Assessment of vitamin D status – a changing landscape

Herrmann, Markus; Farrell, Christopher-John L; Pusceddu, Irene; Fabregat-Cabello, Neus; Cavalier, Étienne

doi:10.1515/cclm-2016-0264

Cited by 180 publications

(162 citation statements)

References 201 publications

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“…This can be exploited particularly when vitamin D status has to be optimized in a short interval of time, for example when antifracture therapy has to be undertaken in subjects at high risk for fracture (e.g., after a major fragility fracture or when commencing glucocorticoid therapy). The rapidity in correcting profound vitamin D deficiency with overt or insidious osteomalacia makes calcidiol a good alternative to the mega doses of parental vitamin D 3 , recently linked to increased falls and fractures [21,22], since the non- [14,35].…”

Section: Discussionmentioning

confidence: 99%

“…The measurement of serum levels of 25-hydroxyvitamin D [25(OH)D], also referred to as calcidiol or calcifediol, still represents the preferred biomarker for the assessment of vitamin D status, reflecting the endogenous production and the exogenous exposure [1][2][3]. Calcidiol values are inversely Electronic supplementary material The online version of this article (doi:10.1007/s00198-017-4180-3) contains supplementary material, which is available to authorized users.…”

Section: Introductionmentioning

confidence: 99%

“…The most common form of vitamin D supplementation used today is cholecalciferol, also known as native or parental vitamin D 3 . The recommended daily dosage regimens are usually not able to correct rapidly vitamin D inadequacy.…”

Section: Introductionmentioning

confidence: 99%

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Correction of vitamin D status by calcidiol: pharmacokinetic profile, safety, and biochemical effects on bone and mineral metabolism of daily and weekly dosage regimens

et al. 2017

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Summary Rationale: Calcidiol can be employed to correct vitamin D deficiency. Main results: Calcidiol administered at daily and weekly regimens over a period of 3 months was able to successfully raise 25-hydroxyvitamin D levels without altering other markers related to bone and mineral metabolism. Significance: Calcidiol supplementation is effective and safe. Introduction The correction of vitamin D status is necessary to maintain an optimal mineral and skeletal homeostasis. Despite cholecalciferol (vitamin D 3 ) is the most commonly used drug for vitamin D supplementation, the more hydrophilic compound calcidiol (25-hydroxyvitamin D 3 ) can be employed at daily, weekly, and monthly regimens to reach in the short term the target levels of serum 25-hydroxyvitamin D [25(OH)D]. In the administration of different doses of calcidiol pharmacokinetic study (ADDI-D study), the efficacy and safety of daily and weekly dosages of calcidiol were tested. Methods A total of 87 Caucasian, community-dwelling, postmenopausal women, aged 55 years or older, with vitamin D inadequacy (serum 25(OH)D levels <30 ng/ml, with mean 25(OH)D below 20 ng/ml, namely 16.5 ± 7.5 ng/ml) were randomized to receive three different dosages of calcidiol: 20 μg/day, 40 μg/day, and 125 μg/week for 3 months. The attained level of serum 25(OH)D was selected as primary endpoint to assess efficacy, while other parameters of mineral metabolism, (serum calcium, parathyroid hormone, phosphate, FGF23, urinary calcium, and markers of bone turnover) were assessed as secondary endpoints to establish safety. Results In all the three groups, serum 25(OH)D values significantly and promptly rose and plateaued above the 30 ng/ml threshold remaining within safety interval after 14 days of treatment, with similar efficacy for the similar daily and weekly dose regimens. The different dosages were also equally effective in controlling secondary hyperparathyroidism. No significant changes in calcium and phosphate metabolism and in bone turnover markers were observed for any of the treatments, confirming the safety of this compound. Conclusions The results of this study demonstrate the shortand mid-term efficacy and safety on core parameters of mineral metabolism of different daily or weekly dosages of calcidiol when used to treat vitamin D inadequacy or deficiency in postmenopausal women. Further studies are needed to assess falls as primary outcome of calcidiol supplementation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Correction of vitamin D status by calcidiol: pharmacokinetic profile, safety, and biochemical effects on bone and mineral metabolism of daily and weekly dosage regimens

et al. 2017

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“…Importantly, the RIA method commonly used to assess vitamin D and related molecules may not be reliable when levels are very low, as in this patient, since RIA overestimated vitamin D and a precursor molecule, as reported elsewhere. Therefore, RIA should not be relied on solely to diagnose vitamin D deficiency, with LC-MS/MS being a better choice [3][4][5] .…”

