Vitamin D and Diagnostic Colonoscopy for Colorectal Cancer in Indonesian Population

Abstract

Objective: Colorectal cancer (CRC) is the world’s third most common type of cancer. Case studies have shown an inverse correlation between serum vitamin D levels and the incidence of human colorectal cancer. This study aims to assess vitamin D levels in patients who underwent colonoscopy for diagnostic colorectal cancer. Methods: This research is a cross-sectional study with subjects in this study were patients who came to the Digestive Surgery polyclinic and underwent a colonoscopy for diagnosis of colorectal cancer. Level of vitamin D was collected before the colonoscopy examination and categorized into three groups, vitamin D with a value of < 20 ng/mL indicate a deficiency, a level of 20 – 30 ng/mL as an insufficiency level, and a value > 30 ng/mL as a sufficient value. A colonoscopy examination was performed to obtain a diagnosis of colorectal cancer based on anatomical pathology examination. Result: Examination of vitamin D levels from 120 subjects showed the average vitamin level was 16.36 ng/mL, which indicates vitamin D deficiency levels. A total of 85 subjects (70.8%) showed vitamin D deficiency, as many as 24 (20%) showed vitamin D insufficiency levels, and only 11 study subjects (9.2%) showed sufficient vitamin D levels. The colonoscopy showed 60 subjects (50%) with colorectal cancer. The relationship between vitamin D levels and the diagnosis of CRC showed a value of p = 0.60 (p > 0.05). Conclusion: There is no significant difference between low levels of Vitamin D and the diagnosis of colorectal cancer patients.

Identification of KRAS mutation and HER2 expression in Indonesian colorectal cancer population: a cross-sectional study

“…Most of the study subjects, namely 28 subjects (48.3%), suffered from CRC stage IV, with the most metastases in the liver, namely 16/28 (57.1%), followed by 17 subjects (29.3%) suffering from stage III, 12 subjects (20.7%) in stage II, and one subject (1.7%) in stage I. This shows that patients with CRC in the Indonesian population seek medication when there are already significant clinical symptoms such as constipation, blood in the stool, and abdominal pain 20 .…”