Vitamin D and Diabetes

Martín, T. Mozo; Campbell, R. Keith

doi:10.2337/diaspect.24.2.113

Cited by 52 publications

(69 citation statements)

References 52 publications

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“…In our study, the prevalence of severe vitamin D deficiency was much higher among the older age-group (27%), however, serum 25(OH)D was not statistically significant positively correlated with age r= 0.079 (p=0.1), in consistent with most studies whereas other studies reported the higher prevalence of vitamin D deficiency among the young people. [7], [35][36][37][38][39][40][41][42] The positive correlation of 25(OH)D to age is in disagreement with a study carried out in the US, where severe vitamin D deficiency was found to be more common among the young, and less common among the elderly. 43 Recent studies have shown vitamin D deficiency among healthy young Saudi women of age 25 to 35 years was 30% and 55% in women of 50 years or more, indicating that it is common in young and postmenopausal women.…”

Section: Discussionmentioning

confidence: 85%

Severe Vitamin D Deficiency in Saudi Patients with Type 2 Diabetes Mellitus

Aljabri

Bokhari

2019

JOM

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Introduction It has been demonstrated that vitamin D deficiency is associated with type 2 diabetes mellitus (T2DM). We conducted a cross sectional study to investigate the prevalence severe vitamin D deficiency in patients with T2DM. Method A cross-sectional single centre study was conducted in 4053 patients with T2DM. Patients with T2DM attended the Diabetes Centre at King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia between January 2018 and December 2018 were recruited. Results There were 4053 patients with T2DM, 1145 male and 2908 female (28 % vs.72% respectively). The mean age was 53.9 ±16.5 years. The mean and median 25-OHD concentrations were 57.8±30.5 and 51.9 respectively. Severe vitamin D deficiency (25-OHD<25 nmol/l) was found in 1916 (9.5%). Moreover, severe vitamin D deficiency was not statistically significant more prevalent among females than males with male to female ratio 1:2.3 (70% vs. 30% respectively, p=0.6). In addition, severe vitamin D deficient patients were statistically significant younger than non-vitamin D deficient (48.0±16.7 vs. 54.6±16.3 respectively, p<0.0001). Severe vitamin D deficient patients have statistically significant higher HbA1c than non-vitamin D deficient (8.3 ±2.3 vs. 7.6±1.9 respectively, p<0.0001). The mean 25-OHD was upward as age advanced with highest frequency of vitamin D deficiency was found in the age group ≥60 years (27%) with males statistically significant most frequent than females in the age group ≥60 years (39 s, 22 respectively, p=0.003). Regression analysis of odd ratio of risk factors for patients with severe vitamin D deficiency showed that age and HbA1c were statistically significant associated with vitamin D deficiency. Conclusions The prevalence of severe vitamin D deficiency in patients with T2DM is low and that more females with T2DM are affected with vitamin D deficiency than males.

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Section: Discussionmentioning

confidence: 85%

Severe Vitamin D Deficiency in Saudi Patients with Type 2 Diabetes Mellitus

Aljabri

Bokhari

2019

JOM

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“…Furthermore, there is evidence that low vitamin D status has been associated with diabetes in the general population [18], as well as gestational diabetes mellitus [19] and preeclampsia [20] among pregnant women. Vitamin D influences calcium homeostasis [14] and is useful for the growth of the skeleton and healthy bones [3].…”

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confidence: 99%

The Use of Dietary Supplements Among African and Caribbean Women Living in the UK: A Cross-Sectional Study

2020

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Previous studies have shown that the use of dietary supplements is associated with the prevention of birth defects, negative pregnancy outcomes and cardiovascular diseases. However, there might be some ethnic disparities in supplement usage suggesting that women who could benefit from it are not frequent users. This study aimed to characterise the use of dietary supplement among Black African and Black Caribbean women living in the United Kingdom (UK). Furthermore, it evaluated possible associations between the use of dietary supplements and health and diet awareness. A total of 262 women self-ascribed as Black African and Black Caribbean living in the UK completed a comprehensive questionnaire on socio-demographic factors, diet, use of supplements and cultural factors. The main outcome variable was the regular use of any type of dietary supplement. Use of vitamin D and/or calcium was also explored. A stepwise logistic regression analysis was applied to identify predictors of regular use of dietary supplements. A total of 33.2% of women reported regular use of any dietary supplements and 16.8% reported use of vitamin D and/or calcium. There were no significant ethnic differences in the use of dietary supplements. Reporting use of the back of food packaging label (odds ratio (OR) 2.21; 95% CI 1.07-4.55); a self-rated healthy diet (OR 2.86; 95% CI 1.19-6.91) and having cardiovascular disease (CVD), hypertension and/or high cholesterol (OR 3.81; 95% CI 1.53-9.49) increased the likelihood of using any dietary supplement. However, having poorer awareness decreased the likelihood (OR 0.94; 95% CI 0.88-0.99) of using any dietary supplement. For the use of vitamin D and/or calcium supplements, the main predictor was having CVD, hypertension and/or high cholesterol (OR 4.43; 95% CI 1.90-10.35). The prevalence of dietary supplement use was low among African and Caribbean women. Thus, awareness of potential benefits of some dietary supplements (e.g., vitamin D) among the Black population should be promoted.

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“…Vitamin D has been recently catapulted to limelight with research studies linking vitamin D apart from bone health to an exhaustive list of diseases ranging from cancer, heart disease, multiple sclerosis, parkinsons disease, obesity, aging and falls to diabetes 3. The metabolic product of vitamin D is a potent, pleiotropic, repair and maintenance, secosteroid hormone that targets more than 200 human genes in a wide variety of tissues, meaning that it has as many mechanisms of action as genes it targets 4…”

Section: Discussionmentioning

confidence: 99%

Lamellar ichthyosis with genu valgum: unfolding the link

2012

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SummaryWe describe a case of lamellar ichthyosis with bilateral genu valgum. The association of genu valgum with congenital ichthyosis is rare. Our patient, a 22-year-old girl, had lamellar ichthyosis and was born with a collodion membrane. She developed progressive valgus deformity of the knees of 5 years duration associated with difficulty in walking. On evaluation, she had generalised scaly skin lesions along with bilateral genu valgum and biochemical evidence of vitamin D deficiency. Skin serves as an important site for vitamin D synthesis and thus skeletal deformities secondary to vitamin D deficiency may occur in cases of congenital ichthyosis, causing a diagnostic dilemma due to the unusual association. This case serves as a reminder that clinicians need to be aware of such an association in order to prevent, appropriately diagnose and adequately treat the rare case of congenital ichthyosis with rickets and osteomalacia. BACKGROUND

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Vitamin D and Diabetes

Cited by 52 publications

References 52 publications

Severe Vitamin D Deficiency in Saudi Patients with Type 2 Diabetes Mellitus

Severe Vitamin D Deficiency in Saudi Patients with Type 2 Diabetes Mellitus

The Use of Dietary Supplements Among African and Caribbean Women Living in the UK: A Cross-Sectional Study

Lamellar ichthyosis with genu valgum: unfolding the link

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