Vitamin D and inflammation

Cannell, John; Grant, William B.; Holick, Michael F.

doi:10.4161/19381980.2014.983401

Cited by 165 publications

(133 citation statements)

References 89 publications

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“…Cerebral ischemic damage is due to the activation of several inflammatory events, including the infiltration of circulating immune cells and activation of microglia, astrocytes, and endothelial cells [160]. In stroke individuals, the mechanism involved in vessel disease mediated by vitamin D deficit might consist of a release of atherogenic pro-inflammatory cytokines, that foster atherosclerotic vascular changes, and might induce plaque instability [161][162]. Vitamin D plays an additional role for the regulation of inflammation process, through prostaglandin inhibition, reduction of mitogen-activated protein kinase (MAPK) and reducing the expression of the nuclear factor kappa B (NF-κB) pathways [163][164][165].…”

Section: Vitamin D Deficiency and Ischemic Strokementioning

confidence: 99%

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Moretti

Morelli

Caruso

2018

Preprint

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It is widely known that vitamin D receptors have been found in neurons and glial cells and their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical grey nuclei, and substantia nigra. The vitamin D helps the regulation of neurotrophin, neural differentiation and maturation, through the control operation of growing factors synthesis (ie NGF and GDNF), the trafficking of the septo-hyppocampal pathway, and the control of the synthesis process of different neuromodulators (such as Ach, DA, and GABA).Based on these assumptions, we have written this review in order to summarize the potential role of vitamin D in neurological pathologies. The work could be titanic, and might result very fuzzy and even incoherent, if we would not have conjectured to taper our first intentions and devoted our interests towards three mainstreams: demyelinating pathologies, vascular syndromes and neurodegeneration.Due to the lack of effective therapeutic options, a part from the disease modifying strategies, the role of different risk factors should be investigated in neurology, as far as their correction may lead to the improvement of the cerebral conditions.We have explored the relationships between the gene-environmental influence and long term vitamin D deficiency, as a risk factor for the development of different types of neurological disorders, along with the role and the rationale of therapeutic trials with vitamin D implementation. Peer-reviewed version available at Int. J. Mol. Sci. 2018, 19, 2245 doi:10.3390/ijms19082245 3 SEARCH STRATEGY AND SELECTION CRITERIAWe searched MEDLINE using the search terms: "vitamin D central nervous system" , both "vitamin D" and "central nervous system"; "vitamin D immune system/response", both "vitamin D" and "immune system" or "immune response"; "vitamin D multiple sclerosis risk", both "vitamin D" and "multiple sclerosis risk"; "vitamin D multiple sclerosis relapse", both "vitamin D" and "multiple sclerosis relapse"; "vitamin D multiple sclerosis magnetic resonance imaging", both "vitamin D" and "multiple sclerosis magnetic resonance imaging"; "vitamin D multiple sclerosis disability", both "vitamin D" and "multiple sclerosis disability"; "vitamin D supplementation/therapy/treatment multiple sclerosis", both "vitamin D supplementation" or "vitamin D therapy" or "vitamin D treatment" and "multiple sclerosis"; "vascular dementia", both as -vascular-and -dementia-, "subcortical vascular dementia", both assubcortical-and -dementia-, "Alzheimer's disease", "pathogenesis neurodegeneration" "amyloid", "cholinergic afferents", "arteriolosclerosis", "cerebral flow regulation", "stroke". Publications were selected mostly form the past 20years, but did not exclude frequently referenced and highly regarded older publications. . Congress abstracts and isolated case reports were not considered. We searched the reference lists of articles identified by this search strategy and selected those we judged relevant. Review articles and book chapters are cited to provide with ...

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Section: Vitamin D Deficiency and Ischemic Strokementioning

confidence: 99%

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Moretti

Morelli

Caruso

2018

Preprint

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“…Vertinant priešuždegiminį vitamino D poveikį, vienos nuomonės nėra. Atlikti tyrimai rodo atvirkštinę priklausomybę tarp 25(OH)D ir uždegi-mo mediatorių, tačiau vis dar neaišku, ar 25(OH)D mažina uždegimą, ar dėl esamo uždegimo sumažėja 25(OH)D [5].…”

Section: įVadasunclassified

Vaikų, Sergančių Cistine Fibroze, Vitamino D Koncentracija Kraujyje

Lūžaitė¹,

Radžiūnienė²,

Dumčius³

et al. 2015

Medicinos Teorija Ir Praktika

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SANTRAUKAReikšminiai žodžiai: cistinė fibrozė, vitaminas D, vaikai, kasos funkcijos nepakankamumas. Vitamino D stoka sergantiems cistine fibroze asmenims yra labiau paplitusi, palyginti su sveikais tiriamaisiais. Viena svarbiausių to priežasčių -sutrikęs vitamino D įsisavinimas. Esant nepakankamai kasos funkcijai, vystosi riebalų, o kartu ir juose tirpių vitaminų malabsorbcija, todėl sutrinka į virškinamąjį traktą patekusio vitamino D apykaita. Kasos funkcijos nepakankamumas Šiaurės Europoje nustatomas apie 90 proc. cistine fibroze sergančių vaikų.

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“…However, at present it is controversial whether 25-OHD reduces inflammation or whether inflammation reduces 25-OHD concentrations. It is possible that both mechanisms are active and not mutually exclusive: vitamin D may decrease inflammation, while oxidative stress from inflammation may interfere with the metabolism of vitamin D and thus lower 25-OHD [56]. Randomized controlled trials of vitamin D have given inconsistent results.…”

Section: Maintenance Of Homeostasismentioning

confidence: 99%