Vitamin D and Fat

Paula, Francisco José Albuquerque de; Rosen, Clifford J.

doi:10.1016/b978-0-12-381978-9.10044-7

Cited by 10 publications

(15 citation statements)

References 65 publications

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“…Conversely, only female mice with VDR haploinsufficiency showed impairment in bone acquisition. In agreement with these results, in vitro data suggest that 1,25(OH) 2 D can favor fat storage by signaling through genomic and membrane receptor pathways [69]. Additionally, it has been observed that a high calcium diet induces weight loss; it has been hypothesized that the mechanism behind the weight loss is the inhibition of 1,25(OH) 2 D synthesis [70] (Fig.…”

Section: Solar Exposure and Serum Vitamin D: Seasons And Skin Pigmentsupporting

confidence: 53%

Vitamin D safety and requirements

Paula

Rosen

2012

Archives of Biochemistry and Biophysics

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Vitamin D an ancient secosteroid is essential for mineral homeostasis, bone remodeling, immune modulation, and energy metabolism. Recently, debates have emerged about the daily vitamin D requirements for healthy and elderly adults, the safety and efficacy of long term supplementation and the role of vitamin D deficiency in several chronic disease states. Since this molecule acts as both a vitamin and a hormone, it should not be surprising that the effects of supplementation are multi-faceted and complex. Yet despite significant progress in the last decade, our understanding of vitamin D physiology and the clinical relevance of low circulating levels of this vitamin remains incomplete. The present review provides the reader with a comprehensive and up-to-date understanding of vitamin D requirements and safety. It also raises some provocative research questions.

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Section: Solar Exposure and Serum Vitamin D: Seasons And Skin Pigmentsupporting

confidence: 53%

Vitamin D safety and requirements

Paula

Rosen

2012

Archives of Biochemistry and Biophysics

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“…Помимо этого, установлено, что при избыточной массе тела увеличивается концентрация лептина, контролирующего биосинтез витамина D [8]. Лептин снижает активность фермента 1α-гидроксилазы, участвующего в образовании конечного метаболита -кальцитриола [9]. Абдоминальное ожирение и сниженный уровень 25(ОН)D выступают синергичными факторами, повышающими риск инсулинорезистентности (ИР) [10].…”

Section: ожирение и метаболизмunclassified

Study of micronutrient status of patients with obesity and diabetes mellitus type 2 based on molecular genetics analysis

Лапик¹,

Gapparova²,

Grigoryan³

et al. 2015

Obes. metabol.

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Introduction. Type 2 diabetes mellitus (type 2) is a major health problem worldwide. The progression of type 2 diabetes is contributed by usual for this patient group number of micronutrient deficiencies.Aim. To study the micronutrient status in patients with type 2 diabetes and obesity on the basis of molecular genetic studies.Materials and methods. The study involved 80 women with type 2 diabetes and obesity of I-II degree. All patients were tested for vitamin C, B6, B12, folate, a 25-hydroxyvitamin D, as well as potassium, magnesium, calcium, zinc and phosphorus in serum. DNA was isolated from blood by standard method using multicomponent lysis solution. Genotyping was performed using allele-specific amplification detection results in real time.Results. Comparative analysis of the manifestations of the polymorphic marker rs659366 UCP2 gene in patients with type 2 diabetes and obesity showed that the genotype of T/T and C/T is characterized by a low content of vitamin C in the serum than genotype of C/C. Polymorphism rs1801133 of MTHFR gene in patients with type 2 diabetes and obesity revealed that genotype C/T and T/T showed a lower content of vitamins B6, B12, folate in serum as compared with those indices in genotype C/C.Conclusion. The recommendation of vitamin-mineral complexes to patients with type 2 diabetes and obesity should be quided by molecular genetic studies, which might individually appoint the necessary micronutrients to improve the metabolic performance and reduce the risk of vascular complications in these patients.

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“…Концентрация 25(ОН)D в сыворотке находится в обратной зависимости от степени выра-женности стеатоза, фиброза и активности воспали-тельного процесса в печени [23,24]. Помимо этого установлено, что жировая ткань является самостоя-тельным эндокринным органом, и при избытке мас-сы тела увеличивается концентрация лептина [19,21], который, по мнению некоторых исследовате-лей, контролирует биосинтез витамина D. Так, леп-тин снижает активность фермента 1α-гидроксилазы, участвующего в образовании конечного активного метаболита -кальцитриола [25]. Таким образом, ожирение, очевидно, является фактором риска раз-вития дефицита витамина D.…”

Section: таблица 2 характеристика обследованных женщин в зависимостиunclassified