Vitamin D and hematinic deficiencies in patients with recurrent aphthous stomatitis

Al‐Amad, Suhail H.; Hasan, Hayder

doi:10.1007/s00784-019-03102-9

Cited by 19 publications

(17 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Through enrichment analysis with g:Profiler and WebGestalt, we found that ulcerative activity is related to the metabolism of vitamins (B9 and B12) and nutrients (selenium and nitrogen). Our evidence complements one of the main lines of inquiry for explaining the etiopathogenesis and severity of recurrent aphthous stomatitis with respect to nutritional deficiencies; low blood levels of iron 52 , vitamin D [53][54][55] , vitamin B9 56 and B12 57,58 have previously been reported to be associated with the presence of lesions. In our study, the levels of salivary vitamins B9 and B12 did not show significant differences.…”

Section: Discussionsupporting

confidence: 73%

Salivary proteome of aphthous stomatitis reveals the participation of vitamin metabolism, nutrients, and bacteria

Hernández-Olivos

Muñoz

Núñez

et al. 2021

Preprint

View full text Add to dashboard Cite

There are currently no preventative options for recurrent aphthous stomatitis, and the only available treatments are palliative. This is partly due to a poor understanding of its etiopathogenesis. In this case-control study, we characterized the salivary proteome of patients with recurrent aphthous stomatitis in the presence and absence of lesions. Through mass spectrometry-based proteomics and bioinformatics tools, we identified that the presence of oral ulcers is associated with several specific biological processes, including the metabolic pathways of vitamin B9, B12, nitrogen, selenium, and the bacterium Neisseria meningitidis. These changes occurred only in the presence of clinically visible lesions, and there were no relevant differences between patients in anatomical regions unaffected by ulcers. Additionally, using western blot and ELISA assays, we verified that carbonic anhydrase 1 (CA1, UniProtKB - P00915, CAH1_HUMAN) and hemoglobin subunit beta (HBB, UniProtKB - P68871, HBB_HUMAN) proteins are highly expressed during the ulcerative and remission phases of recurrent aphthous stomatitis. Our results cumulatively support saliva as an indicator of the pathophysiological changes, which occur during the clinical course of lesions. From a clinical perspective, we suggest that recurrent aphthous stomatitis is a condition triggered by temporary biological changes in people with lesions.

show abstract

Section: Discussionsupporting

confidence: 73%

Salivary proteome of aphthous stomatitis reveals the participation of vitamin metabolism, nutrients, and bacteria

Hernández-Olivos

Muñoz

Núñez

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…2,3 To elucidate the pathogenesis of RAS, researchers have suggested many influencing factors, including genetic factors, immune dysregulation, and stress, [3][4][5][6] as well as specific dietary factors. [7][8][9][10][11][12][13][14][15][16][17][18][19] It has been reported that cow's milk protein can induce RAS with an increase of antifresh cow's milk IgA, IgG, and IgE antibodies in the serum. 7,8 Other studies have suggested that some foods, such as tomatoes, oranges, lemons, and pineapple, can induce a proinflammatory cascade, leading to RAS.…”

Section: Introductionmentioning

confidence: 99%

“…[11][12][13] Additionally, deficiencies of vitamin B12, vitamin D, folic acid, ferritin, and hemoglobin may be involved in keratinocyte proliferation and immune imbalance, thereby inducing RAS. [15][16][17][18][19][20] We designed this study to explore the potential associations between RAS and several dietary factors that have been suggested to be potential influence factors in the literature or in clinical settings. 7,14 In this cross-sectional survey, we aimed to collect data regarding RAS incidence, dietary factors, self-reported trigger factors, and therapeutic methods to explore the relationships between RAS and dietary factors.…”

Section: Introductionmentioning

confidence: 99%

“… 11 – 13 Additionally, deficiencies of vitamin B12, vitamin D, folic acid, ferritin, and hemoglobin may be involved in keratinocyte proliferation and immune imbalance, thereby inducing RAS. 15 – 20 We designed this study to explore the potential associations between RAS and several dietary factors that have been suggested to be potential influence factors in the literature or in clinical settings. 7 , 14 …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between dietary factors and recurrent aphthous stomatitis in China: a cross-sectional study

Zhou

Huang

et al. 2021

J Int Med Res

View full text Add to dashboard Cite

Objective Recurrent aphthous stomatitis (RAS), a common oral mucosal disorder characterized by chronic, inflammatory, and ovoid ulcers, has a complex etiology. The purpose of the study was to investigate the specific dietary factors influencing the prevalence of RAS. Methods A total of 754 participants aged 18 to 59 years were enrolled in this descriptive cross-sectional study. An anonymous questionnaire was adopted to investigate the distribution of RAS, dietary factors, self-reported trigger factors, and therapeutic methods. Results Among all participants, the prevalence rate of RAS was 21.4%. Univariable analysis showed that fruit, dairy products, vegetables, and water, but not fried foods, fermented foods, spicy foods, and eggs, were preventive factors against RAS. After adjusting for age and sex, multivariable regression analysis suggested that fruit (adjusted odds ratio [aOR] = 0.430, 95% confidence interval [CI] = 0.218–0.847) and water (aOR = 0.294, 95% CI = 0.119–0.726) were protective factors against RAS. Conclusion This study found that the consumption of fruit and water was negatively associated with RAS. These results imply a potential adjunctive and complementary role of food in RAS treatment and some feasible means of RAS prevention.

show abstract

“…Known local predisposing factors for RAS are trauma, food hypersensitivity, dental procedures, stress, and non-smoking. [ 7 8 9 ]…”

Section: Discussionmentioning

confidence: 99%

The clinical efficacy and safety of traditional Chinese medicine in the treatment of recurrent aphthous stomatitis

Zhang

Qian

2020

Medicine

View full text Add to dashboard Cite

Background: The objective of this meta-analysis was to summarize and identify the available evidence from studies to estimate the clinical value of traditional Chinese medicine (TCM) in the treatment of recurrent aphthous stomatitis (RAS) and provides clinicians with evidence on which to base their clinical decision making. Methods: This review will include all studies comparing clinical efficacy of TCM in the treatment of RAS. The search strategy will be performed in 9 databases. We will not establish any limitations to language and publication status, published from inception to the August 2020. Two reviewers will screen, select studies, extract data, and assess quality independently. Outcome is clinical efficacy, pain relief, duration of wound healing, effect on wound healing, rate of recurrence, adverse events, and safety. The methodological quality including the risk of bias of the included studies will be evaluated. We will carry out statistical analysis using RevMan 5.3 software. Results: This study will summarize current evidence to assess the efficacy and safety of TCM in the treatment of RAS. Conclusion: The findings of this study will provide helpful evidence for the clinician, and will promote further studies, as well as studying the value of TCM. Registration number: INPLASY202080126 (DOI number: 10.37766/inplasy2020.8.0126).

show abstract

Vitamin D and hematinic deficiencies in patients with recurrent aphthous stomatitis

Cited by 19 publications

References 25 publications

Salivary proteome of aphthous stomatitis reveals the participation of vitamin metabolism, nutrients, and bacteria

Salivary proteome of aphthous stomatitis reveals the participation of vitamin metabolism, nutrients, and bacteria

Relationship between dietary factors and recurrent aphthous stomatitis in China: a cross-sectional study

The clinical efficacy and safety of traditional Chinese medicine in the treatment of recurrent aphthous stomatitis

Contact Info

Product

Resources

About