected as the control group (Group B). Parathyroid hormone (PTH) and 25-hydroxy VD blood levels were measured. Results Ninety-six point seven percent (96.7%; 59/61) of the individuals with hip fracture and 81.7% (49/60) in the controls were found with abnormal VD values (<30 ng/ml). The comparison of vitamin D values between the total samples of group A and B revealed a statistically significant difference (unpaired t-test, p<0.0001) while both male (p=0.0049) and female (p<0.0001) individuals in group A also showed statistically significant lower VD levels than their counterparts did. In addition, increased levels of parathormone were observed in women of group A (p=0.0016) and, therefore, for group A in the total sample (p=0.0004) while no statistical significance was observed in males (p=0.7712). Age was found to be an independent risk factor for VD deficiency in both groups (Group A p=0.04, Group B p=0.043). It is noteworthy that only four patients from group B (6, 67%) and none from group A had undergone blood tests for VD and PTH evaluation before hospital admission. Conclusions Τhe results confirmed the initial hypothesis of the study. Although VD hypovitaminosis concerns the majority of elderly living in this southwestern Mediterranean region, the authors suggest VD and PTH measurements regardless of annual insolation, to identify and counsel the elderly with an increased risk of hip fracture and to avoid perioperative complications in

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“…In the present study, serum vitamin D levels were comparable between the non-osteoporotic and osteoporotic groups. Similarly, few other studies demonstrated no significant difference in mean values of vitamin D between control and osteoporosis postmenopausal women ( 12 , 13 ). In contrast to our results, several studies have reported significantly lower levels of Vitamin D among osteoporotic postmenopausal women compared to the control group ( 14 , 15 ).…”

Section: Discussionmentioning

confidence: 80%

Association Between Vitamin D and Resistin in Postmenopausal Females With Altered Bone Health

Tariq

Khaliq

et al. 2021

Front. Endocrinol.

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BackgroundResistin is a relatively novel adipokine that has a role in bone remodeling and may regulate bone mineral density (BMD). Vitamin D and adipokines have a dynamic role in the body’s various metabolic processes, including bone metabolism, and may alter bone metabolism in relation to each other. This study aimed to investigate the association between vitamin D and serum resistin levels in postmenopausal non-osteoporotic and osteoporotic females.MethodsThis correlational analytical study was conducted on 161 postmenopausal females, divided into two groups, non-osteoporotic and osteoporotic, between 50–70 years. Bone mineral density (BMD) was assessed by dual-energy X-ray absorptiometry (DXA) scan. Serum resistin and vitamin D levels were analyzed by enzyme-linked immunosorbent assay (ELISA) method. Serum calcium, phosphate, and alkaline phosphatase with spectrophotometry. A correlation was checked using spearman’s rho correlation coefficient, and multivariate stepwise regression analysis was used to predict serum resistin levels.ResultsPostmenopausal females (n=161) having sufficient, insufficient and deficient levels of vitamin D were 87 (54.0%), 64 (39.8%), and 10 (6.2%), respectively. Lumbar spine BMD (p < 0.001), total hip BMD (p < 0.001), and serum resistin levels (p < 0.001) were significantly different between the two groups. There was a significant negative correlation between serum resistin and vitamin D in postmenopausal females (rho = -0.182, p = 0.021) and osteoporotic group (rho = -0.253, p = 0.019) but non-significant in non-osteoporotic group (rho = -0.077, p = 0.509). Serum vitamin D was found to be independent predictor of serum resistin levels, accounting for only 3% variance.ConclusionSerum vitamin D levels were low while serum resistin levels were high in postmenopausal osteoporotic females and vitamin D is a negative predictor of serum resistin levels.

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Vitamin D and its Relation to Bone Mineral Density in Postmenopause Women

Cited by 12 publications

References 37 publications

Prevalence of osteoporosis and osteopenia in an apparently healthy Indian population - a cross-sectional retrospective study

Prevalence of osteoporosis and osteopenia in an apparently healthy Indian population - a cross-sectional retrospective study

Hypovitaminosis D in the Greek Elderly Population Doesn't Concern Only Patients with Hip Fracture

Association Between Vitamin D and Resistin in Postmenopausal Females With Altered Bone Health

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