Section: Discussionmentioning

confidence: 99%

“…Table 2), serum levels of vitamin D and related molecules were re-determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) [3][4][5] . Serum concentrations of vitamin D and its precursors and metabolites are shown in Table 2 3 were within the reference range. The plasma level of intact PTH was markedly elevated and urinary excretion of phosphate was elevated as indicated by low tubular reabsorption of phosphate.…”

Section: Introductionmentioning

confidence: 99%

A Case of Hypocalcaemia Due to Vitamin D Deficiency in ‘Hikikomori’ Syndrome

Miyakoshi

Satoh

Nomura

et al. 2017

European Journal of Case Reports in Internal Medicine

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Objective To describe hypocalcaemia due to vitamin D deficiency in ‘hikikomori’ syndrome. Materials and methods A 37-year-old man with ‘hikikomori’ syndrome for a year was admitted with hypocalcaemia (serum ionic calcium 1.17 mmol/l). Serum 1,25(OH) 2 -vitamin D 3 determined by liquid chromatography–tandem mass spectrometry was depressed at 12.1 pg/ml (29.0 pmol/l) and plasma intact PTH elevated at 324 ng/l. Administration of 1 μg/day 1α(OH)-vitamin D 3 and 1 g/day calcium lactate for 1 week normalized calcium and PTH, and raised 1,25(OH) 2 -vitamin D 3 to low normal levels. Conclusion This is the first report of hypocalcaemia due to vitamin D deficiency in a patient with ‘hikikomori’ syndrome. LEARNING POINTS A patient with psychiatric disorders can develop endocrine/metabolic abnormality. Hikikomori syndrome should be listed as a possible cause of hypocalcaemia in adults. Early diagnosis of hypocalcaemia in hikikomori syndrome prevents bone damage.

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Adaptation and co‐adaptation of skin pigmentation and vitamin D genes in native Americans

Missaggia

Reales

Cybis

et al. 2020

American J of Med Genetics Pt C

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We carried out an exhaustive review regarding human skin color variation and how much it may be related to vitamin D metabolism and other photosensitive molecules. We discuss evolutionary contexts that modulate this variability and hypotheses postulated to explain them; for example, a small amount of melanin in the skin facilitates vitamin D production, making it advantageous to have fair skin in an environment with little radiation incidence. In contrast, more melanin protects folate from degradation in an environment with a high incidence of radiation. Some Native American populations have a skin color at odds with what would be expected for the amount of radiation in the environment in which they live, a finding challenging the so‐called “vitamin D–folate hypothesis.” Since food is also a source of vitamin D, dietary habits should also be considered. Here we argue that a gene network approach provides tools to explain this phenomenon since it indicates potential alleles co‐evolving in a compensatory way. We identified alleles of the vitamin D metabolism and pigmentation pathways segregated together, but in different proportions, in agriculturalists and hunter‐gatherers. Finally, we highlight how an evolutionary approach can be useful to understand current topics of medical interest.

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Assessment of vitamin D status – a changing landscape

Abstract: Abstract:In recent years it has been shown that vitamin D deficiency is associated with an increased incidence as well as the progression of a broad range of diseases including osteoporosis, rickets, cardiovascular disease, autoimmune disease, multiple sclerosis and cancer.

Cited by 180 publications

References 201 publications

Correction of vitamin D status by calcidiol: pharmacokinetic profile, safety, and biochemical effects on bone and mineral metabolism of daily and weekly dosage regimens

Correction of vitamin D status by calcidiol: pharmacokinetic profile, safety, and biochemical effects on bone and mineral metabolism of daily and weekly dosage regimens

A Case of Hypocalcaemia Due to Vitamin D Deficiency in ‘Hikikomori’ Syndrome

Adaptation and co‐adaptation of skin pigmentation and vitamin D genes in native Americans

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