Vitamin D and diabetes mellitus

Danescu, Liviu G.; Levy, Shiri; Levy, Joseph

doi:10.1007/s12020-008-9115-5

Cited by 160 publications

(124 citation statements)

References 127 publications

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“…It seems to suppress the antigen capacity of macrophages, inhibit the matu ration of dendritic cells, modulate the development of CD4 lymphocytes and inhibit the production of cyto kines such as interferon (IFN) and interleukin2 (IL2). These cytokines are known for activate macrophages and cytotoxic T cells, that lead to the destruction of pancreatic cells (143).…”

Section: B) Vitamin D and Diabetesmentioning

confidence: 99%

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

Maeda

Borba

Camargo

et al. 2014

Arq Bras Endocrinol Metab

224

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Objective: The objective is to present an update on the diagnosis and treatment of hypovitaminosis D, based on the most recent scientific evidence. Materials and methods: The Department of Bone and Mineral Metabolism of the Brazilian Society of Endocrinology and Metabology (SBEM) was invited to generate a document following the rules of the Brazilian Medical Association (AMB) Guidelines Program. Data search was performed using PubMed, Lilacs and SciELO and the evidence was classified in recommendation levels, according to the scientific strength and study type. Conclusion: A scientific update regarding hypovitaminosis D was presented to serve as the basis for the diagnosis and treatment of this condition in Brazil.

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Section: B) Vitamin D and Diabetesmentioning

confidence: 99%

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

Maeda

Borba

Camargo

et al. 2014

Arq Bras Endocrinol Metab

224

View full text Add to dashboard Cite

show abstract

“…Apart from this, accumulating evidence exists that vitamin D deficiency indirectly contributes to the development of arterial hypertension, diabetes mellitus, dyslipidemia, and other cardiovascular risk factors [51][52][53]. It was also shown that vitamin D exerts direct anti-atherosclerotic effects on endothelial and vascular smooth muscle cells [3,4,51].…”

Section: Indirect Effects Of Vitamin D On the Myocardiummentioning

confidence: 99%

Vitamin D deficiency and myocardial diseases

Pilz

Tomaschitz

Drechsler

et al. 2010

Molecular Nutrition Food Res

134

142

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Vitamin D deficiency is common among patients with myocardial diseases because sun-induced vitamin D production in the skin and dietary intake of vitamin D is often insufficient. Knockout mice for the vitamin D receptor develop myocardial hypertrophy and dysfunction. It has also been shown that children with rickets who suffered from severe heart failure could be successfully treated with supplementation of vitamin D plus calcium. In adults, almost all patients with heart failure exhibit reduced 25-hydroxyvitamin D levels, which are used to classify the vitamin D status. In prospective studies, vitamin D deficiency was an independent risk factor for mortality, deaths due to heart failure and sudden cardiac death. Several vitamin D effects on the electrophysiology, contractility, and structure of the heart suggest that vitamin D deficiency might be a causal factor for myocardial diseases. Data from interventional trials, however, are rare and urgently needed to elucidate whether vitamin D supplementation is useful for the treatment of myocardial diseases. In our opinion, the current knowledge of the beneficial effects of vitamin D on myocardial and overall health strongly argue for vitamin D supplementation in all vitamin D-deficient patients with or at high risk for myocardial diseases.

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“…Vitamin D status influences insulin secretion/insulin sensitivity. The effect of vitamin D on insulin secretion may be mediated by changes in intracellular calcium concentration in beta cells [21,22].Vitamin D improves insulin sensitivity by its anti-inflammatory activity. Vitamin D attenuates the expression of proinflammatory cytokines involved in insulin resistance (IR) such as interleukins, IL-1, IL-6, TNF-a, also down regulates NF-Kb (Nuclear factor) activity [23,24].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects

et al. 2012

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Vitamin D is recognized to serve a wide range of biological functions. The presence of vitamin D receptors on different tissues explains it's diversity of actions. Reduced levels of vitamin D is associated with insulin resistance and increased diabetes risk. The study included 50 normal healthy individuals and 49 type 2 diabetes subjects. Fasting blood glucose, total cholesterol, triglycerides, HDLc, fasting insulin, parathyroid hormone, calcium, albumin and Homeostasis model for assessment of insulin resistance (HOMAIR) were measured in all the study participants. Type 2 diabetes subjects were divided into group 1 with 25 hydroxy vitamin D (25(OH)D) B20 ng/ml and group 2 with 25(OH)D [20 ng/ml. By the results of this study, the mean 25(OH)D level was low (20.09 ng/ml) in type 2 diabetes compared to controls (23.89 ng/ml) and the p value was 0.02. The estimated insulin resistance by HOMAIR was more in group 1 than in group 2 of diabetes with p value of 0.037. The Pearson's correlation-coefficient was negative for 25(OH)D and insulin in type 2 diabetes (r = -0.294), 25(OH)D was negatively correlated with HOMAIR in total subjects. Type 2 diabetes subjects had reduced levels of vitamin D than normal individuals. The insulin resistance was more in vitamin D deficiency state. Hence vitamin D has a role in glucose metabolism, deficiency can result in insulin resistance and diabetes.

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Vitamin D and diabetes mellitus

Cited by 160 publications

References 127 publications

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

Recomendações da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) para o diagnóstico e tratamento da hipovitaminose D

Vitamin D deficiency and myocardial diseases

Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects

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